Paraneoplastic Glomerular Diseases

A Case Report of Mediastinal Teratoma in a Pediatric Patient With Nephrotic Syndrome: Paraneoplastic Syndrome or Incidental Finding?

“…Membranous nephropathy is hypothesized to be the result of tumor inducing target auto-antigens that result in deposition of immune complexes into the glomerular membrane, thus resulting in the characteristic membrane thickening seen histologically in membranous nephropathy. Groundbreaking discoveries of target antigens specifically implicated in glomerular diseases and malignancy include thrombospondin type q domain containing protein 7A (THSD7A) and neural epidermal growth factor like 1 protein (NELL-1), both of which are target podocyte antigens that have been stained positive on case reports of solid tumors and suggest a causal link between solid tumor and paraneoplastic glomerulonephropathy 9 . To date, the mechanism of renal injury in paraneoplastic syndromes remains hypothetical rather than causal.…”

“…Groundbreaking discoveries of target antigens specifically implicated in glomerular diseases and malignancy include thrombospondin type q domain containing protein 7A (THSD7A) and neural epidermal growth factor like 1 protein (NELL-1), both of which are target podocyte antigens that have been stained positive on case reports of solid tumors and suggest a causal link between solid tumor and paraneoplastic glomerulonephropathy. 9 To date, the mechanism of renal injury in paraneoplastic syndromes remains hypothetical rather than causal.…”

Nephrotic syndrome: ethiological factors and differential diagnosis

“…По мнению P. Ronco, о паранеопластическом генезе гломерулонефрита свидетельствуют следующие факты: (1) достижение ремиссии гломерулонефрита после хирургического удаления опухоли или химиотерапии; (2) рецидив поражения почек при рецидиве опухоли; (3) установленная патофизиологическая связь между опухолью и гломерулонефритом, включая наличие антигенов опухоли или противоопухолевых антител в составе субэпителиальных отложений иммунных комплексов [62]. "Классическими" вариантами паранеопластического гломерулонефрита считают мембранозную нефропатию при солидных опухолях и БМИ при ходжкинской лимфоме, хотя злокачественные опухоли могут сопровождаться развитием и других вариантов гломерулопатий, проявляющихся НС, в том числе ФСГС, МПГН и IgAнефропатии [63,64].…”