Abstract:ÖzetÇok sayıda iç organ kanseri deride pruritus (kaşıntı) ve eritrodermi ile giden tablolara yol açabilir. Bu tablolar iç organ kanserinin erken döneminde görülebilir veya onun aylar öncesinden ilk habercileri olabilir. Diğer yandan kaşıntı ve eritrodermi paraneoplastik hastalıklar için özgül semptomlar değildir; çok sayıda farklı nedenlerle ortaya çıkabilirler. Bu derlemede iç organ kanserlerine bağlı kaşıntı (paraneoplastik kaşıntı) ve eritrodermi (paraneoplastik eritrodermi)'nin epidemiyolojik ve klinik öze… Show more
“…There are many historical publications with evidence-based articles on this topic which are available in English literature. [4][5][6][7][8]10,[14][15][16][17][18][19][20][21][22][23][24][25] Prof.Dr. Hulusi Behçet deserves to have the disease named after him, because he was the first modern author to group the various ophthalmic, dermatological, and orogenital lesions together as a syndrome.…”
mentioning
confidence: 99%
“…[3][4][5][6][7][8] This patient, who had been examined because of eye disturbances, recurrent oral and genital ulcers both in Istanbul and Vienna for 40 years, was given several diagnoses. Some doctors thought of tuberculosis or syphilis while some other doctors said a microorganism which was not present in Europe might have caused the disease.…”
“…There are many historical publications with evidence-based articles on this topic which are available in English literature. [4][5][6][7][8]10,[14][15][16][17][18][19][20][21][22][23][24][25] Prof.Dr. Hulusi Behçet deserves to have the disease named after him, because he was the first modern author to group the various ophthalmic, dermatological, and orogenital lesions together as a syndrome.…”
mentioning
confidence: 99%
“…[3][4][5][6][7][8] This patient, who had been examined because of eye disturbances, recurrent oral and genital ulcers both in Istanbul and Vienna for 40 years, was given several diagnoses. Some doctors thought of tuberculosis or syphilis while some other doctors said a microorganism which was not present in Europe might have caused the disease.…”
Chronic pruritus is a major and distressing symptom of many diseases of dermatological, neurological, psychogenic or systemic origin. This chronic itch could be a presenting sign of malignancy; therefore, paraneoplastic pruritus has also been associated with neuroendocrine tumors (NETs). This article focuses on a patient presenting with chronic pruritus for the past 12 months and who received numerous treatment schemes with very poor clinical improvement, that presented in the hospital for worsening of the chronic pruritus associated with skin rash and significant weight loss (approximately 6 kg over a 2-month period). The laboratory tests showed iron deficiency anemia, eosinophilia and negative tumor markers. In order to investigate the hypoanabolic and anemic syndromes, upper gastrointestinal endoscopy and colonoscopy, which showed no lesions or tumors, were employed. Skin biopsy was performed and antihistaminic and local steroid treatment was initiated. The patient's status worsened within a week and the patient was started on systemic steroid treatment with poor results. Computer tomography was performed to identify any tumor(s) located either in the pelvis or abdomen. A lesion was found in the terminal ileum, identified as a hypervascularized associating bulky lymphadenopathy. The patient was transferred to the surgical ward where right hemicolectomy with manual ileotransverse anastomosis L-L was performed. The histopathological result confirmed NET G2. The patient clinically improved, the skin lesions resolved and the itchiness disappeared. The general status improved significantly. NET G2 diagnosing was possible due to the atypic paraneoplastic sign: chronic pruritus. This case study highlights the association between itch and malignancy and presents an atypical way of NET presentation when all tumor markers remain negative.
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