The chapter explores the integration of nanotechnology, energy harvesting, and smart highways into global transportation infrastructure, aiming to create sustainable and efficient systems. Nanotechnology enhances road surface durability and functionality, offering increased strength, resilience, and self-healing properties. Energy harvesting techniques, such as piezoelectric and solar technologies, harness kinetic and solar energy from vehicular motion and sunlight, powering infrastructure, streetlights, and even the grid. Smart highways, enabled by interconnected sensors and communication systems, monitor traffic flow, adjust speed limits, provide real-time updates, and autonomously manage transportation systems. These innovations not only promise a sustainable transportation ecosystem but also catalyze economic growth, environmental preservation, and enhanced quality of life for communities worldwide.