Parameters of Heart Rate Variability Can Predict Prolonged Asystole before Head‐Up Tilt Table Test

Gursul, Erdal; Bayata, Serdar; Tülüce, Selcen Yakar; Berilgen, Rida; Şafak, Özgen; Özdemir, Emre; Tülüce, Kamil

doi:10.1111/anec.12149

Cited by 7 publications

(4 citation statements)

References 23 publications

(21 reference statements)

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“…The differences in RMSSD values observed between LH (42.7 ± 21.8 ms) and RH (46.4 ± 22.6 ms) in the present study, although trending in the same direction, were not statistically significant ( p = 0.156). SDNN and RMSSD can effectively serve as interchangeable proxies for each other ( 26 ); however, disparate findings between SDNN and RMSSD have also previously been reported ( 27 , 28 ). Importantly, RMSSD was lower in LH compared to RH, which is indicative of a greater autonomic nervous system dysfunction ( 11 ) and represents an increase in CVD risk.…”

Section: Discussionmentioning

confidence: 99%

Evidence of increased cardiovascular disease risk in left-handed individuals

Simon,

Norland,

Blackburn

et al. 2023

Front. Cardiovasc. Med.

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BackgroundApproximately 10% of the world is left-handed (LH). Research suggests that LH individuals may have shorter lifespans compared to right-handed (RH) individuals. LH individuals also appear to have more cardiovascular disease (CVD) related conditions like diabetes and cancer. Thus, the present study sought to test the hypothesis that vascular function and heart rate variability (HRV), both key indicators of CVD risk, would be lower in LH compared to RH individuals.MethodsThree hundred seventy-nine participants, 18–50 years old, were enrolled. Flow-mediated dilation (FMD), a bioassay of vascular endothelial function and standard deviation of R-R interval (SDNN), a parameter of HRV, were evaluated as indices of CVD risk. Data are reported as mean ± SD.Results12.1% of the participants were LH. No differences in demographics or clinical laboratory values were observed between groups, except high-density lipoprotein (HDL) was higher (p = 0.033) in RH. FMD was significantly (p = 0.043) lower in LH (6.1% ± 3.2%) compared to RH (7.6% ± 3.8%), independent of age, sex, race, BMI, and HDL. Total power (p = 0.024) and low-frequency power (p = 0.003) were lower in LH compared to RH. Additionally, SDNN was lower (p = 0.041) in LH (47.4 ± 18.8 ms) compared to RH (54.7 ± 22.3 ms). A negative correlation between FMD and mean arterial pressure (r = −0.517; p < 0.001) was observed in LH; no relationships were observed in RH (all p > 0.05).ConclusionVascular endothelial function and HRV are lower in LH compared to RH. In addition, relationships between FMD and traditional CVD risk factors were only observed in LH. These data support an increased risk of CVD in LH.

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Section: Discussionmentioning

confidence: 99%

Evidence of increased cardiovascular disease risk in left-handed individuals

Simon,

Norland,

Blackburn

et al. 2023

Front. Cardiovasc. Med.

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“…Following an orthostatic challenge, the migration of blood from the thorax to the lower extremities reduces venous return and subsequently stroke volume (Moya et al, 2009), thus leading to decreased vagal tone and increased sympathetic nerve activity (Montano et al, 1994). The HRV responses to an orthostatic challenge have previously been utilized to investigate the influence of various clinical and environmental conditions on sympatho-vagal balance, including vasovagal syncope in adults (Guzman et al, 1999;Gursul et al, 2014) and children (Moak et al, 2002;Evrengul et al, 2006), orthostatic hypotension (Sato et al, 2007;Lu et al, 2014), temporal lobe epilepsy (Ansakorpi et al, 2011), Parkinson's disease (Mihci et al, 2006;Haensch et al, 2009), hyperthyroidism (Tobaldini et al, 2008), chronic fatigue syndrome (Yamamoto et al, 2003), spinal cord injury (Iellamo et al, 2001), complex regional pain syndrome (Terkelsen et al, 2012), eating disorders (Murialdo et al, 2007), mental stress (Hynynen et al, 2011) and space flight (Blaber et al, 2004). While not directly comparable owing to differences in protocol, signal acquisition and analytical techniques, the 15% reduction in RMSDD and 20% reduction in HF following the orthostatic challenge in the current study is in line with the 27-83% reduction in RMSDD (Carrasco et al, 2003;Gil et al, 2010;Young & Leicht, 2011;Terkelsen et al, 2012) and a 10-87% reduction in HF (Iellamo et al, 2001;Carrasco et al, 2003;Ansakorpi et al, 2011;Hynynen et al, 2011;Young & Leicht, 2011;Terkelsen et al, 2012) reported for control groups used in the previously referenced studies.…”

Section: Validitymentioning

confidence: 99%

Telemetry‐derived heart rate variability responses to a physical stressor

Montano

Brown

Credeur

et al. 2016

Clin Physio Funct Imaging

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“…[ 12 13 14 ] To diagnose neurally mediated syncope, head-up tilt testing is used and to evaluate autonomic nervous activity in cardiovascular disease, frequency-domain analysis of electrocardiographic RR variations is performed. [ 15 16 17 18 19 ] This study aims to evaluate the effect of RFCA on autonomic system in patients with PSVT by head-up tilt table (HUTT) test.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effect of radiofrequency catheter ablation on autonomic function in patients with atrioventricular nodal reentrant tachycardia by head-up tilt table test

et al. 2015

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Background:One of the recommended treatments for atrioventricular nodal reentrant tachycardia (AVNRT), is radiofrequency catheter ablation (RFCA). However, RFCA may affect the autonomic system. This study aims to evaluate the effect of RFCA on autonomic system in patients with PSVT by head-up tilt table (HUTT) test.Materials and Methods:In a before–after study, 22 patients with PSVT were enrolled. Data were collected with a data collection form that included two parts. Electrocardiogram (ECG), echocardiogram, 24-h Holter monitoring, HUTT test, heart rate variability (HRV) indexes, and symptoms of all patients were recorded 24 h before and 1 month after the ablation. Wilcoxon, McNemar, Mann–Whitney U, and Chi-square tests were used to analyze the data.Results:Of the total 22 patients, 31.8% were male and 68.2% were female. There were significant differences in heart palpitation (P < 0.0001) and non-specific symptoms (P = 0.031) and no significant difference in head-up tilt test results and HRV indices before and after RFCA. The results showed that there were no significant differences in specific and non-specific symptoms in patients with AVNRT with positive and negative HUTT before and after RFCA.Conclusions:The observed difference in heart palpitation and non-specific symptoms emphasized the role of AVNRT in causing these symptoms. Autonomic dysfunction is more probably an accompanying condition of AVNRT than causing symptoms. We could not find any significance in the results of HUTT after RFCA. HUTT cannot determine or predict the symptoms after RFCA.

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Parameters of Heart Rate Variability Can Predict Prolonged Asystole before Head‐Up Tilt Table Test

Cited by 7 publications

References 23 publications

Evidence of increased cardiovascular disease risk in left-handed individuals

Evidence of increased cardiovascular disease risk in left-handed individuals

Telemetry‐derived heart rate variability responses to a physical stressor

Evaluation of the effect of radiofrequency catheter ablation on autonomic function in patients with atrioventricular nodal reentrant tachycardia by head-up tilt table test

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