Parameters influencing the stealthiness of colloidal drug delivery systems

Vonarbourg, Arnaud; Passirani, Catherine; Saulnier, Patrick; Benoit, Jean‐Pierre

doi:10.1016/j.biomaterials.2006.03.039

Cited by 664 publications

(511 citation statements)

References 162 publications

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“…In this context, biotin would offer a wide array of possibilities, allowing not only a selective targeting to different kinds of cancerous cells but also an increase of cellular internalization of NPs and a depletion of the reticuloendothelial system uptake [27]. The successful incorporation and integrity of the biotin in PUR NPs was corroborated by fluorescence confocal microscopy after incubating NPs with Atto 565 streptavidin complex (Fig.…”

Section: In the Electronic Supplementary Materials (Esm))mentioning

confidence: 85%

Biotinylated polyurethane-urea nanoparticles for targeted theranostics in human hepatocellular carcinoma

et al. 2015

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Over the past years, significant efforts have been devoted to explore novel drug delivery and detection strategies for simultaneous therapy and diagnostics. The development of biotinylated polyurethane-urea nanoparticles as theranostic nanocarriers for targeted drug and plasmid delivery, for fluorescence detection of human hepatocellular carcinoma cells, is described herein. These targeted nanoparticles are specifically designed to incorporate biotin into the polymeric matrix, since many tumor types overexpress receptors for biotin as a mechanism to boost uncontrolled cell growth. The obtained nanoparticles were spherical, exhibited an average diameter ranging 110-145 nm, and showed no cytotoxicity in healthy endothelial cells. Biotinylated nanoparticles are selectively incorporated into the perinuclear and nuclear area of the human hepatocellular carcinoma cell line, HepG2, in division, but not into growing, healthy, human endothelial cells. Indeed, the simultaneous incorporation of the anticancer drugs, phenoxodiol or sunitinib, together with plasmid DNA encoding green fluorescent protein, into these nanoparticles allows a targeted pharmacological antitumor effect and furthermore, selective transfection of a reporter gene, to detect these cancer cells. The combined targeted therapy and detection strategy described here could be exploited for liver cancer therapy and diagnostics, with a moderate safety profile, and may also be a potential tool for other types of cancer.

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Section: In the Electronic Supplementary Materials (Esm))mentioning

confidence: 85%

Biotinylated polyurethane-urea nanoparticles for targeted theranostics in human hepatocellular carcinoma

et al. 2015

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“…32 Various parameters, such as the nature of the components, the size, apparent electrical charge, and hydrophilicity of the carriers, influenced the elimination of such colloidal systems. 33 Coating with hydrophilic polymer chains (PEG and its derivatives) to the surface of the colloidal carriers afforded them a highly hydrophilic shield away from electrostatic and hydrophobic interactions with serum components as well as reduced uptake by MPS. 34 In comparison to conventional nanocarriers without PEG modification, these PEGylated colloidal drug delivery systems showed a prolonged retention time in blood, primarily due to the reduced recognition and uptake by phagocytic cells of the MPS located mainly in the liver and spleen.…”

Section: Pharmacokinetics Of Lbt-oa-ne and Lbt-oa-peg-ne In Ratsmentioning

confidence: 99%

Nanoemulsion loaded with lycobetaine–oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity

