Paraneoplastic dermatomyositis and prostate cancer: myopathy regression under cancer-directed therapy

Baleiras, Mafalda Miranda; Maduro, Luís; Vasques, Carolina; Ferreira, Filipa; Pinto, M.; Martins, Ana

doi:10.4081/dr.2021.9262

Cited by 2 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the effective treatment of tumors, the symptoms and signs of dermatomyositis can be improved, while the symptoms are aggravated when the tumor progresses. [ 14 , 15 ] Before being admitted, the patient had discovered a mediastinal lump that was perhaps a thymoma with no metastases and no evident rash or weakness of the muscles. Multiple metastases of thymoma along with obvious symptoms and signs of dermatomyositis occurred in this admission, which suggested that the progress of dermatomyositis were closely related to the tumor.…”

Section: Discussionmentioning

confidence: 99%

A case report of dermatomyositis mimicking myasthenia gravis

Jin,

Tao,

Wang

2023

Medicine

View full text Add to dashboard Cite

Rationale: Patients who have myasthenia gravis or dermatomyositis show clinical signs of muscular weakening. Ocular muscle involvement is uncommon, and symmetrical proximal limb weakness is the typical presentation of dermatomyositis. However, the earliest and most noticeable sign in those with myasthenia gravis is extraocular muscular paralysis. Dermatomyositis is frequently complicated by malignancy, and the common malignancies associated with dermatomyositis vary by region and ethnicity, while thymoma is relatively rare. About 10% to 15% of people with myasthenia gravis have thymoma, which is involved in the etiology of the disease. Patient concerns: A 68-year-old female presented with ocular muscle weakness for 10 days that manifested as bilateral blepharoptosis with the phenomenon of “light in the morning and heavy in the evening.” Imaging examination showed anterior mediastinal thymic tumor with metastasis. Diagnoses: After a thorough physical examination, we discovered bilateral upper limbs with grade IV muscle strength and the typical rash of dermatomyositis. In combination with elevated serum kinase levels and electromyography suggesting myogenic damage, the patient was finally diagnosed as dermatomyositis with multiple metastases of thymoma. Interventions: The patient received oral hydroxychloroquine sulfate, topical corticosteroids, and tacrolimus ointment, but these did not work very well. Subsequently, the patient underwent surgery combined with radiotherapy for the thymoma. Outcomes: Muscle weakness in the patient improved after effective treatment of tumor, and the rash mostly disappeared. Conclusion: Ocular muscle weakness and thymoma are more common in myasthenia gravis, but we cannot ignore the possibility of dermatomyositis. To further establish the diagnosis, a thorough physical examination and laboratory findings are required. Further tumor screening should be performed for patients with dermatomyositis. Early detection and management of possible tumors are essential to the treatment of dermatomyositis linked to malignancies.

show abstract

Section: Discussionmentioning

confidence: 99%

A case report of dermatomyositis mimicking myasthenia gravis

Jin,

Tao,

Wang

2023

Medicine

View full text Add to dashboard Cite

show abstract

“…The following are available online at : Supplementary Material S1: PRISMA 2020 Checklist [ 54 ]; Supplementary Material S2: List of Excluded Studies [ 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 ].…”

mentioning

confidence: 99%

Paraneoplastic Syndromes in Neuroendocrine Prostate Cancer: A Systematic Review

Abufaraj,

Ramadan,

Alkhatib

2024

Current Oncology

View full text Add to dashboard Cite

Neuroendocrine prostate cancer (NEPC) is a rare subtype of prostate cancer (PCa) that usually results in poor clinical outcomes and may be accompanied by paraneoplastic syndromes (PNS). NEPC is becoming more frequent. It can initially manifest as PNS, complicating diagnosis. Therefore, we reviewed the literature on the different PNS associated with NEPC. We systematically reviewed English-language articles from January 2017 to September 2023, identifying 17 studies meeting PRISMA guidelines for NEPC and associated PNS. A total of 17 articles were included in the review. Among these, Cushing’s Syndrome (CS) due to ectopic Adrenocorticotropic hormone (ACTH) secretion was the most commonly reported PNS. Other PNS included syndrome of inappropriate Anti-Diuretic Hormone secretion (SIADH), Anti-Hu-mediated chronic intestinal pseudo-obstruction (CIPO), limbic encephalitis, Evans Syndrome, hypercalcemia, dermatomyositis, and polycythemia. Many patients had a history of prostate adenocarcinoma treated with androgen deprivation therapy (ADT) before neuroendocrine features developed. The mean age was 65.5 years, with a maximum survival of 9 months post-diagnosis. NEPC is becoming an increasingly more common subtype of PCa that can result in various PNS. This makes the diagnosis and treatment of NEPC challenging. Further research is crucial to understanding these syndromes and developing standardized, targeted treatments to improve patient survival.

show abstract

Paraneoplastic dermatomyositis and prostate cancer: myopathy regression under cancer-directed therapy

Cited by 2 publications

References 18 publications

A case report of dermatomyositis mimicking myasthenia gravis

A case report of dermatomyositis mimicking myasthenia gravis

Paraneoplastic Syndromes in Neuroendocrine Prostate Cancer: A Systematic Review

Contact Info

Product

Resources

About