Paraoxonase 1 (PON1) gene polymorphism and haplotype analysis in type 2 diabetes mellitus: a case–control study in the south Iranian population

Moasser, Elham; Azarpira, Negar; dalini, Ali Ghorbani; Shirazi, Babak

doi:10.1007/s13410-016-0544-z

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…Antioxidants form part of protective mechanisms that exist in human cells to scavenge and neutralize these oxidants. Oxidants such as the reactive oxygen species (ROS) and reactive nitrogen species (RNS) are involved in several diseases [1, 2]. Antioxidant defenses are defective in these diseases and therefore it is possible to limit oxidative damage and ameliorate disease progression with antioxidant supplementation [3].…”

Section: Introductionmentioning

confidence: 99%

African Herbal Remedies with Antioxidant Activity: A Potential Resource Base for Wound Treatment

Gulumian

Yahaya

Steenkamp

2018

Evidence-Based Complementary and Alternative Medicine

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The use of traditional herbal remedies as alternative medicine plays an important role in Africa since it forms part of primary health care for treatment of various medical conditions, including wounds. Although physiological levels of free radicals are essential to the healing process, they are known to partly contribute to wound chronicity when in excess. Consequently, antioxidant therapy has been shown to facilitate healing of such wounds. Also, a growing body of evidence suggests that, at least, part of the therapeutic value of herbals may be explained by their antioxidant activity. This paper reviews African herbal remedies with antioxidant activity with the aim of indicating potential resources for wound treatment. Firstly, herbals with identified antioxidant compounds and, secondly, herbals with proven antioxidant activity, but where the compound(s) responsible for the activity has not yet been identified, are listed. In the latter case it has been attempted to ascribe the activity to a compound known to be present in the plant family and/or species, where related activity has previously been documented for another genus of the species. Also, the tests employed to assess antioxidant activity and the potential caveats thereof during assessment are briefly commented on.

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Section: Introductionmentioning

confidence: 99%

African Herbal Remedies with Antioxidant Activity: A Potential Resource Base for Wound Treatment

Gulumian

Yahaya

Steenkamp

2018

Evidence-Based Complementary and Alternative Medicine

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Paraoxonase 1 (PON1) L55M and Q192R Polymorphisms are Associated with Type 2 Diabetes Mellitus in Southern Thai Subjects

2020

J Med Assoc Thai

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Background: Paraoxonase 1 (PON1) plays a critical role in the prevention of cardiovascular disease, diabetes mellitus, and other chronic diseases. Objective: The aim of the present study was to investigate the association of PON1 L55M and Q192R polymorphisms with type 2 diabetes mellitus (T2DM), and pre-diabetes. Materials and Methods: The present study included 512 subjects (223 T2DM patients, 150 pre-diabetes, and 139 healthy controls) from Southern Thailand. The PON1 L55M and Q192R polymorphisms were analyzed by polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) technique. Results: PON1 Q192R polymorphism showed a statistical difference in genotype frequencies between T2DM patients and healthy controls (p<0.0001). Multiple logistic regression analyses after adjusting for age, gender, and BMI showed that LM and RR genotypes increased the risk for T2DM compared with LL and QQ+QR genotypes (OR 1.96; 95% CI 1.02 to 3.76, p=0.042, and OR 1.85; 95% CI 1.11 to 3.10, p=0.019, respectively). Whereas, QR, genotype was associated with decreased risk for T2DM (OR 0.240; 95% CI 0.13 to 0.45, p<0.0001), and pre-diabetes (OR 0.549; 95% CI 0.30 to 0.99, p=0.048) compared with QQ genotype. Conclusion: PON1 LM and RR genotypes may be genetic risk factors for developing T2DM but QR genotype may prevent T2DM, and pre-diabetes in Southern Thai population. Keywords: PON1, Polymorphisms, Type 2 diabetes, Pre-diabetes

show abstract

Paraoxonase 1 (PON1) gene polymorphism and haplotype analysis in type 2 diabetes mellitus: a case–control study in the south Iranian population

Cited by 2 publications

References 35 publications

African Herbal Remedies with Antioxidant Activity: A Potential Resource Base for Wound Treatment

African Herbal Remedies with Antioxidant Activity: A Potential Resource Base for Wound Treatment

Paraoxonase 1 (PON1) L55M and Q192R Polymorphisms are Associated with Type 2 Diabetes Mellitus in Southern Thai Subjects

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