Paraneoplastic Eosinophilia in Clear Cell Renal Cell Carcinoma

Zhou, Weiwei; Guan, Youyan; Liu, Xinmin

doi:10.4103/0366-6999.162501

Cited by 5 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, eosinophilia associated with renal cell cancer is exceedingly rare. So far, only two cases of CCRCC ( 4 , 5 ) and three with chromophobe RCC associated with hypereosinophilia ( 27 ) have been reported ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hypereosinophilia in Solid Tumors—Case Report and Clinical Review

2021

View full text Add to dashboard Cite

BackgroundRenal cell cancer may cause various paraneoplastic syndromes; however, paraneoplastic hypereosinophilia occurs exceedingly rare. Thus far, only two cases of clear cell renal cell carcinoma (CCRCC) associated with hypereosinophilia have been reported. In this paper, we present a case of paraneoplastic hypereosinophilia associated with renal cell carcinoma and a review of the reported cases of hypereosinophilia in solid tumors.MethodsThe review is based on an electronic literature search performed in the PubMed database in September 2020 with the following key terms: eosinophilia & neoplasm; eosinophilia & cancer; eosinophilia & paraneoplastic syndrome. Papers were included based on screening the titles and/or abstracts. We also included the case of our patient in the analysis.Case presentationA 68-year-old Caucasian female patient with recurrent CCRCC was admitted to our Clinic for exacerbating dyspnea and chest and right upper abdominal pain, accompanied by confusion. Preliminary blood tests showed an increased white blood cell count of 40,770/μl, and an increased eosinophil count of 6,530/μl indicating eosinophilia. Several tests were carried out to rule out the noncancer causes of hypereosinophilia. The temporal appearance of eosinophilia and the recurrence of CCRCC without any other apparent potential causes led to the diagnosis of paraneoplastic hypereosinophilia. Despite treating with high doses of corticosteroids, only a transient decrement in eosinophil count was observed along with further deterioration of the patient’s condition. The patient succumbed to the disease 6 months following the tumor surgery and 2 months after the diagnosis of hypereosinophilia and tumor recurrence.ConclusionOur observations are in agreement with the majority of reports showing that the occurrence of eosinophilia following tumor resection may indicate a poor prognosis, tumor recurrence, and rapid disease progression.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Papers were included based on screening the titles and/or abstracts. So far, only two cases of CCRCC associated with TABE have been reported ( 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Hypereosinophilia in Solid Tumors—Case Report and Clinical Review

2021

View full text Add to dashboard Cite

show abstract

“…RCC can induce various paraneoplastic syndromes, such as hypercalcemia, arterial hypertension, or production of erythropoietin [249,250,251]. Paraneoplastic PBE is rarely described in RCC and restricted to case reports of patients with different RCC-subtypes, such as clear cell RCC and chromophobe RCC but mostly appears to reflect an advanced disease phase with widespread metastasis [252,253,254,255,256].…”

Section: Eosinophilia In Kidney Diseasementioning

confidence: 99%

Eosinophilia and Kidney Disease: More than Just an Incidental Finding?

Gauckler

Smıth

Mayer

et al. 2018

JCM

View full text Add to dashboard Cite

Peripheral blood eosinophilia (PBE), defined as 500 eosinophils or above per microliter (µL) blood, is a condition that is not uncommon but often neglected in the management of patients with chronic kidney disease (CKD), acute kidney injury (AKI), or patients on renal replacement therapy (RRT). The nature of PBE in the context of kidney diseases is predominantly secondary or reactive and has to be distinguished from primary eosinophilic disorders. Nonetheless, the finding of persistent PBE can be a useful clue for the differential diagnosis of underdiagnosed entities and overlapping syndromes, such as eosinophilic granulomatosis with polyangiitis (EGPA), IgG4-related disease (IgG4-RD), acute interstitial nephritis (AIN), or the hypereosinophilic syndrome (HES). For patients on RRT, PBE may be an indicator for bio-incompatibility of the dialysis material, acute allograft rejection, or Strongyloides hyperinfection. In a subset of patients with EGPA, eosinophils might even be the driving force in disease pathogenesis. This improved understanding is already being used to facilitate novel therapeutic options. Mepolizumab has been licensed for the management of EGPA and is applied with the aim to abrogate the underlying immunologic process by blocking interleukin-5. The current article provides an overview of different renal pathologies that are associated with PBE. Further scientific effort is required to understand the exact role and function of eosinophils in these disorders which may pave the way to improved interdisciplinary management of such patients.

show abstract