Paraneoplastic limbic encephalitis in a patient with extensive disease small-cell lung cancer

Ochenduszko, Sebastián; Wilk, Bartosz; Dąbrowska, Jolanta; Herman‐Sucharska, Izabela; Dubis, Anna; Püsküllüoğlu, Mirosława

doi:10.3892/mco.2017.1162

Cited by 3 publications

(2 citation statements)

References 20 publications

(33 reference statements)

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“…3,4 Anti-Hu and anti-Ma2 are the antibodies responsible for approximately 60% of PLE cases, 5 with anti-Hu being specific for SCLC. 6,7 Serum anti-Hu titers were positive in our patient and supported a PLE diagnosis. MRI findings are a traditional criterion for diagnosing limbic encephalitis.…”

supporting

confidence: 73%

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18F-FDG PET and MRI Evaluation of Paraneoplastic Limbic Encephalitis

2023

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Autoimmune limbic encephalitis (paraneoplastic or nonparaneoplastic) is a rare condition involving autoantibodies against intracellular or cell-surface proteins of neurons. Patients typically present with acute and progressive neuropsychiatric symptoms. Although the criterion standard for diagnosis remains detection of autoantibodies in cerebrospinal fluid, there are characteristic imaging features that can aid in diagnosis, notably abnormalities in the bilateral medial temporal lobes on imaging, particularly with nuclear imaging. Here, we present 18F-FDG PET findings of paraneoplastic limbic encephalitis in a 65-year-old man.

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supporting

confidence: 73%

“…Among patients with PLE, lung cancer is implicated in 40%–50% of cases 3,4 . Anti-Hu and anti-Ma2 are the antibodies responsible for approximately 60% of PLE cases, 5 with anti-Hu being specific for SCLC 6,7 . Serum anti-Hu titers were positive in our patient and supported a PLE diagnosis.…”

supporting

confidence: 59%

18F-FDG PET and MRI Evaluation of Paraneoplastic Limbic Encephalitis

2023

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Cognitive Impairment in Lung Cancer and Brain Metastases

Niccolai¹,

Rexer²

2023

Lung Cancer Rehabilitation

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A Journey from Schizophrenia to Paraneoplastic Limbic Encephalitis

Satapathy,

Behuria

2023

IJRSMS

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A 58-year female presented with behavioral changes, dementia, and hallucinations for which she was initially treated as a case of schizophrenia. Later she developed hypersomnolence, speech difficulty and urinary incontinence. She also developed seizures later. On investigations cerebrospinal fluid (CSF) cell count was high and chest x-ray revealed homogeneous opacity over the left upper and midzone. Contrast-enhanced computerized tomography (CECT) Thorax revealed apical segment collapse consolidation with air bronchogram and bilateral pleural effusion. Multiple hepatic and bony metastasis s/o primary bronchoalveolar carcinoma. Osteolytic lesions were also found on skull x-ray and on pelvis x-ray. Tissue diagnosis couldn’t be done as the patient’s general condition deteriorated and the patient left against medical advice. From the above clinical picture and investigation findings, it was diagnosed as a case of paraneoplastic limbic encephalitis.

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Paraneoplastic limbic encephalitis in a patient with extensive disease small-cell lung cancer

Abstract: Abstract. Paraneoplastic limbic encephalitis (PLE) is a rare disorder infrequently accompanying malignancy, coexisting in ~50% of the cases with small-cell lung cancer

Cited by 3 publications

References 20 publications

18F-FDG PET and MRI Evaluation of Paraneoplastic Limbic Encephalitis

18F-FDG PET and MRI Evaluation of Paraneoplastic Limbic Encephalitis

Cognitive Impairment in Lung Cancer and Brain Metastases

A Journey from Schizophrenia to Paraneoplastic Limbic Encephalitis

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