Paraneoplastic opsoclonus-myoclonus associated with renal cell carcinoma and responsive to tumour ablation

Vigliani, Maria Claudia; Palmucci, L.; Polo, P. Huici; Mutani, R; Schiffer, D; Luca, Stefano De; Zan, A. De

doi:10.1136/jnnp.70.6.814

Cited by 22 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, we highlight that failure to identify an antibody marker should not exclude a paraneoplastic process [ 22 , 23 ], particularly if resolution of the neurologic syndrome follows the removal of the tumor. Of the 22 cases of paraneoplastic neurologic syndromes associated with RCC, 10 patients were not screened for paraneoplastic antibodies and 8 were negative for all antibodies tested [ 2 , 4 , 9 , 15–17, 19 , 20 ]. Of those who tested positive, all were nonspecific including 3 that were positive for antinuclear antibody at 1: 80 [ 21 , 24 , 25 ] and 1 who was positive for anti-GAD [ 14 ].…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Paraneoplastic Peripheral Nervous System Manifestations of Renal Cell Carcinoma: A Case Report and Review of the Literature

2017

View full text Add to dashboard Cite

Neurologic symptoms secondary to a paraneoplastic syndrome may be the presenting manifestation of a previously undiagnosed cancer, and alertness to these syndromes may provide an opportunity for early detection and treatment of a cancer. Paraneoplastic weakness is a rare manifestation of renal cell carcinoma and may present with variable electrophysiological features. We present a case of a patient with progressive weakness, sensory changes, and urinary retention, with electrophysiological features suggestive of a complex peripheral nervous system syndrome. Ultimately, a renal cell mass was detected and resected, resulting in significant clinical improvement. We review the literature, cataloging the known neurologic syndromes and antibodies associated with renal cell carcinoma. This case highlights that paraneoplastic neurological disorders associated with RCC can take on many features and provides a resource to practitioners for early detection of a neurologic paraneoplastic syndrome arising from renal cell carcinoma.

show abstract

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Paraneoplastic Peripheral Nervous System Manifestations of Renal Cell Carcinoma: A Case Report and Review of the Literature

2017

View full text Add to dashboard Cite

show abstract

“…Our patient received steroids, IVIG, plasmaphoresis, and tacrolimus without improvement in her condition. Finally, some patients have noted an improvement with treatment of the primary tumor, but usually only if complete eradication can be achieved (46) .…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic cerebellar degeneration in ovarian carcinoma: case report with review of immune modulation

Bradley

Dottino

Rahaman

2008

Int J Gynecol Cancer

View full text Add to dashboard Cite

Paraneoplastic cerebellar degeneration (PCD) is a rare nonmetastatic complication of a carcinoma. It is typically mediated by antibodies generated against tumor antigens. These antigens are the same proteins as expressed on Purkinje cells within the cerebellum; immune activation in the central nervous system (CNS) results in the syndrome. A 56-year-old woman with stage IIIC serous ovarian carcinoma diagnosed 3 years prior developed progressive limb ataxia. Serum anti-Yo antibodies were positive, confirming the diagnosis of PCD. Treatment with plasmaphoresis, intravenous immune globulin, and immune modulation with corticosteroids and tacrolimus was unsuccessful. Although the syndrome can be debilitating and treatment options are limited, it may also be an example of a successful host immune response in certain cases.

show abstract

“…12 Previously reported paraneoplastic neurological disorders with renal carcinoma have included frontal lobe disorder and ataxia, 12 bilateral diaphragm paralysis, 13 limbic encephalitis 14,15 a motor neuron disease-like syndrome, 16 myopathy 17 and the opsoclonus-myoclonus syndrome. 18 …”

Section: Discussionmentioning

confidence: 99%

Clear cell carcinoma of the kidney in a young man with neurological complications

et al. 2007

View full text Add to dashboard Cite

Paraneoplastic opsoclonus-myoclonus associated with renal cell carcinoma and responsive to tumour ablation

Cited by 22 publications

References 5 publications

Paraneoplastic Peripheral Nervous System Manifestations of Renal Cell Carcinoma: A Case Report and Review of the Literature

Paraneoplastic Peripheral Nervous System Manifestations of Renal Cell Carcinoma: A Case Report and Review of the Literature

Paraneoplastic cerebellar degeneration in ovarian carcinoma: case report with review of immune modulation

Clear cell carcinoma of the kidney in a young man with neurological complications

Contact Info

Product

Resources

About