Zhao¹,

Lü²,

Gong³

et al. 2013

IJN

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Background: Intravenous injection of lycobetaine was found to show significant cytotoxic activity against (inter alia) Lewis lung carcinoma, but its therapeutic use is largely limited due to an extremely short half-life in blood. This study aimed at developing a novel lipid nanocarrierbased formulation for lycobetaine delivery. The formulation is feasible for scale-up production, exhibiting good parenteral acceptability and improved circulation characteristics. Methods: To enhance its lipophilicity, oleic acid was selected to form ionic complexes with lycobetaine (LBT). The nanoemulsion loaded with LBT-oleic acid complex (LBT-OA-nanoemulsion) and PEGylated LBT-OA-nanoemulsion (NE) (LBT-OA-PEG-NE) were prepared by a simple high-pressure homogenization method. Results: A high-encapsulation efficiency of around 97.32% ± 2.09% was obtained for LBT-OA-PEG-NE under optimized conditions. Furthermore, the in vivo pharmacokinetics and biodistribution of LBT-OA-NE, LBT-OA-PEG-NE, and free LBT were studied in rats. Free LBT and LBT-OA-PEG-NE displayed AUC 0-10h (area under the concentration-time curve from 0 to 10 hours) of 112.99 mg/L*minute and 3452.09 mg/L*minute via intravenous administration (P , 0.005), respectively. Moreover, LBT-OA-PEG-NE showed significantly lower LBT concentration in the heart, liver, and kidney, while achieving higher concentration of LBT in the lung when compared to free LBT at the same time (P , 0.005). The LBT-OA-PEG-NE exhibited higher growth inhibitory effect and longer survival time than free LBT in both heterotopic and lung metastatic tumor models. Conclusion: These results demonstrated that LBT-OA-PEG-NE is an attractive parenteral formulation for cancer therapy.

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“…The complement system is a family of blood proteins that become activated in the presence of foreign materials. They initiate a cascade that can result in opsonization, the adsorption of proteins on the surface, of nanoparticles, which marks them for uptake and clearance by the cells of the MPS [7,8,11,12]. Thus it is desirable for nanoparticles to maintain a surface that prevents opsonization of complement proteins and antibodies, which will prolong the particles circulation time.…”

Section: Immune System and Clearance Routesmentioning

confidence: 99%

“…Previously, it has been found that hydrophobic and highly charged surfaces are the most prone to opsonization, while hydrophilic and neutral surfaces are not, and are thus more "stealthy" [10,11,13]. Furthermore, particle size has been found to play a role as well, with larger particles experiencing more rapid clearance than smaller particles [8,12]. However one must ensure that the particles are not too small, as materials less than 5.5 nm in hydrodynamic size tend to experience rapid clearance by the kidneys [14].…”

Section: Immune System and Clearance Routesmentioning

confidence: 99%

Nanotechnology and Diagnostic Imaging: New Advances in Contrast Agent Technology

Rosen¹,

Yoffe²,

Meerasa³

2011

J Nanomedic Nanotechnol

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Medical imaging technologies allow for the rapid diagnosis and evaluation of a wide range of pathologies. In order to increase their sensitivity and utility, many imaging technologies such as CT and MRI rely on intravenously administered contrast agents. While the current generation of contrast agents has enabled rapid diagnosis, they still suffer from many undesirable drawbacks including a lack of tissue specificity and systemic toxicity issues. Through advances made in nanotechnology and materials science, researchers are now creating a new generation of contrast agents that overcome many of these challenges, and are capable of providing more sensitive and specific information. In this review, we summarize the main classes of nanotechnology-based contrast agents for each of the major imaging technologies, and highlight progress in their development as well as the challenges to be addressed. We also review the relevant biological interactions that determine the in vivo fate of these contrast agents, and describe major themes in medical nanotechnology including stealth and targeting.

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Parameters influencing the stealthiness of colloidal drug delivery systems

Cited by 664 publications

References 162 publications

Biotinylated polyurethane-urea nanoparticles for targeted theranostics in human hepatocellular carcinoma

Biotinylated polyurethane-urea nanoparticles for targeted theranostics in human hepatocellular carcinoma

Nanoemulsion loaded with lycobetaine–oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity

Nanotechnology and Diagnostic Imaging: New Advances in Contrast Agent Technology

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Parameters influencing the stealthiness of colloidal drug delivery systems

Cited by 664 publications

References 162 publications

Biotinylated polyurethane-urea nanoparticles for targeted theranostics in human hepatocellular carcinoma

Biotinylated polyurethane-urea nanoparticles for targeted theranostics in human hepatocellular carcinoma

Nanoemulsion loaded with lycobetaine&ndash;oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity

Nanotechnology and Diagnostic Imaging: New Advances in Contrast Agent Technology

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Nanoemulsion loaded with lycobetaine–oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity