Social entrepreneurship has been a key tool to address the social and economic challenges of the COVID-19 pandemic. Social enterprises have played a critical role in creating innovative solutions to address the social and economic needs of affected communities. However, they have also faced significant challenges such as a lack of financial resources, the disruption of supply chains, and the need to quickly adapt to changing social and economic needs. In this context, it is necessary to analyze the opportunities and challenges facing social entrepreneurship during the pandemic. Opportunities include innovation, collaboration, and digitization, as well as financing and sustainability. To take advantage of these opportunities, social enterprises need to have strong strategic planning, a highly trained team, and a focus on impact measurement. On the other hand, challenges include lack of funding and government support, economic uncertainty, and resource constraints. To overcome these challenges, social enterprises must seek new sources of financing and collaboration with other actors in the entrepreneurial and government ecosystem. In short, social entrepreneurship in a pandemic face both challenges and opportunities. Despite the challenges, social enterprises can make a significant contribution to addressing the social and economic challenges of the pandemic and creating a positive impact in affected communities.