Paraneoplastic digital ischemia in clear-cell renal-cell carcinoma: Report of a case and review of the literature

Abstract

Digital ischemia has been rarely associated, as a paraneoplastic syndrome, with renal cancer. Since it can severely compromise the patients’ quality of life, early recognition is important, in order to optimally address it with currently available treatment options, such as tyrosine inhibitors. Digital ischemia may occur in the general population and it can be the result of other non-cancerous diseases; accordingly, a thorough and aggressive work-up is mandatory, together with appropriate therapeutic steps such as tyrosine kinase inhibitors, vasodilators, and antiaggregants. Herein, we report a 78-year-old male patient with a history of clear-cell renal-cell cancer, who presented in the emergency department with critical ischemia in the upper limbs.

Acute myocardial infarction and arterial embolism in a patient with newly diagnosed renal mass: management dilemmas! A case report

“…Few cases of acute digital ischaemia have been described showing classical symptoms of Raynaud’s phenomenon. In these patients, tumor progression is more aggressive compared to the average patient cohort [ 10 ]. In another report, a fatal outcome of pulmonary tumor thrombotic microangiopathy based on a papillary RCC was identified, in which tumorous microemboli formed in the pulmonary arterioles and subsequently lead to right heart failure [ 11 ].…”