Increasing the wing aspect ratio appears as a straightforward way to improve aerodynamic performance of transport aircraft by reducing the lift-induced drag component. However, it comes at the price of a direct negative impact on the wing structural weight which is necessary to sustain aerodynamic loads in the case of a conventional cantilever wing. The strut-braced wing concept allows to reduce the flexural moment to be carried out by the inner-wing structure and therefore limits the weight penalty as aspect ratio is increased. A multidisciplinary evaluation of the potential benefits at aircraft level of High Aspect Ratio, Strut Braced Wing concept is presented. It relies on a multi-fidelity design approach in which an Overall Aircraft Conceptual Design framework is combined with high-fidelity aerodynamic and structural analyses to provide accurate physical information to the conceptual design process. This paper describes the tools, framework and approach used to combine OACD with high-fidelity CFD and CSM analyses and illustrates the first results of its application to design a HAR-SBW aircraft concept which are compared to a conventional tube-and-wing aircraft designed for the same mission.