Paraneoplastic erythema annulare centrifugum eruption as a cutaneous marker of squamous cell carcinoma of the lung

Mitic, T.; Adžić-Vukičević, Tatjana; Stojšić, Jelena; Dobrosavljevic, Danijela

doi:10.1111/jdv.16497

Cited by 4 publications

(5 citation statements)

References 7 publications

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“…10 Cuando el EAC se manifiesta como una dermatosis paraneoplásica, se le denomina eritema anular centrífugo paraneoplásico (PEACE, por sus siglas en inglés), y la recurrencia del mismo puede ser indicativa de recaída de la neoplasia subyacente. 11 Dentro de los reportes de casos en la literatura, encontramos dos con linfoma no Hodgkin, uno con linfoma de Hodgkin, uno con leucemia linfocítica aguda, uno con leucemia aguda promielocítica, tres casos de leucemia linfocítica crónica, uno con leucemia mieloide crónica, uno con histiocitosis maligna, uno con adenocarcinoma papilar seroso de ovario, dos con neoplasia pulmonar, uno con carcinoma de mama y cuatro con carcinoma recurrente o metastásico. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] Otros padecimientos asociados son las infecciones.…”

Section: Discussionunclassified

“…11 Dentro de los reportes de casos en la literatura, encontramos dos con linfoma no Hodgkin, uno con linfoma de Hodgkin, uno con leucemia linfocítica aguda, uno con leucemia aguda promielocítica, tres casos de leucemia linfocítica crónica, uno con leucemia mieloide crónica, uno con histiocitosis maligna, uno con adenocarcinoma papilar seroso de ovario, dos con neoplasia pulmonar, uno con carcinoma de mama y cuatro con carcinoma recurrente o metastásico. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] Otros padecimientos asociados son las infecciones. En la literatura consultada, encontramos un mayor núwww.medigraphic.com/dermatologicopascua www.medigraphic.org.mx cuadro dermatológico tras haber recibido manejo para la comorbilidad subyacente, con un promedio de 11 semanas entre el manejo y la resolución de la dermatosis.…”

Section: Discussionunclassified

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Eritema anular centrífugo como marcador cutáneo de comorbilidades

Acar¹,

Cruz²,

Rosas-Morett³

2021

Revista Del Centro Dermatológico Pascua

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Artículo de revisión INTRODUCCIÓNLos eritemas figurados se manifiestan clínicamente como diversas erupciones que adquieren una disposición anular y/o policíclica; algunas de éstas son fijas, aunque la mayor parte de ellas son migratorias. Muchas de estas afecciones parecen relacionarse con hipersensibilidad a fármacos, neoplasias, infecciones, picaduras de artrópodos o por constituyentes propios

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Section: Discussionunclassified

Eritema anular centrífugo como marcador cutáneo de comorbilidades

Acar¹,

Cruz²,

Rosas-Morett³

2021

Revista Del Centro Dermatológico Pascua

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“…EAC is a rare reactive erythema associated with annular, erythematous plaques with an associated trailing scale. EAC associated with underlying malignancy, termed PEACE, is exceedingly rare [ 2 ]. The exact pathophysiological correlation between the metastatic disease and EAC is yet to be understood, but cytokine and/or antigen stimulation in the development of the dermatoses has been proposed [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Erythema annulare centrifugum (EAC) is a chronic reactive form of annular erythema that appears as an urticaria-like papule and enlarges centrifugally, then clears centrally [ 1 , 2 ]. It is thought to be a type IV hypersensitivity reaction to various conditions, including infections, drug exposures, food exposures, autoimmune disease, and malignancy [ 2 , 3 ]. It can also be idiopathic.…”

Section: Introductionmentioning

confidence: 99%

Paraneoplastic Erythema Annulare Centrifugum Eruption (PEACE) Associated With Metastatic Colorectal Adenocarcinoma

Pitchford¹,

Shenk²,

Zurowski³

et al. 2021

Cureus

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Erythema annulare centrifugum (EAC) is a figurate erythema presenting with annular, erythematous plaques with a trailing scale. It is considered a hypersensitivity reaction to a variety of antigens and is associated with multiple underlying causes including malignancy. Malignancy-associated EAC is termed paraneoplastic erythema annulare centrifugum eruption (PEACE). Although a specific etiology has yet to be elucidated, this form of EAC is likely to occur due to cytokine and/or antigen stimulation from an underlying malignancy. PEACE is primarily associated with lymphoproliferative disorders and rarely solid tumors. Our report discusses a case of PEACE associated with metastatic colorectal adenocarcinoma. On presentation to our clinic, the patient had developed a migratory annular eruption over a year. His review of symptoms was positive for signs of underlying malignancy, including weight loss and recent lower vertebral fracture. A biopsy of his annular lesion revealed a non-specific pityriasiform dermatitis. A vertebral biopsy uncovered a diagnosis of metastatic colorectal cancer. At that time, clinicopathologic correlation allowed us to reach the diagnosis of PEACE.

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“…Possible triggers may include viral, bacterial or fungal infections, medications, foods, malignancy or other systemic diseases. 1 , 2 , 5 However, in many patients, a specific trigger cannot be recognized. 6 Histopathologic findings in EAC consist of a dense perivascular lymphocytic infiltrate on papillary dermis and possibly reticular dermis, which is known as a ‘coat sleeve’ appearance.…”

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confidence: 99%