Paraneoplastic Hypoglycemia Due to an Insulin‐Like Growth Factor Type‐II Secreting Hepatocellular Carcinoma in a Dog

Zini, Eric; Glaus, T M; Minuto, Francesco; Arvigo, Marica; Hauser, B.; Reusch, Claudia E

doi:10.1111/j.1939-1676.2007.tb02946.x

Cited by 41 publications

(30 citation statements)

References 13 publications

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“…The most likely etiology of hypoglycemia was a paraneoplastic syndrome, as demonstrated by the inverse relationship between the presence of the mammary carcinoma and the serum glucose concentrations and the return of hyperglycemia following excision of the tumor. Paraneoplastic hypoglycemia has been reported in animals in association with different tumor types, including non‐β‐cell neoplasms such as leiomyoma or leiomyosarcoma, 4–6 hepatocellular carcinoma, 7 and renal carcinoma 8,9 . To our knowledge, the association between paraneoplastic hypoglycemia and mammary carcinoma has not been reported in dogs.…”

Section: Discussionmentioning

confidence: 90%

“…In people, carcinomas with ductal involvement frequently express IGF‐2 10,11 . The pathogenesis of hypoglycemia in these cases is related to aberrant production of insulin or, more frequently, of insulin‐like substances, such as IGF‐2, by tumor cells 7,12 . In addition, utilization of glucose by the tumor itself, especially in the case of large masses, and aberrant metabolism associated with specific localization of the tumor, hepatic dysfunction in the case of tumors in the liver, can contribute to development of hypoglycemia 13 .…”

Section: Discussionmentioning

confidence: 99%

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Paraneoplastic hypoglycemia in a diabetic dog with an insulin growth factor‐2–producing mammary carcinoma

Rossi

Errico²,

Perez³

et al. 2010

Veterinary Clinical Pathol

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A 6-year-old intact female Labrador Retriever had diabetes mellitus, which had been difficult to control with insulin. The dog also had a solid ductal mammary carcinoma with very rapid growth, which was temporally related to onset of hypoglycemia. Eight months after initial diagnosis of diabetes, the dog had a hypoglycemic crisis. Insulin administration was stopped and serum glucose concentration returned to normal. Three months after discontinuing insulin, another hypoglycemic crisis occurred. During subsequent months, serum glucose concentrations remained at life-threatening levels (1.64-2.12 mmol/L, reference interval 4.44-6.66 mmol/L) simultaneously with an increase in the size of the mammary tumor, which reached a diameter of about 16 cm. At the time of surgery for removal of the tumor serum glucose concentration was 2.20 mmol/L and was then monitored every 3 hours after excision of the tumor. The glucose concentration continued to rise and reached 9.99 mmol/L 12 hours after the removal of the mammary tumor. Immunohistochemical staining demonstrated expression of insulin growth factor-2 by tumor cells, which apparently had caused the hypoglycemia during tumor growth even in a diabetic dog. Hyperglycemia associated with diabetes was pronounced after excision of the tumor and had been masked by the paraneoplastic effect of the tumor.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Paraneoplastic hypoglycemia in a diabetic dog with an insulin growth factor‐2–producing mammary carcinoma

Rossi

Errico²,

Perez³

et al. 2010

Veterinary Clinical Pathol

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“…Hypoglycaemia is a common state in critically ill dogs and cats without endogenous or iatrogenic hyperinsulinaemia, such as those with a portosystemic shunt, paraneoplastic syndrome, neonatal hypoglycaemia, xylitol toxicity, or sepsis (Miller et al 1980;Dunayer 2004;Zini et al 2007;Collings et al 2012). When a hypoglycaemic event is not identified, the animal may experience seizure, critical brain damage, coma, and even death (Loose et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Comparison of continuous and intermittent glucose monitoring systems in a dog with diabetic ketoacidosis: a case report

Kim¹,

Kim²,

Kang³

et al. 2017

Vet. Med. - Czech

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ABSTRACT:A Miniature schnauzer (12 years old, neutered male) was referred for lethargy, anorexia, and oral bleeding. On initial evaluation, severe hyperglycaemia (blood glucose concentration of 34.9 mmol/l), ketonuria, systemic inflammation (fever, panting, left-shift neutrophilia, and a high C-reactive protein level of 980.97 nmol/l, abnormal pancreatic lipase immunoreactivity, and periodontitis were found. With consideration of possible insulin resistance, blood glucose (BG) levels were monitored using a portable glucose meter (q 1-3 h) and a continuous glucose monitoring system (CGMS) for 72 h (three consecutive trials); intensive insulin therapy was initiated using regular insulin (2.2 IU/kg intravenously). The insulin doses needed, based on the nadir, peak, and duration of insulin action from a traditional intermittent glucose curve were higher than those based on the CGMS results. Meanwhile, transient hyperglycaemic and hypoglycaemic periods, occurring between the intermittent measurements, were easily identified with the CGMS. Therefore, insulin resistance and the Somogyi phenomenon are less likely to occur with use of the CGMS than with intermittent BG measurements. By comparing data from a CGMS to those from an intermittent portable BG measurement system, this case report emphasises the importance and usefulness of a CGMS.

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“…Lipofuscin is more likely to be present in a higher percentage of hepatocytes in nonmalignant conditions compared with malignancy (Masserdotti and Drigo, 2012). A paraneoplastic hypoglycemia in association with hepatocellu lar carcinoma has been attributed to secretion of insulinlike growth factor type II (Zini et al, 2007).…”

Section: Neoplasia Hepatocellular Neoplasiamentioning

confidence: 99%

The Liver

Meyer¹

2016

Canine and Feline Cytology

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Paraneoplastic Hypoglycemia Due to an Insulin‐Like Growth Factor Type‐II Secreting Hepatocellular Carcinoma in a Dog

Cited by 41 publications

References 13 publications

Paraneoplastic hypoglycemia in a diabetic dog with an insulin growth factor‐2–producing mammary carcinoma

Paraneoplastic hypoglycemia in a diabetic dog with an insulin growth factor‐2–producing mammary carcinoma

Comparison of continuous and intermittent glucose monitoring systems in a dog with diabetic ketoacidosis: a case report

The Liver

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