2002
DOI: 10.1046/j.1359-4117.2002.01007.x
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Parameters affecting the ex vivo cytotoxic drug sensitivity of human hematopoietic cells

Abstract: The drug sensitivity of normal cells provides a baseline for determining the therapeutic index, and therefore the effectiveness, of cytotoxic drugs, yet little is known about the factors that affect normal cell chemosensitivity. Some parameters are known to have a profound effect on tumor cell sensitivity. The purpose of this study was to determine how cytotoxic drug sensitivity of hematopoietic cells isolated from cancer patients was affected by various parameters. These included previous chemotherapy (yes or… Show more

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Cited by 8 publications
(7 citation statements)
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“…With regards to cancer treatment, most current anticancer regimes do not effectively differentiate between cancerous and normal cells. This indiscriminate action frequently leads to systemic toxicity and debilitating adverse effects in normal body tissues including bone marrow suppression, neurotoxicity, and cardiomyopathy [5,6]. Nanotechnology and nanomedicine can offer a more targeted approach which promises significant improvements in the treatment of cancer [5].…”
Section: Introductionmentioning
confidence: 99%
“…With regards to cancer treatment, most current anticancer regimes do not effectively differentiate between cancerous and normal cells. This indiscriminate action frequently leads to systemic toxicity and debilitating adverse effects in normal body tissues including bone marrow suppression, neurotoxicity, and cardiomyopathy [5,6]. Nanotechnology and nanomedicine can offer a more targeted approach which promises significant improvements in the treatment of cancer [5].…”
Section: Introductionmentioning
confidence: 99%
“…Cell lines differ from primary cells taken directly from the living tissue, in terms of growth kinetics and pharmacological determinants (e.g., sex, age, presence of mutations, etc.). [ 78 ] We obtained preliminary results on blasts from patients with acute myeloid leukemia (see Supporting Information Materials, Table S1 and Figure S1), where PAM induced a milder cytotoxic effect, compared with T‐leukemia Jurkat cells. A different cytotoxic effect of CAP on primary cells, compared with cell lines, was observed, for example, for prostate cancer.…”
Section: Discussionmentioning
confidence: 99%
“…Ex vivo samples represent a quite good surrogate for determining the cellular response of the patient to the treatment and predicting the clinical outcome [32][34]. This can not be realized by using cell lines, which markedly differ from blasts directly taken from leukemic patients in terms of growth kinetics and pharmacological determinants [35].…”
Section: Discussionmentioning
confidence: 99%