Paraneoplastic Pemphigus Presenting as a Lichen Planus Pemphigoides—like Eruption

Stevens, Seth R.; Griffiths, Christopher E.M.; Anhalt, Grant J.; Cooper, Kevin D.

doi:10.1001/archderm.1993.01680280054010

Cited by 75 publications

(17 citation statements)

References 24 publications

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“…7 They comment that malignancy should be considered in LPP, although their patient had the features of LP and pemphigus rather than pemphigoid. 7 They comment that malignancy should be considered in LPP, although their patient had the features of LP and pemphigus rather than pemphigoid.…”

Section: Discussionmentioning

confidence: 99%

Lichen planus pemphigoides: two case reports

Swale

Black

Bhogal

1998

Clinical and Experimental Dermatology

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Section: Discussionmentioning

confidence: 99%

Lichen planus pemphigoides: two case reports

Swale

Black

Bhogal

1998

Clinical and Experimental Dermatology

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“…The clinical features were those of a ‘BP‐like disease’ with tense bullae and urticarial plaques without the mucosal involvement or ‘lichen planus‐like’ lesions usually observed in PNP. 10 Similarly, the histological picture of subepidermal bullae was reminiscent of BP, as acantholysis, keratinocyte necrosis and a lichenoid infiltrate suggestive of PNP were not observed. 11 The patient’s serum contained antidesmoplakin I–II antibodies as suggested by the IIF labelling of rat bladder and mouse myocardium, 9 which was confirmed by immunoblotting of epidermal and purified desmoplakin extracts, and IEM analysis that showed a labelling of desmosomal plaques.…”

Section: Discussionmentioning

confidence: 92%

A paraneoplastic mixed bullous skin disease: breakdown in tolerance to multiple epidermal antigens

Musette¹,

Joly

Gilbert

et al. 2000

British Journal of Dermatology

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We report a new type of paraneoplastic mixed bullous skin disease in a patient with a B-cell lymphoma associated with monoclonal IgM kappa paraproteinaemia. The patient's clinical and histological features were reminiscent of bullous pemphigoid. Characterization of antiepidermal antibodies by immunoblotting and indirect immunoelectron microscopy demonstrated a novel pattern of reactivity: IgG antibodies were directed against desmoplakins I-II and BPAG2, and were associated with antidesmoglein 3 polyclonal IgM antibodies. Such an autoreactive pattern involving antidesmoplakins, anti-BPAG2 and antidesmoglein 3 antibodies has not been previously reported. It reflects the breakdown of tolerance to multiple epidermal antigens observed in some patients with malignancy.

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“…Nikolsky sign can occasionally be elicited 5 . PNP spectrum also includes, a lichen planus pemphigoid‐like eruption that can precede or follow the symptoms of the neoplasm 5–10 . Blisters and lichenoid lesions on the palms and soles are frequently seen, helping to differentiate it from pemphigus vulgaris.…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic pemphigus with clinical features of lichen planus associated with low‐grade B cell lymphoma

et al. 2005

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Background Neoplasia-induced lichen planus is described as a cell-mediated reaction to unknown epithelial antigens. Paraneoplastic pemphigus (PNP), characterized by the presence of a specific array of autoantibodies, probably represents a different form of presentation of the same autoimmune syndrome where the mucocutaneous expression depends on the dominant pathologic mechanism. Conclusion PNP has different forms of presentation and the lack of a consensus about diagnostic criteria may contribute to underdiagnosed cases. Advances on the knowledge of the sensitivity and specificity of diagnostic criteria have allowed a better accuracy of diagnosis. Methods

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Paraneoplastic Pemphigus Presenting as a Lichen Planus Pemphigoides—like Eruption

Cited by 75 publications

References 24 publications

Lichen planus pemphigoides: two case reports

Lichen planus pemphigoides: two case reports

A paraneoplastic mixed bullous skin disease: breakdown in tolerance to multiple epidermal antigens

Paraneoplastic pemphigus with clinical features of lichen planus associated with low‐grade B cell lymphoma

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