Parameters of Oxidative Stress in Colon Cancer Tissue

Veljković, Andrej; Stanojević, Goran; Branković, Branko; Pavlović, D.; Stojanović, Ivana; Cvetković, Tatjana; Jevtovic, T.; Sokolović, Dušan; Bašić, Jelena; Despotović, Milena; Đorđević, Biljana; Kocić, Gordana

doi:10.5633/amm.2016.0305

Cited by 11 publications

(10 citation statements)

References 25 publications

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“…Previous studies showed higher levels of AOPP in patients with cancers compared to healthy controls [ 54 , 66 , 68 , 76 ]. Veljković et al's study showed that the level of AOPP in the tumor tissue was significantly higher in comparison to the healthy colon tissue [ 77 ].…”

Section: Discussionmentioning

confidence: 99%

Improvement in Redox Homeostasis after Cytoreductive Surgery in Colorectal Adenocarcinoma

Salehi

Mirmiranpour

Rabizadeh

et al. 2021

Oxidative Medicine and Cellular Longevity

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Colorectal cancer (CRC) as one the most common cancer type is associated with oxidative stress. Surgery is the only curative modality for early-stage CRC. The aim of this study was to evaluate the oxidative damage biomarkers as well as enzymatic and nonenzymatic antioxidants in patients with CRC before and after tumor resection and in healthy controls. 60 patients with stage I/II colorectal adenocarcinoma and 43 healthy controls were recruited in this study. We measured plasma levels of oxidative damage biomarkers, including advanced oxidation protein products (AOPP), advanced glycation end products (AGEs), malondialdehyde (MDA), and oxidized low-density lipoprotein (ox-LDL) at baseline and after tumor removal. We also evaluated the plasma activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) as enzymatic antioxidants and the ferric reducing antioxidant power (FRAP) assay for nonenzymatic antioxidant capacity. Patients with CRC had significantly higher AGE, AOPP, MDA, and ox-LDL and also FRAP levels and higher SOD and GPx and lower CAT activity levels compared to healthy controls ( p < 0.05 ). We did not observe any statistically significant correlation between redox biomarkers and the size and stage of the tumor. AGEs ( 72.49 ± 4.7 vs. 67.93 ± 8.8 , p < 0.001 ), AOPP ( 137.64 ± 21.9 vs. 119.08 ± 33.1 , p < 0.001 ), MDA ( 3.56 ± 0.30 vs. 3.05 ± 0.33 , p < 0.001 ), and ox-LDL ( 19.78 ± 0.97 vs. 16.94 ± 1.02 , p < 0.001 ) concentrations reduced significantly after tumor removal. The largest effect sizes were found in ox-LDL ( d = − 2.853 , 95% CI 2.50-3.19) and MDA ( d = − 1.617 , 95% CI 0.43-0.57). Serum FRAP levels ( 1097.5 ± 156.7 vs. 1239.3 ± 290 , p < 0.001 ) and CAT ( 2.34 ± 0.34 vs. 2.63 ± 0.38 , p < 0.001 ), GPx ( 102.37 ± 6.58 vs. 108.03 ± 6.95 , p < 0.001 ), and SOD ( 5.13 ± 0.39 vs. 5.53 ± 0.31 , p < 0.001 ) activity levels increased significantly after surgery. The largest effect sizes among antioxidants were seen in SOD ( d = 1.135 , 95% CI 0.46-0.34) and GPx ( d = 0.836 , 95% CI 0.35-0.23). This study indicated that patients with colorectal cancer had higher levels of oxidative stress and antioxidant activity compared to healthy controls. After surgical resection of tumor, we observed a substantial improvement in redox homeostasis.

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Section: Discussionmentioning

confidence: 99%

Improvement in Redox Homeostasis after Cytoreductive Surgery in Colorectal Adenocarcinoma

Salehi

Mirmiranpour

Rabizadeh

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…The findings obtained thus far suggest that more intense oxidative stress and lower antioxidant protection mechanisms may play a significant role in the pathogenesis of CRC. Various authors have observed an increase in the MDA level in CRC patients compared with controls [16][17][18][19]. Only a few studies conducted so far present a detailed assessment of the intensity of lipid peroxidation processes in CRC patients depending on the co-occurrence of metabolic diseases, clinical stage of cancer or primary tumor location.…”

Section: Discussionmentioning

confidence: 99%

Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary Research

et al. 2020

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Background and objectives: Ample evidence indicates that oxidative stress, including complex lipid peroxidation processes, may play a significant role in the pathogenesis of colorectal cancer. The goal of this study was to evaluate selected oxidative stress markers in patients with colorectal cancer depending on some clinical features, with particular attention paid to the location of the primary tumor. Materials and Methods: The study was conducted on a group of 66 patients with colorectal cancer. The study consisted of two stages. The first stage involved the analysis of medical records; the second consisted of determining selected oxidative stress markers by measuring malondialdehyde as well as total oxidant and antioxidant status. Results: Of all patients, 43 (65.15%) had colon cancer, of whom 30 (69.77%) had a tumor on the left side and 13 (30.23%) had a tumor on the right side of the colon. Of all the patients, 23 (34.85%) had rectal cancer. The mean total oxidant and antioxidant status was 809.76 (SD ± 392.65) µmol/L and 253.19 (233.33–310.66) µmol/L, respectively. The mean malondialdehyde serum level was 2478.04 (SD ± 1397.05) ng/mL. The mean malondialdehyde serum concentration in patients with primary tumors located on the right side was higher in a statistically significant way compared with the remaining patients. Conclusions: It was demonstrated that the intensity of lipid peroxidation processes is correlated with the development of colorectal cancer, particularly on the right side. The results should be interpreted rather cautiously due to certain limitations of the study.

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“…In parallel, CAT activity significantly decreased in CRC patients BT compared to controls. In addition, it was shown that during CRC development, the activity of CAT decreased (8).…”

Section: Discussionmentioning

confidence: 99%

“…Surgery, combined with chemotherapy and/or radiotherapy, is the main CRC therapy strategy, which is efficient in the early stage of CRC; however, it is poorly efficient in the advanced stage of CRC with metastasis (6). There are several pathological factors, including reactive oxygen species (ROS), which are known to be mitogenic, capable of tumor promotion (7)(8)(9)(10), and involved in the process of cancer initiation and progression (11)(12)(13)(14)(15). Note that, hypermethylation of the gene promoter regions and oxidative damage to nuclear DNA are the main mechanisms in the initial stages of colorectal carcinogenesis (10,11).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Blood Antioxidant Defense and Oxidative Stress in Colorectal Carcinoma Patients Undergoing Capecitabine and Oxaliplatin Combined with Bevacizumab Treatment

Badid¹,

Merzouk²,

Charef³

2021

Electron. Physician

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Parameters of Oxidative Stress in Colon Cancer Tissue

Cited by 11 publications

References 25 publications

Improvement in Redox Homeostasis after Cytoreductive Surgery in Colorectal Adenocarcinoma

Improvement in Redox Homeostasis after Cytoreductive Surgery in Colorectal Adenocarcinoma

Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary Research

Assessment of Blood Antioxidant Defense and Oxidative Stress in Colorectal Carcinoma Patients Undergoing Capecitabine and Oxaliplatin Combined with Bevacizumab Treatment

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