Paraoxonase-1 concentrations in end-stage renal disease patients increase after hemodialysis: Correlation with low molecular AGE adduct clearance

Gugliucci, Alejandro; Mehlhaff, Krista M.; Kinugasa, Eriko; Ogata, Hiroaki; Hermo, Ricardo; Schulze, John; Kimura, Satoshi

doi:10.1016/j.cca.2006.09.028

Cited by 67 publications

(69 citation statements)

References 34 publications

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“…correlation between PON-1 activity and serum concentrations of urea and creatinine. According to Gugliucci and colleagues, these results suggest another type of mechanism related to uremic toxins retention that possibly causes the Journal of Biophysical Chemistry impairment of HDL's PON-1 antioxidant function [3]. Rajković et al [20] also found a reduced PON-1 activity in patients with ESRD when replicating the in vitro experiments performed by Gugliucci et al [3].…”

Section: Discussionsupporting

confidence: 63%

“…They found a significant increase in PON-1 activity at pre-and post-HD, by conducting an experiment with 20 ESRD patients. Gugliucci et al [3] in a similar study, also found a significant PON-1 increased activity at post-HD. However, they found a negative F. S. Marques et al Table 4. 14 C-PL and PON-1 linear correlation coefficient from ESRD patients age groups at pre and post hemodialysis.…”

Section: Discussionmentioning

confidence: 62%

“…These individuals show various metabolic abnormalities that contribute to the development of advanced atherosclerosis [3]. Besides traditional atherogenic risk factors, few biomarkers have been postulated to be relevant cardiovascular risk markers in ESRD, including aspects of malnutrition, anemia, hypoalbuminemia, elevated fibrinogen levels, oxidative stress and inflammation [4].…”

Section: Introductionmentioning

confidence: 99%

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Low-Flow Polysulfone Hemodialysis Alters Lipoprotein Parameters, Paraoxonase Activity and <i>in Vitro</i> Incorporation of Phospholipids

Marques¹,

Silva²,

Mattoso³

et al. 2017

JBPC

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End stage-renal-disease (ESRD) is associated with dyslipidemia and premature atherosclerosis. The study evaluates the effect of hemodialysis (HD) on HDL-remodeling between pre-and post-HD. Was conducted a cross-sectional study with 50 ESRD male patients, undergoing HD at Ana Neri Hospital, Salvador, Brazil. All individuals were on HD for at least 3 months, into a three sessions protocol for 3 -4 hours per week, with a polysulfone low-flow basicdialyzing-membrane and unfractionated-heparin. HDL Phospholipid-incorporation was measured by 14 C-PL-scintillation-counting, expressed as % 14 C-PL/mL/hour. Paraoxonase (PON-1) activity was measured by spectrophotometry using paraoxon as substrate. Cardiovascular risk ratios and atherogenic index of plasma were calculated. Total cholesterol, HDL-C and non-HDL-C increased at post-HD on all age groups, but without triglycerides (TG) changes. TG/HDL-C decreased in 30 -39 and 40 -49 year (y) at post-HD (p < 0.05). LDL-C/apoB increased in >60 y, after HD (p < 0.05). HDL-C/apo-AI increased in 40 -49 y (p < 0. C-PL-incorporation was reduced in >60 y (p < 0.05), when compared to pre-and post-HD. ESRD patients undergoing HD shows important changes on lipid-profile, PON-1-activity, cardiac risk ratios and HDL-remodeling. These results demonstrate the influence of HD with a polysulfone low-flow basic-dialyzing-membrane and unfractionated-heparin on lipoprotein metabolism.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

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Low-Flow Polysulfone Hemodialysis Alters Lipoprotein Parameters, Paraoxonase Activity and <i>in Vitro</i> Incorporation of Phospholipids

Marques¹,

Silva²,

Mattoso³

et al. 2017

JBPC

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“…14 There is limited evidence concerning the comparison of oxLDL concentration in patients treated with different modes of dialysis, 15 although there are few studies about the comparison of antibodies against oxLDL in dialysis subgroups of patients. Also to our knowledge, the effect of hemodialysis (HD) on distribution of HDL subclasses in serum has been studied recently [16][17][18][19][20] but no data about the effect of peritoneal dialysis (PD) have been reported. This study attempts to look into the comparison of oxLDL levels, lipids, and lipoproteins in patients on HD and PD and in normal controls (NC).…”

Section: Introductionmentioning

confidence: 99%

Lipid Abnormalities and Oxidized LDL in Chronic Kidney Disease Patients on Hemodialysis and Peritoneal Dialysis

et al. 2011

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Dyslipoproteinemia and oxidative modification of low-density lipoprotein (oxLDL) contribute to the development of oxidative stress and atherosclerosis in chronic kidney disease (CKD). On the contrary, high-density lipoprotein cholesterol (HDL-C), especially HDL3-C subtype, has protective effect against oxidative damage. There is limited evidence referring HDL-C subclass levels in patients on dialysis. This study was designed to compare lipid abnormalities and oxLDL levels in hemodialysis (HD) and peritoneal dialysis (PD) patients. Serum lipids, HDL subclasses, and oxLDL were measured in 55 patients with CKD-stage 5 (31 patients on HD and 24 patients on PD) and in 21 normal controls (NC). The results showed that in dialysis patients, triglycerides were higher than in controls (p < 0.0001) and HDL-C was significantly lower (p < 0.0001). The HDL2-C subclass concentration did not differ significantly between patients and controls, while HDL3-C was lower in patients (11 ± 0.5 mg/dL) than in NC (23 ± 1, p < 0.0001). oxLDL levels were markedly increased in patients (1.92 ± 0.29 mg/L) compared to NC (0.22 ± 0.05, p < 0.0001). Patients on PD had higher levels of cholesterol (p < 0.001) and apolipoprotein B (p < 0.05) than patients on HD. However, HDL-C, HDL-C subclasses, and oxLDL concentrations did not differ significantly between PD and HD patients. It is concluded that patients with CKD have a nearly 10-fold elevation of oxLDL compared with NC. Patients on PD have differences in the lipid profile compared with patients on HD; however, both modalities seem to possess similar potential to atherosclerosis development.

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“…Increase of left ventricular mass in hypertensive patients has predictive value and better predictor of cardiac complication. 30,31 OS is related with cardiovascular damage in earlier and late stages of CRF in both adults and pediatric population. 27,32 In our study, no statistical significance was observed between echocardiographic indexes and plasma GSHpx; however, negative correlation between MDA and EF (r = −0.380, p < 0.001) or between SOD and systolic-diastolic blood pressure suggests particular role of OS on left ventricle hypertrophy.…”

Section: Discussionmentioning

confidence: 99%

Parameters of oxidative stress and echocardiographic indexes in patients on dialysis therapy

Kayabaşı

Şit²,

Atay

et al. 2010

Renal Failure

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Aim: Quantity of oxidative stress (OS) is enhanced in every stage of chronic renal failure (CRF). OS and its effects on echocardiographic indexes in patients on hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) were evaluated. Materials and methods: Thirty-nine patients on CAPD, 32 patients on HD, and 30 healthy individuals with similar demographic features were included. Patients with diabetes mellitus and chronic inflammatory diseases were excluded. Blood samples were collected to examine hematological and biochemical parameters and levels of malonyldialdehyde (MDA), glutathione peroxidase (GSH-px), and superoxide dismutase (SOD) after a 12-hour fasting period in the middle of dialysis week. OS parameters were compared with ejection fraction (EF), interventricular septum diameter (IVSd), left ventricular posterior wall diameter (LVPWd), and left atrium diameter (LAd) determined in M-mod echocardiographic examination. Results: No significant difference was observed between MDA and GSH-px levels of patients and control group; however, SOD levels of patients group were significantly lower (p < 0.0001). SOD levels of patients on HD were lower than that of patients on CAPD (p = 0.039). No correlation was determined between antioxidants and cardiac indexes. Conclusion: SOD levels decreased significantly especially in patients on HD, and it was observed that lower levels of SOD would lead to OS in patients on HD and CAPD when compared to healthy individuals; MDA levels were independently influenced from EF.

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Paraoxonase-1 concentrations in end-stage renal disease patients increase after hemodialysis: Correlation with low molecular AGE adduct clearance

Cited by 67 publications

References 34 publications

Low-Flow Polysulfone Hemodialysis Alters Lipoprotein Parameters, Paraoxonase Activity and <i>in Vitro</i> Incorporation of Phospholipids

Low-Flow Polysulfone Hemodialysis Alters Lipoprotein Parameters, Paraoxonase Activity and <i>in Vitro</i> Incorporation of Phospholipids

Lipid Abnormalities and Oxidized LDL in Chronic Kidney Disease Patients on Hemodialysis and Peritoneal Dialysis

Parameters of oxidative stress and echocardiographic indexes in patients on dialysis therapy

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Paraoxonase-1 concentrations in end-stage renal disease patients increase after hemodialysis: Correlation with low molecular AGE adduct clearance

Cited by 67 publications

References 34 publications

Low-Flow Polysulfone Hemodialysis Alters Lipoprotein Parameters, Paraoxonase Activity and &lt;i&gt;in Vitro&lt;/i&gt; Incorporation of Phospholipids

Low-Flow Polysulfone Hemodialysis Alters Lipoprotein Parameters, Paraoxonase Activity and &lt;i&gt;in Vitro&lt;/i&gt; Incorporation of Phospholipids

Lipid Abnormalities and Oxidized LDL in Chronic Kidney Disease Patients on Hemodialysis and Peritoneal Dialysis

Parameters of oxidative stress and echocardiographic indexes in patients on dialysis therapy

Contact Info

Product

Resources

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Low-Flow Polysulfone Hemodialysis Alters Lipoprotein Parameters, Paraoxonase Activity and <i>in Vitro</i> Incorporation of Phospholipids

Low-Flow Polysulfone Hemodialysis Alters Lipoprotein Parameters, Paraoxonase Activity and <i>in Vitro</i> Incorporation of Phospholipids