Parameters of oxidative stress in saliva from diabetic and parenteral drug addict patients

Arana, Carlos; Cutando, Antonio; Ferrera, María José; Gómez‐Moreno, Gerardo; Worf, Cecilia Vander; Bolaños, Manuel Jorge; Escames, Germaine; Acuña-Castroviejo, Darı́o

doi:10.1111/j.1600-0714.2006.00469.x

Cited by 69 publications

(54 citation statements)

References 49 publications

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“…On the other hand, decreased antioxidant levels and/or increased production of reactive metabolites can lead to the destruction of homeostasis and drive the ox-idative damage [3,16]. Oxidative/nitrosative stress can seriously influence the cell viability and induce cellular responses leading to cell death [7].…”

Section: Introductionmentioning

confidence: 99%

Salivary Markers of Oxidative Stress and Antioxidant Status: Influence of External Factors

2013

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Abstract.BACKGROUND: Salivary markers of oxidative stress and antioxidant status represent promising tool for the research of oral diseases. One of the criteria is the validation of these biomarkers from the perspective of the confounding and modifying factors. AIM: To examine the effect of circadian rhythm, tooth-brushing and ascorbic acid treatment on selected salivary markers of oxidative and carbonyl stress, and antioxidant status. SUBJECTS AND METHODS: Whole unstimulated saliva samples were collected from 19 healthy participants three times during a day, before and after tooth-brushing, and before and after the administration of vitamin C (250 mg). Advanced oxidation protein products (AOPP), thiobarbituric acid reactive substances (TBARS), advanced glycation end products (AGEs), ferric reducing antioxidant power (FRAP) and total antioxidant capacity (TAC) were measured. RESULTS: Salivary AGEs levels varied significantly during the day (p < 0.05) with the highest concentrations in the morning. FRAP levels varied during the day (p < 0.01) with the highest concentrations in the afternoon. Tooth-brushing decreased AGEs (p < 0.05) and TBARS levels (p < 0.01) and increased FRAP levels (p < 0.05). Single intake of vitamin C significantly decreased AGEs (p < 0.001) and increased both FRAP (p < 0.01) and TAC (p < 0.01) concentrations. CONCLUSION: Significant daily variations were observed in salivary AGEs and FRAP levels. Tooth-brushing and treatment with vitamin C decreased carbonyl stress and increased the antioxidant status. These results are important from the perspective of using saliva for the research of oral diseases.

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Section: Introductionmentioning

confidence: 99%

Salivary Markers of Oxidative Stress and Antioxidant Status: Influence of External Factors

2013

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“…On the other hand, decreased antioxidant levels and/or increased production of reactive metabolites may disrupt homeostatic processes and lead to oxidative damage (1,2). Oxidative/nitrosative stress may have a serious impact on cell viability and induce cellular responses leading to cell death (3).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of salivary oxidative parameters in overweight and obese young adults

Chielle

Casarin

2017

Arch. Endocrinol. Metab.

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Background: Obesity is characterized by a deposition of abnormal or excessive fat in adipose tissue, and is linked with a risk of damage to several metabolic and pathological processes associated with oxidative stress. To date, salivary oxidative biomarkers have been minimally explored in obese individuals. Thus, the aim of this study was to assess the concentrations of salivary oxidative biomarkers (ferric-reducing antioxidant power, uric acid, sulfhydryl groups) and lipid peroxidation in obese and overweight young subjects. Materials and methods: Levels of lipid peroxidation, ferricreducing antioxidant power, uric acid, and SH groups were determined in the saliva and serum of 149 young adults, including 54 normal weight, 27 overweight, and 68 obese individuals. Anthropometric measurements were also evaluated. Results: Salivary levels of ferric-reducing antioxidant power, sulfhydryl groups, and lipid peroxidation, as well as serum levels of ferric-reducing antioxidant power, uric acid, and lipid peroxidation were higher in obese patients when compared with individuals with normal weight. There were correlations between salivary and serum ferric-reducing antioxidant power and salivary and serum uric acid in the obese and normal-weight groups. Conclusions: Our results indicate that the increase in salivary levels of ferric-reducing antioxidant power, sulfhydryl groups, and lipid peroxidation, and serum levels of ferric-reducing antioxidant power, uric acid, and lipid peroxidation could be related to the regulation of various processes in the adipose tissue. These findings may hold promise in identifying new oxidative markers to assist in diagnosing and monitoring overweight and obese patients. Arch Endocrinol Metab. 2017;61(2):152-9.

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“…Blood GSH was significantly decreased in different phases of type 2 diabetes mellitus such as: glucose intolerance and early hyperglycemia (20) and poor glycemic control (21) Measurement of salivary GPX and GRD activities and GSSG/GSH ratio, provide a noninvasive method to assess the degree of oxidative stress in pathophysiologic status, such as diabetes (22).…”

Section: Alteration In Glutathione Metabolismmentioning

confidence: 99%

Diabetes, Oxidative Stress, Antioxidants and Saliva: A Review

Al‐Rawi¹

2012

Oxidative Stress and Diseases

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Parameters of oxidative stress in saliva from diabetic and parenteral drug addict patients

Abstract: Changes in the antioxidant enzymes and glutathione levels in saliva from two different pathologic situations as those here studied suggest that this biologic fluid may be suitable for determining the prognosis and evolution of these diseases and its oral manifestations.

Cited by 69 publications

References 49 publications

Salivary Markers of Oxidative Stress and Antioxidant Status: Influence of External Factors

Salivary Markers of Oxidative Stress and Antioxidant Status: Influence of External Factors

Evaluation of salivary oxidative parameters in overweight and obese young adults

Diabetes, Oxidative Stress, Antioxidants and Saliva: A Review

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