Paraneoplastic myopathy in pancreatic cancer: a case report and literature review

Padniewski, Jessica; Nelson, Elizabeth A.; Mian, Istiaq; Laczniak, Andrew; Ives, Samuel T; Nasr, Rawad

doi:10.1080/20009666.2021.1982487

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…The spectrum of tumors linked to DM or PM mirrors the distribution observed in the broader population, with the potential deviations being a heightened occurrence of cervical (14), lung (15), ovarian (16), pancreatic (17), bladder (18), and gastric carcinomas (19), as well as non-Hodgkin lymphoma (20). The occurrence of cancer can be ascertained prior to, during, or subsequent to the diagnosis of myositis, with a notable surge in frequency observed within the two-year timeframe encompassing the onset and progression of myositis.…”

Section: Disscussionmentioning

confidence: 82%

Inflammatory myopathy in the proximal lower limb: Rare presentation of lymphoma

pourbagherian,

Hajialilo,

vahedi

et al. 2023

Preprint

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Section: Disscussionmentioning

confidence: 82%

Inflammatory myopathy in the proximal lower limb: Rare presentation of lymphoma

pourbagherian,

Hajialilo,

vahedi

et al. 2023

Preprint

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“…All of the patients reported in Table 1 received steroids except for one. It has been reported that lack of response to steroid therapy may indicate underlying malignancy, thus, indicating the need for further investigation [ 4 ]. Furthermore, treatment of underlying malignancy may improve myopathy symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…The close temporal relationship between polymyositis onset and diagnosis of malignancy and improvement of symptoms with paraneoplastic syndrome treatment suggests a further association [ 3 ]. More specifically, polymyositis has been reported to occur as paraneoplastic syndromes in patients with lymphoma, breast, lung, and bladder cancers [ 4 ]. Paraneoplastic polymyositis is rarely associated with pancreatic adenocarcinoma, with less than a handful of documented cases.…”

Section: Introductionmentioning

confidence: 99%

Not a Statin-Induced Myopathy: Metastatic Pancreatic Adenocarcinoma Presenting As Paraneoplastic Myositis

Ozcan¹,

Shaikh²,

Becker³

et al. 2022

Cureus

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Polymyositis is an inflammatory disease that causes bilateral proximal muscle weakness; unlike dermatomyositis, it is not usually associated with malignancy. However, there are a handful of case reports documenting polymyositis in patients with lymphoma, breast, lung, and bladder cancer. Here we report a case of metastatic pancreatic adenocarcinoma disguised by presenting as polymyositis. Clinical presentation, laboratory values, muscle biopsy, and imaging were all diagnostic of paraneoplastic polymyositis. The patient has significantly improved in symptoms are receiving systemic steroids and pancreaticoduodenectomy.

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Paraneoplastic myopathy-related rhabdomyolysis and pancreatic cancer: A case report and review of the literature

Costantini,

Moletta,

Pierobon

et al. 2023

World J Clin Cases

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β cells are the main cells responsible for the hypoglycemic function of pancreatic islets, and the insulin secreted by these cells is the only hormone that lowers blood glucose levels in the human body. β cells are regulated by various factors, among which neurotransmitters make an important contribution. This paper discusses the effects of neurotransmitters secreted by various sympathetic and parasympathetic nerves on β cells and summarizes the mechanisms by which various neurotransmitters regulate insulin secretion. Many neurotransmitters do not have a single source and are not only released from nerve terminals but also synthesized by β cells themselves, allowing them to synergistically regulate insulin secretion. Almost all of these neurotransmitters depend on the presence of glucose to function, and their actions are mostly related to the Ca2+ and cAMP concentrations. Although neurotransmitters have been extensively studied, many of their mechanisms remain unclear and require further exploration by researchers.

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Paraneoplastic myopathy in pancreatic cancer: a case report and literature review

Cited by 4 publications

References 32 publications

Inflammatory myopathy in the proximal lower limb: Rare presentation of lymphoma

Inflammatory myopathy in the proximal lower limb: Rare presentation of lymphoma

Not a Statin-Induced Myopathy: Metastatic Pancreatic Adenocarcinoma Presenting As Paraneoplastic Myositis

Paraneoplastic myopathy-related rhabdomyolysis and pancreatic cancer: A case report and review of the literature

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