Parametric Imaging of P-Glycoprotein Function at the Blood–Brain Barrier Using kE,brain-maps Generated from [11C]Metoclopramide PET Data in Rats, Nonhuman Primates and Humans
Louise Breuil,
Myriam El Biali,
Dominique Vodovar
et al.
Abstract:PET imaging using [ 11 C]metoclopramide revealed the importance of P-glycoprotein (P-gp, ABCB1) in mediating the brain-to-blood e ux of substrates across the blood-brain barrier (BBB). In this work, the elimination rate constant from the brain (k E,brain ), calculated from dynamic PET images without the need for arterial blood sampling, was evaluated as an outcome parameter for the interpretation of [ 11 C]metoclopramide PET data.Procedures: k E,brain parameter was obtained by linear regression of log-transfor… Show more
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