Parametric study on mixing of two fluids in a three-dimensional serpentine microchannel

Ansari, Mubashshir Ahmad; Kim, Kwang‐Yong

doi:10.1016/j.cej.2008.10.006

Cited by 89 publications

(51 citation statements)

References 11 publications

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“…Their two types of design (Figures 13a and 13b) revealed much better mixing performance than the basic serpentine structure (Figure 13c) at low Reynolds numbers, implying that the basic serpentine microchannel is not suitable for low Reynolds-number flows. Further support for this argument was given by the numerical simulation of Ansari and Kim [29]. The two-layer structures proposed by Kim et al [27] and Xia et al [28] are shown to provide chaotic advection, but again the main disadvantage of those structures is that the fabrication of the two layers separately should increase the device price.…”

Section: Geometry Effectmentioning

confidence: 93%

A Review on Mixing in Microfluidics

2010

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Small-scale mixing is of uttermost importance in bio-and chemical analyses using micro TAS (total analysis systems) or lab-on-chips. Many microfluidic applications involve chemical reactions where, most often, the fluid diffusivity is very low so that without the help of chaotic advection the reaction time can be extremely long. In this article, we will review various kinds of mixers developed for use in microfluidic devices. Our review starts by defining the terminology necessary to understand the fundamental concept of mixing and by introducing quantities for evaluating the mixing performance, such as mixing index and residence time. In particular, we will review the concept of chaotic advection and the mathematical terms, Poincare section and Lyapunov exponent. Since these concepts are developed from nonlinear dynamical systems, they should play important roles in devising microfluidic devices with enhanced mixing performance. Following, we review the various designs of mixers that are employed in applications. We will classify the designs in terms of the driving forces, including mechanical, electrical and magnetic forces, used to control fluid flow upon mixing. The advantages and disadvantages of each design will also be addressed. Finally, we will briefly touch on the expected future development regarding mixer design and related issues for the further enhancement of mixing performance.

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Section: Geometry Effectmentioning

confidence: 93%

A Review on Mixing in Microfluidics

2010

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“…It is noted that the mixing index D I has been widely used to evaluate the quality of mixing [25,26], defined as:…”

Section: Parametric Analysismentioning

confidence: 99%

Density-induced asymmetric pair of Dean vortices and its effects on mass transfer in a curved microchannel with two-layer laminar stream

Xuan

Leung

et al. 2011

Chemical Engineering Journal

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“…The addition of the third dimension can drastically affect the flow field by the introduction of 3D vortices 12 leading to a more disturbed contact surface and increased contact time. Furthermore, by extending the channel length in the third dimension, building a compact micromixer in a limited workspace will become possible.…”

Section: Introductionmentioning

confidence: 99%

An easily fabricated three-dimensional threaded lemniscate-shaped micromixer for a wide range of flow rates

Rafeie

Welleweerd

Hassanzadeh-Barforoushi

et al. 2017

Biomicrofluidics

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Mixing fluid samples or reactants is a paramount function in the fields of micro total analysis system (lTAS) and microchemical processing. However, rapid and efficient fluid mixing is difficult to achieve inside microchannels because of the difficulty of diffusive mass transfer in the laminar regime of the typical microfluidic flows. It has been well recorded that the mixing efficiency can be boosted by migrating from two-dimensional (2D) to three-dimensional (3D) geometries. Although several 3D chaotic mixers have been designed, most of them offer a high mixing efficiency only in a very limited range of Reynolds numbers (Re). In this work, we developed a 3D fine-threaded lemniscate-shaped micromixer whose maximum numerical and empirical efficiency is around 97% and 93%, respectively, and maintains its high performance (i.e., >90%) over a wide range of 1 < Re < 1000 which meets the requirements of both the lTAS and microchemical process applications. The 3D micromixer was designed based on two distinct mixing strategies, namely, the inducing of chaotic advection by the presence of Dean flow and diffusive mixing through thread-like grooves around the curved body of the mixers. First, a set of numerical simulations was performed to study the physics of the flow and to determine the essential geometrical parameters of the mixers. Second, a simple and cost-effective method was exploited to fabricate the convoluted structure of the micromixers through the removal of a 3D-printed wax structure from a block of cured polydimethylsiloxane. Finally, the fabricated mixers with different threads were tested using a fluorescent microscope demonstrating a good agreement with the results of the numerical simulation. We envisage that the strategy used in this work would expand the scope of the micromixer technology by broadening the range of efficient working flow rate and providing an easy way to the fabrication of 3D convoluted microstructures. Published by AIP Publishing.

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Parametric study on mixing of two fluids in a three-dimensional serpentine microchannel

Cited by 89 publications

References 11 publications

A Review on Mixing in Microfluidics

A Review on Mixing in Microfluidics

Density-induced asymmetric pair of Dean vortices and its effects on mass transfer in a curved microchannel with two-layer laminar stream

An easily fabricated three-dimensional threaded lemniscate-shaped micromixer for a wide range of flow rates

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