Paraoxonase 3 expression is spatially down-regulated in the human placenta in labour

The placenta is an essential organ formed during pregnancy that mainly transfers nutrients from the mother to the fetus. Nutrients taken up by the placenta are required for its own growth and development and to optimize fetal growth. Hence, placental function is an important determinant of pregnancy outcome. Among various nutrients, fatty acids, especially long-chain polyunsaturated fatty acids (LCPUFAs), including omega 3 and omega 6 fatty acids, are essential for placental development from the time of implantation. Studies have associated these LCPUFAs with placental development through their roles in regulating oxidative stress, angiogenesis, and inflammation, which may in turn influence their transfer to the fetus. The placenta has a heterogeneous morphology with variable regional vasculature, oxidative stress, and LCPUFA levels in healthy pregnancies depending upon the location within the placenta. However, these regional structural and functional parameters are found to be disturbed in pathological conditions, such as preeclampsia (PE), thereby affecting pregnancy outcome. Hence, the alterations in LCPUFA metabolism and transport in different regions of the PE placenta as compared with normal placenta could potentially be contributing to the pathological features of PE. The regional variations in development and function of the placenta and its possible association with placental LCPUFA metabolism and transport in normal and PE pregnancies are discussed in this review. WIREs Dev Biol 2016, 5:582-597. doi: 10.1002/wdev.238 For further resources related to this article, please visit the WIREs website.

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Altered development and function of the placental regions in preeclampsia and its association with long‐chain polyunsaturated fatty acids

Rani

Wadhwani

Chavan‐Gautam

et al. 2016

WIREs Developmental Biology

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Paraoxonase 3 expression is spatially down-regulated in the human placenta in labour

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Altered development and function of the placental regions in preeclampsia and its association with long‐chain polyunsaturated fatty acids

Altered development and function of the placental regions in preeclampsia and its association with long‐chain polyunsaturated fatty acids

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