Parametric design, fabrication and validation of one-way polymeric valves for artificial sphincters

Mazzocchi, Tommaso; Ricotti, Leonardo; Pinzi, Novello; Menciassi, Arianna

doi:10.1016/j.sna.2015.07.005

Cited by 12 publications

(5 citation statements)

References 25 publications

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“…Nanostructured DLC, MoS 2 , and WS 2 were successfully deposited on PDMS substrates (Figure ). PDMS was selected as a general-purpose substrate for (i) its wide employment in the field of urinary devices, − (ii) its chemical inertia and excellent biocompatibility, (iii) its ability to be easily manufactured in a wide variety of shapes and to be tuned in terms of mechanical properties (Young’s modulus between few tens of kPa and few MPa) . All these properties guarantee an optimal interaction with the surrounding body tissues and a great potential toward the development of a wide class of medical devices.…”

Section: Resultsmentioning

confidence: 99%

Novel Nanostructured Coating on PDMS Substrates Featuring High Resistance to Urine

Cardona

Iacovacci

Mazzocchi

et al. 2018

ACS Appl. Bio Mater.

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Artificial urinary devices are commonly employed to restore the lost functionalities of the urinary system, due to diseases, disfunctions or organ resections. However, the long-term operation of these devices in the urinary system is affected by encrustations. In this paper, three different nanostructured coatings, based on diamondlike carbon (DLC), molybdenum disulfide (MoS2) and Tungsten disulfide (WS2), were deposited on polydimethylsiloxane substrates, an elastomer suitable for coating different kinds of urinary devices, and tested in terms of resistance to urinary encrustations. DLC coatings were deposited using plasma enhanced-chemical vapor deposition (T < 180 °C), whereas MoS2 and WS2 coatings were achieved through self-assembly at room temperature. All coatings showed good adhesion and stability on PDMS substrate over one month, relatively small roughness, a strongly hydrophobic behavior, and low surface energy. After immersion in artificial urine formulations and continuous mechanical agitation for 4 weeks, WS2 coating resulted the most resistant to encrustations. This material had been never investigated in the urinary context. Our results pave the way to the adoption of WS2 coatings for developing long-lasting stable urinary devices.

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Section: Resultsmentioning

confidence: 99%

Novel Nanostructured Coating on PDMS Substrates Featuring High Resistance to Urine

Cardona

Iacovacci

Mazzocchi

et al. 2018

ACS Appl. Bio Mater.

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“…AUS are a better treatment for severe SUI, they are prosthetic methods implanted surgically or endoscopically in the periurethral or urethral lumen, respectively, capable of replacing the function of the biological sphincter. 37,67 However, the implantation of AUS for the treatment of patients with urinary incontinence is commonly associated with postoperative complications, such as urethral atrophy, mechanical failure, and urethral infection. This means that existing solutions need to be improved by restoring abstinence in a safe and effective manner.…”

Section: Magnetically Controlled Aus Based On Novel Activationmentioning

confidence: 99%

Magnetically controlled artificial urinary sphincter: An overview from existing devices to future developments

et al. 2023

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Background Urinary incontinence is a common clinical problem in the world today. Artificial urinary sphincter is a good treatment approach for severe urinary incontinence, which is designed to mimic the action of the human urinary sphincter and assist patients to regain urinary function. Methods There are many control methods based on artificial urinary sphincter, such as hydraulic control, electromechanical control, magnetic control, and shape memory alloy control. In this paper, the literature was first searched and documented based on PRISMA search strategy for selected specific subject terms. Then, a comparison of artificial urethral sphincters based on different control methods was conducted, and the research progress of magnetically controlled artificial urethral sphincters was reviewed, and their advantages and disadvantages were summarized. Finally, the design factors for the clinical application of magnetically controlled artificial urinary sphincter are discussed. Results As magnetic control allows for non‐contact force transfer and does not generate heat, it is proposed that magnetic control may be one of the more promising control methods. The design of future magnetically controlled artificial urinary sphincters will need a variety of considerations, including the structural design of the device, manufacturing materials, manufacturing costs, and convenience. In addition, validation of the safety and effectiveness of the device and device management are equally important. Conclusions The design of an ideal magnetically controlled artificial urinary sphincter is of great importance to enhance patient treatment outcomes. However, there are still great challenges to be faced for the clinical application of such devices.

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“…The authors of [97] discussed design considerations related to actuation pressure minimization, reliability and convenient integration into complex microfluidic devices of such (normally closed) elastomeric valves. The concept of incised PDMS membranes has recently been developed further by [98] for the design and fabrication of artificial sphincters made of elastomeric polymers. Although intended for biomedical applications (the aim was to tackle urinary incontinence), the concept may also have potential in microfluidic structures.…”

Section: Microstructures Based On Pdmsmentioning

confidence: 99%

Stimulus-active polymer actuators for next-generation microfluidic devices

Hilber

2016

Appl. Phys. A

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Microfluidic devices have not yet evolved into commercial off-the-shelf products. Although highly integrated microfluidic structures, also known as lab-on-a-chip (LOC) and micrototal-analysis-system (lTAS) devices, have consistently been predicted to revolutionize biomedical assays and chemical synthesis, they have not entered the market as expected. Studies have identified a lack of standardization and integration as the main obstacles to commercial breakthrough. Soft microfluidics, the utilization of a broad spectrum of soft materials (i.e., polymers) for realization of microfluidic components, will make a significant contribution to the proclaimed growth of the LOC market. Recent advances in polymer science developing novel stimulus-active soft-matter materials may further increase the popularity and spreading of soft microfluidics. Stimulus-active polymers and composite materials change shape or exert mechanical force on surrounding fluids in response to electric, magnetic, light, thermal, or water/solvent stimuli. Specifically devised actuators based on these materials may have the potential to facilitate integration significantly and hence increase the operational advantage for the end-user while retaining costeffectiveness and ease of fabrication. This review gives an overview of available actuation concepts that are based on functional polymers and points out promising concepts and trends that may have the potential to promote the commercial success of microfluidics.

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Parametric design, fabrication and validation of one-way polymeric valves for artificial sphincters

Cited by 12 publications

References 25 publications

Novel Nanostructured Coating on PDMS Substrates Featuring High Resistance to Urine

Novel Nanostructured Coating on PDMS Substrates Featuring High Resistance to Urine

Magnetically controlled artificial urinary sphincter: An overview from existing devices to future developments

Stimulus-active polymer actuators for next-generation microfluidic devices

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