Parameter Reproducibility in Photobiomodulation

Tunér, Jan; Jenkins, Peter

doi:10.1089/pho.2016.4105

Cited by 31 publications

(18 citation statements)

References 5 publications

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“…Unfortunately, the heterogeneity of laser parameters and the discordant, and in some cases unclear therapeutic procedures as well as the unspecified features of the probe, hand-piece, or fiber employed for laser administration, did not allow for an intergroup analysis of the studies. A major problem in PBM, as carefully reported by Tuner and Jenkins [ 84 ], is the lack of proper reporting of the parameters, which does not enable reproducibility of the experimental results. Previously, we showed [ 85 ] that fluence per se did not predict the photobimodulatory effect of laser light on the cell, but a precise relation exists between laser power and duration of exposure.it was found that ”the energy has two-component power and time of exposure, and it has been demonstrated that there is not necessarily reciprocity between them and expected effects.…”

Section: Discussionmentioning

confidence: 99%

Interaction between Laser Light and Osteoblasts: Photobiomodulation as a Trend in the Management of Socket Bone Preservation—A Review

Amaroli

Colombo

Zekiy

et al. 2020

Biology

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Bone defects are the main reason for aesthetic and functional disability, which negatively affect patient’s quality of life. Particularly, after tooth extraction, the bone of the alveolar process resorbs, limiting the optimal prosthetic implant placement. One of the major pathophysiological events in slowly- or non-healing tissues is a blood supply deficiency, followed by a significant decrease in cellular energy amount. The literature shows that photons at the red and infrared wavelengths can interact with specific photoacceptors located within the cell. Through this mechanism, photobiomodulation (PBM) can modify cellular metabolism, by increasing mitochondrial ATP production. Here, we present a review of the literature on the effect of PBM on bone healing, for the management of socket preservation. A search strategy was developed in line with the PRISMA statement. The PubMed and Scholar electronic databases were consulted to search for in vivo studies, with restrictions on the year (<50 years-old), language (English), bone socket preservation, and PBM. Following the search strategy, we identified 269 records, which became 14, after duplicates were removed and titles, abstract and inclusion-, exclusion-criteria were screened. Additional articles identified were 3. Therefore, 17 articles were included in the synthesis. We highlight the osteoblast–light interaction, and the in vivo therapeutic tool of PBM is discussed.

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Section: Discussionmentioning

confidence: 99%

Interaction between Laser Light and Osteoblasts: Photobiomodulation as a Trend in the Management of Socket Bone Preservation—A Review

Amaroli

Colombo

Zekiy

et al. 2020

Biology

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“…Unfortunately, many of the prior studies have failed to report relevant treatment parameters due to inadequate understanding of critical dose characteristics. Nonetheless, it is now strongly recommended that a comprehensive treatment variables be carefully assessed and fully reported .…”

Section: Discussionmentioning

confidence: 99%

Improved Wound Remodeling Correlates with Modulated TGF‐beta Expression in Skin Diabetic Wounds Following Combined Red and Infrared Photobiomodulation Treatments

Fekrazad

Sarrafzadeh

Kalhori

et al. 2018

Photochem & Photobiology

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Diabetic wounds are a major cause of morbidity among patients with poorly controlled blood glucose levels. Conventional empirical wound care strategies have shown limited efficacy, and there is an urgent need to develop novel therapeutic strategies. Photobiomodulation treatments have shown positive therapeutic effects in several cell culture and animal models. In this study, we examined wound healing in diabetic rats following treatments with two laser wavelengths, namely red (660 nm) and infrared (808 nm) individually and in combination as compared to routine wound dressings. Immunostaining for TGF-β expression was performed at various times postwounding. We noted that the combination of red and infrared laser treatments correlated with decreased TGF-β1 levels at late stages in healing. There was no statistical significance with any treatments at an earlier time point. This study emphasizes the role of appropriate laser treatment protocols in modulating wound healing and remodeling responses.

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“…In terms of the physical determinants of the light device, there is increased appreciation in the field of the device and dose delivery parameters (Arany, ; Jenkins & Carroll, ; Tuner & Jenkins, ). Among these, the use of a small spot size of laser results in various empirical scanning patterns clinically that are difficult to precisely reproduce.…”

Section: Photobiomodulation Therapy In Oral Diseasesmentioning

confidence: 99%

Learning from clinical phenotypes: Low‐dose biophotonics therapies in oral diseases

et al. 2018

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This narrative review on the use of biophotonics therapies for management of oral diseases is written as a tribute to Prof. Crispian Scully. His seminal contributions to the field are highlighted by the detailed, comprehensive description of clinical presentations of oral diseases. This has enabled a more thorough, fundamental understanding of many of these pathologies by research from his group as well as inspired mechanistic investigations in many groups globally. In the same vein, a major emphasis of this narrative review is to focus on the evidence from human case reports rather than in vitro or in vivo animal studies that showcases the growing and broad impact of biophotonics therapies. The similarities and differences between two distinct forms of low-dose biophotonics treatments namely photodynamic therapy and photobiomodulation therapy are discussed. As evident in this review, a majority of these reports provide promising evidence for their clinical efficacy. However, a lack of adequate technical details, precise biological rationale, and limited outcome measures limits the current utility of these treatments. Future investigations should attempt to address these shortcomings and develop better designed, rigorous, controlled studies to fully harness the tremendous potential of low-dose biophotonics therapies.

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Parameter Reproducibility in Photobiomodulation

Cited by 31 publications

References 5 publications

Interaction between Laser Light and Osteoblasts: Photobiomodulation as a Trend in the Management of Socket Bone Preservation—A Review

Interaction between Laser Light and Osteoblasts: Photobiomodulation as a Trend in the Management of Socket Bone Preservation—A Review

Improved Wound Remodeling Correlates with Modulated TGF‐beta Expression in Skin Diabetic Wounds Following Combined Red and Infrared Photobiomodulation Treatments

Learning from clinical phenotypes: Low‐dose biophotonics therapies in oral diseases

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