Parameters of Oxidative and Inflammatory Status in a Three-Month Observation of Patients with Acute Myocardial Infarction Undergoing Coronary Angioplasty—A Preliminary Study

Abstract

Background and Objectives: Patients with acute myocardial infarction (MI) are usually treated with percutaneous transluminal coronary angioplasty (PTCA), which is burdened with a risk of postoperative complications, often accompanied by biochemical disturbances. The aim of our study was to evaluate a set of selected parameters of oxidative and inflammatory status, which could be useful in the management of post-procedural care in MI patients after PTCA. Materials and Methods: In this preliminary study, ischemia modified albumin (IMA), advanced oxidation protein products (AOPP), thiol groups (SH), total antioxidant status (TAS), insulin growth factor-1 (IGF-1), presepsin (PSP), and trimethylamine N-oxide (TMAO) were chosen as candidate biomarkers, and were determined in patients with MI who underwent PTCA at two time points: During cardiac episodes (at admission to the hospital, T0) and 3 months later (T3). Results: Most of the examined parameters were significantly different between patients and control subjects (except for IMA and TAS), but only hsCRP changed significantly during the time of observation (T0 vs. T3). Discriminant analysis created a model composed of AOPP, hsCRP, PSP, and TMAO, which differentiated male subjects into a group with MI and a control (without cardiovascular diseases). Conclusion: This set of parameters seems useful in evaluating inflammatory and oxidative status in MI patients after PTCA.

Sex-specific differences in trimethylamine N-oxide (TMAO) concentrations before and after cardiac rehabilitation in acute myocardial infarction patients

“…To the best of our knowledge, this is the first study addressing possible sex-specific differences in individuals after AMI. In comparison, two previously published studies that reported TMAO as a possible predictive parameter of biochemical and cardiovascular status after AMI unfortunately did not consider sex-specific influences on this biomarker (Żurawska-Płaksej et al, 2019[ 29 ]; Matsuzawa et al, 2019[ 15 ]).…”

“…Recently, microbiota-derived pro-atherogenic TMAO was also shown to be a useful parameter in the management of the post-procedural care of patients with AMI (Żurawska-Płaksej, et al, 2019[ 29 ]). Serum TMAO levels after AMI were associated with coronary plaque complexity and progression and significantly predicted future cardiovascular events in AMI patients (Matsuzawa et al, 2019[ 15 ]).…”

All-Cause Mortality and Trimethylamine N-Oxide Levels in Patients with Cardiovascular Disease

“…A simple and rapid method of liquid chromatography with tandem mass spectrometry was used to determine TMAO levels in the serum [17]. Samples were extracted by adding d9-TMAO (Cambridge Isotope Laboratories, Tewksbury, MA, USA) to acetonitrile:methanol 1:1 (vol/vol) mixture at a ratio of 1:4.…”

Testing for Ketoprofen Binding to HSA Coated Magnetic Nanoparticles under Normal Conditions and after Oxidative Stress

“…The effect of ROS action on body components such as proteins is called oxidative stress. It accompanies many diseases related to inflammation, autoimmune response, invasive surgery, or even during intensive exercise [4][5][6]. HSA can be modified by the action of oxidative stress at various places in the structure and by different ROS.…”