Paraneoplastic Cerebellar Degeneration in Nasopharyngeal Carcinoma: a Unique Association

Bhardwaj, Sharonlin; Khasani, Sina; Benasher, Daniel; Stein, Evan G.; Meghal, Trishala; Jacoby, Nuri; Huang, Yiwu

doi:10.1007/s12311-019-01045-1

Cited by 6 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A literature review of paraneoplastic neurological syndrome in NPC found one other case describing neurological symptoms preceding NPC diagnosis. A middle-aged man presented with progressive lower limb weakness, weight loss and gaze-evoked nystagmus with saccades 4. Serum anti-Yo antibodies were positive and MRI imaging of the brain found leptomeningeal enhancement around the cerebellum and oculomotor nerves.…”

Section: Discussionmentioning

confidence: 99%

Opsoclonus-myoclonus paraneoplastic syndrome in nasopharyngeal carcinoma

et al. 2022

View full text Add to dashboard Cite

Nasopharyngeal carcinoma can present with epistaxis, cervical lymphadenopathy, audiological symptoms secondary to eustachian tube dysfunction, pain, or neurological symptoms from tumours directly invading the skull base. It is unusual for patients to present with indirect systemic manifestations. Paraneoplastic neurological syndrome can precede clinically overt malignancy by up to 5 years; therefore, a combination of thorough clinical, laboratory and radiological investigations is required to reach a diagnosis. Intravenous immunoglobulin and steroids might improve neurological symptoms initially and prevent irreversible neuronal damage, but treatment of the underlying cancer is important for long-term resolution. Our case adds to a small but growing body of literature related to anti-Ri antibodies, opsoclonus-myoclonus syndrome presentations, and is the first reported association of this combination with nasopharyngeal carcinoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Opsoclonus-myoclonus paraneoplastic syndrome in nasopharyngeal carcinoma

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Revolutionary highthroughput DNA sequencing has become a promising and indispensable technique to study cancer [7] . On rare occasions, patient presents with a PCD months to years before cancer is diagnosed [8,9] . Therefore, whether the detection of certain mutations is available for clinical use in the ultra-early diagnosis of patients with PCD is worthy of further investigation.…”

Section: Case Reportmentioning

confidence: 99%

Paraneoplastic cerebellar degeneration associated with somatic mutations in ultra-early diagnosis of small cell lung cancer: a case report

Shi¹,

Li²,

He³

et al. 2020

View full text Add to dashboard Cite

Paraneoplastic cerebellar degeneration (PCD) can occur in patients with underlying cancer, such as small cell lung cancer (SCLC). Anti-CV2/CRMP5 antibodies are well-established biomarkers of PCD associated with SCLC, but cannot be detected in most situations. Recently, next-generation sequencing has been a promising technology to discover cancerdriven mutations, which provide an alternative strategy to accomplish ultra-early diagnosis of those patients. Here, we report the case of a 75-year-old man diagnosed with SCLC, who primarily presented with anti-CV2/CRMP5 antibodies positive PCD. Eight high-frequency gene mutations (TSC2 , DNMT1 , CIC , FGF6 , NSD1 , TSHR , CRLF2 , and EPPK1 ) were detected 7 months before diagnosis with no abnormalities of imaging or cerebrospinal fluid examination found initially. Therefore, this case suggests the possibility of detecting certain somatic mutations for the ultra-early diagnosis of patients presenting with PCD associated with SCLC.

show abstract

“…Many patients become disabled because of a severe progressive ataxia. In early stages, MRI imaging is often normal, although in some cases a cerebellar FLAIR hyperintensity has been reported [1][2][3].Cerebellar atrophy is the main neuroradiological nding and is usually observed later in the course of the disease. Contrast enhancement of the cerebellar cortex is very rare, having been described only in a patient with non-Hodgkin's lymphoma and PCD with anti-Tr antibodies [4].…”

Section: Introductionmentioning

confidence: 99%

Paraneoplastic Cerebellar Degeneration Associated with Anti-Yo Antibodies Appearing as a Leptomeningeal Cerebellar Carcinomatosis at MRI: a Case Report

Napolitano

Ranieri

Alfieri

et al. 2021

SN Compr. Clin. Med.

View full text Add to dashboard Cite

Anti Yo antibodies (AYA) are the antibodies most frequently identi ed with Paraneoplastic Cerebellar Degeneration (PCD). They are detected above all in PCD associated with breast and gynecologic malignancies. Here, we report a third case of PCD with cerebellar contrast enhancement ndings at MRI.In fact, AYA cross anti cerebellar cortex immune reaction leads mainly to hyperintensity signals in T2weighted-MRI sequences, followed by cerebellar atrophy. As such, meningeal contrast enhancement could lead to a diagnostic pitfall as it can be considered a carcinomatosis -above all in serum antibody negative cases as well as when a metastatic tumour is found. Our patient had no tumoral cells in the cerebrospinal uid and her neurological syndrome remained stable after immunoglobulin treatment.AYA serum nding was diriment for PCD diagnosis.

show abstract

Paraneoplastic Cerebellar Degeneration in Nasopharyngeal Carcinoma: a Unique Association

Cited by 6 publications

References 14 publications

Opsoclonus-myoclonus paraneoplastic syndrome in nasopharyngeal carcinoma

Opsoclonus-myoclonus paraneoplastic syndrome in nasopharyngeal carcinoma

Paraneoplastic cerebellar degeneration associated with somatic mutations in ultra-early diagnosis of small cell lung cancer: a case report

Paraneoplastic Cerebellar Degeneration Associated with Anti-Yo Antibodies Appearing as a Leptomeningeal Cerebellar Carcinomatosis at MRI: a Case Report

Contact Info

Product

Resources

About