Paramutation: From Maize to Mice

Chandler, Vicki L.

doi:10.1016/j.cell.2007.02.007

Cited by 238 publications

(189 citation statements)

References 19 publications

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“…Variations in a DNA methylation pattern can also be inherited between generations, and examples of this include paramutations in plants (interaction between alleles that leads to a directed epigenetic heritable change in one of the interacting alleles [Brink 1973;Chandler 2007]); silencing of foreign duplicated sequences in fungi (Allshire and Selker 2007); variations in telomeric, centromeric, and rRNA regions (Karpen and Hawley 2007); and variations in transgenes and endogenous genes. Specific examples of all these types of transgenerational inheritance are presented in Table 1.…”

Section: Mechanisms Of Cellular Epigeneticmentioning

confidence: 99%

Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

Jablonka

Raz²

2009

The Quarterly Review of Biology

1,384

1,172

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Section: Mechanisms Of Cellular Epigeneticmentioning

confidence: 99%

Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

Jablonka

Raz²

2009

The Quarterly Review of Biology

1,384

1,172

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“…So far, paramutation in maize has been studied at four loci: r1, b1, p1 and pl1, all involved in the regulation of anthocyanin and flavonoid biosynthesis (reviewed in Chandler et al, 2000). For these genes, reduced pigmentation linked to the paramutated allele correlates with reduced mRNA level and in the case of b1 locus is associated with RNAi phenomena (Das and Messing, 1994;Lund et al, 1995;Chandler et al, 2000;Sidorenko and Peterson, 2001;Della Vedova and Cone, 2004;Chandler and Stam, 2004;Stam and Scheid, 2005;Alleman et al, 2006;Chandler, 2007).…”

Section: Introductionmentioning

confidence: 99%

A paramutation phenomenon is involved in the genetics of maize low phytic acid1-241 (lpa1-241) trait

et al. 2008

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So far, in maize, three classes of mutants involved in phytic acid biosynthesis have been isolated: lpa1, lpa2 and lpa3. In 2007, a gene tagging experiment performed by Shi et al. found that mutations in ZmMRP4 (multidrug resistance-associated proteins 4) gene cause lpa1 phenotype. In previous studies, we isolated and described a single recessive lpa mutation (originally named lpa241), which was allelic to the lpa1-1 mutant, and was consequently renamed lpa1-241. It showed a decrease in the expression of the myo-inositol (Ins)-3-phosphate synthase gene (mips1S). In this study, we present genetic and molecular analyses of the lpa1-241 mutation that indicate an epigenetic origin of this trait, that is, a paramutagenic interaction that results in meiotically heritable changes in ZmMRP4 gene expression, causing a strong pleiotropic effect on the whole plant. The use of a 5-Azacytidine treatment provided data suggesting an association between gene methylation and the lpa1-241 phenotype. To our knowledge, this is the first report of a paramutagenic activity not involving flavonoid biosynthesis in maize, but regarding a key enzyme of an important metabolic pathway in plants.

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“…Paramutation has been found at several loci in maize, and at fewer loci in other species, including mice and humans [66]. MicroRNAs contribute to the mechanism of this trans-generational inheritance, establishment and maintenance of paramutations [7,67].…”

Section: Micrornasmentioning

confidence: 99%

Non-Coding RNAs: A Dynamic and Complex Network of Gene Regulation

Munshi¹,

Mohan²,

Yr³

2016

J Pharmacogenomics Pharmacoproteomics

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It has been estimated that less than two percent of the mammalian genome encodes proteins, rest of the genome which was earlier considered as junk DNA is the treasure trove of non-coding RNAs (ncRNAs). Many ncRNAs have now been characterized. They constitute one of the largest families of gene regulators that are found in plants and animals. They form a complex network and have key roles in diverse regulatory pathways involved in human health and disease. In this review, different types of ncRNAs, their biogenesis, structure, function and evolutionary significance is showcased.

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Paramutation: From Maize to Mice

Abstract: Paramutation is the epigenetic transfer of information from one allele of a gene to another to establish a state of gene expression that is heritable for generations. RNA has recently emerged as a prominent mediator of this remarkable phenomenon in both maize and mice.

Cited by 238 publications

References 19 publications

Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

A paramutation phenomenon is involved in the genetics of maize low phytic acid1-241 (lpa1-241) trait

Non-Coding RNAs: A Dynamic and Complex Network of Gene Regulation

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