Paraneoplastic neurological syndromes of the central nervous system: a single institution 7-year case series

Giammello, Fabrizio; Galletta, Karol; Grillo, Francesco; Brizzi, Teresa; Cavallaro, Marco; Mormina, Enricomaria; Scelzo, Emma; Allegra, Cosimo; Stancanelli, Claudia; Rodolico, Carmelo; Musumeci, Olimpia; Toscano, Antonio; Granata, Francesca

doi:10.1007/s13760-023-02232-y

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…These antibodies are not considered directly pathogenic but act as targets for cytotoxic T-cell infiltration through cross-reactive intracellular epitopes [8]. Patients typically do not respond well to standard immunomodulatory treatments; tumor treatment remains the primary line of therapy [9]. Due to their life-threatening complications, we employed steroids as rescue bridging therapy in both cases until definitive treatment (surgical excision, chemotherapy, or radiation treatment) could be initiated.…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic neurological syndrome associated with onconeural autoantibodies: report of two cases

Kalmoukos,

Kouparani,

Moscha

et al. 2024

Precis Future Med

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Paraneoplastic neurological syndromes (PNS) are rare and often severe neurological complications of malignancies, significantly impacting patient prognosis and quality of life. They are characterized by a diverse range of onconeural autoantibodies, with further discoveries likely due to ongoing research. Among these, high-risk autoantibodies primarily target intracellular neural cell antigens. We present cases of lung cancer patients who developed limbic encephalitis and seizures at diagnosis, suggestive of PNS. Each case demonstrated distinct autoantibody profiles. Recognition of these potentially life-altering neurological sequelae, as paraneoplastic manifestations of malignancies, is crucial for physicians. PNS may precede primary cancer diagnosis and substantially affect patient presentation and overall outcome. We provide in detail the diagnostic work-up and available treatment options for these complex cases.

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Section: Discussionmentioning

confidence: 99%