Paraoxonase-2 and paraoxonase-3: comparison of mRNA expressions in the placentae of unexplained intrauterine growth restricted and noncomplicated pregnancies

Dikbaş, Levent; Yapça, Ömer Erkan; Dikbaş, Neslihan; Gündoğdu, Cemal

doi:10.1080/14767058.2016.1209480

Cited by 6 publications

(5 citation statements)

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“…NSAIDs, like diclofenac sodium and tenoxicam, have been tested in vitro , causing a significant decline in lactonase activity (Solmaz Avcıkurt and Korkut 2018 ). On the other hand, antenatal steroid therapy did not affect PON2 mRNA expression in placentae of unexplained intrauterine growth restricted pregnancies as compared to the non-treated group (Dikbas et al 2017 ). It is also hypothesized that increased cholesterol content may be the cause of decreased PON2 expression (Rosenblat et al 2004 ).…”

Section: Regulation Of Pon2 Expressionmentioning

confidence: 96%

Insights into the role of paraoxonase 2 in human pathophysiology

Parween

Gupta

2022

J Biosci

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Paraoxonase 2 (PON2) is a ubiquitously expressed intracellular enzyme that is known to have a protective role from oxidative stress. Clinical studies have also demonstrated the significance of PON2 in the manifestation of cardiovascular and several other diseases, and hence, it is considered an important biomarker. Recent findings of its expression in brain tissue suggest its potential protective effect on oxidative stress and neuroinflammation. Polymorphisms of PON2 in humans are a risk factor in many pathological conditions, suggesting a possible mechanism of its anti-oxidative property probably through lactonase activity. However, exogenous factors may also modulate the expression and activity of PON2. Hence, this review aims to report the mechanism by which PON2 expression is regulated and its role in oxidative stress disorders such as neurodegeneration and tumor formation. The role of PON2 owing to its lactonase activity in bacterial infectious diseases and association of PON2 polymorphism with pathological conditions are also highlighted.

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Section: Regulation Of Pon2 Expressionmentioning

confidence: 96%

Insights into the role of paraoxonase 2 in human pathophysiology

Parween

Gupta

2022

J Biosci

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“…Intra-uterine growth restriction, (affecting 10–15 % of pregnant women) is a principal cause of peri-natal morbidity and mortality [128,129]. It has been reported that higher levels of ROS and inflammatory biomarkers have a central play in development and pathology of intra-uterine growth restriction [130,131].…”

Section: Role Of Se In Pregnancymentioning

confidence: 99%

Selenium, Selenoproteins, and Female Reproduction: A Review

et al. 2018

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Selenium (Se) is an essential micronutrient that has several important functions in animal and human health. The biological functions of Se are carried out by selenoproteins (encoded by twenty-five genes in human and twenty-four in mice), which are reportedly present in all three domains of life. As a component of selenoproteins, Se has structural and enzymatic functions; in the latter context it is best recognized for its catalytic and antioxidant activities. In this review, we highlight the biological functions of Se and selenoproteins followed by an elaborated review of the relationship between Se and female reproductive function. Data pertaining to Se status and female fertility and reproduction are sparse, with most such studies focusing on the role of Se in pregnancy. Only recently has some light been shed on its potential role in ovarian physiology. The exact underlying molecular and biochemical mechanisms through which Se or selenoproteins modulate female reproduction are largely unknown; their role in human pregnancy and related complications is not yet sufficiently understood. Properly powered, randomized, controlled trials (intervention vs. control) in populations of relatively low Se status will be essential to clarify their role. In the meantime, studies elucidating the potential effect of Se supplementation and selenoproteins (i.e., GPX1, SELENOP, and SELENOS) in ovarian function and overall female reproductive efficiency would be of great value.

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“…Intrauterine growth restriction (IUGR) is still an important pregnancy complication bringing on perinatal mortality and morbidity and affects 10-15% of pregnant women [1]. IUGR is mostly described as the estimated fetal weight (EFW), measured by ultrasonoghraphically, being under 10th percentile for gestational age using populationspecific fetal growth curves [2].…”

Section: Introductionmentioning

confidence: 99%

“…Prematurity is the first most frequent reason of the perinatal mortality and IUGR is the second. Stillbirth is a very annoying condition for the obstetricians and stillbirth rates of IUGR babies are 5-10 fold more frequent with an incidence of 23-65% than normal babies [1]. A quarter of all stillbirths are complicated with IUGR [1].…”

Section: Introductionmentioning

confidence: 99%

“…Stillbirth is a very annoying condition for the obstetricians and stillbirth rates of IUGR babies are 5-10 fold more frequent with an incidence of 23-65% than normal babies [1]. A quarter of all stillbirths are complicated with IUGR [1]. Various factors could affect the risk of fetal death with growth restriction such as gestational age, the amniotic fluid level, umbilical artery and middle cerebral artery doppler ultrasound evaluation and the etiology of IUGR [3].…”

Section: Introductionmentioning

confidence: 99%

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Is there any relation between intrauterine growth restriction and platelet distribution width (PDW), platelet crit (PCT), mean platelet volume (MPV)? A prospective study

Sayan

Yeral

2018

Ortadogu Tıp Derg

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Aim: Intrauterine growth restriction (IUGR) is still an important pregnancy complication bringing on perinatal mortality and morbidity. Placental vascular dysfunction and subsequent obliteration of placental blood vessels are mostly accepted etiopathological factors of intrauterine growth restriction similar with preeclampsia. We aimed to investigate the possible difference between pregnant women suffering from intrauterine growth restriction and healty pregnant women for parameters of platelet count, platelet crit, platelet distribution crit and mean platelet volume. Material and Method: This case-control study was conducted with 179 pregnant women. The study population was consisted of 94 pregnant women complicated with idiopathic IUGR (study group) and 85 healty pregnant women (control group). IUGR group was divided in two subgroups according to umbilical artery doppler velocimetry measurements. Complete blood count parameters including hemoglobin, platelet count, platelet distribution width (PDW), platelet crit (PCT), mean platelet volume (MPV) and white blood cell count (WBC) were measured. Results: There was no significant difference between the groups for parameters of hemoglobin, PC and PCT. The mean amniotic fluid index of IUGR group was significantly lower than the control group (p=0.000). The mean WBC, MPV and PDW levels of IUGR group were significantly higher than the control group (p=0.013, p=0.047 and 0.035, respectively). The mean MPV level of IUGR group 1(umbilical artery S/D˃3) was significantly higher than that of IUGR group 2 (umbilical artery S/D<3) (p=0.045). Conclusions: In the present study, we observed a significant difference between IUGR and healty pregnant women for platelet parameters of MPV and PDW. Beside this, we also observed higher MPV values in IUGR patients with increased umblical artery resistance compared to that in IUGR patients with normal umblical artery blood flow. Further studies are needed to discuss our results.

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Paraoxonase-2 and paraoxonase-3: comparison of mRNA expressions in the placentae of unexplained intrauterine growth restricted and noncomplicated pregnancies

Abstract: These results suggest that PON2, PON3 mRNA levels were not changed significantly in placentae of IUGR when compared to normal pregnant women.

Cited by 6 publications

References 20 publications

Insights into the role of paraoxonase 2 in human pathophysiology

Insights into the role of paraoxonase 2 in human pathophysiology

Selenium, Selenoproteins, and Female Reproduction: A Review

Is there any relation between intrauterine growth restriction and platelet distribution width (PDW), platelet crit (PCT), mean platelet volume (MPV)? A prospective study

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