With the rapid development of society, the real estate economy, as an important part of Chinese economy, is showing a growing trend. But it is also the most likely to generate bubble economy, causing financial risks; it will trigger a series of social contradictions and cause social unrest in severe cases. Therefore, it is urgent to improve and optimize the real estate evaluation model. In this study, the real estate was evaluated based on the neural network model optimized by genetic algorithm. Through sorting out and summarizing the real estate data in a period of time, the corresponding model was established and the test data were obtained. The average relative error value of the genetic algorithm optimized neural network model was 3.552, which was smaller than that of the Back-Propagation (BP) neural network prediction model. The experimental conclusion that the new network model was better than the traditional model was obtained. This work opens up a new route of real estate evaluation.It was found from Figure 4 that with the increase of training times, the mean square error of the two models decreased, and the overall trend was downward. With the increase of training times, the accuracy was improved. However, under the same number of training, the mean square error of the optimal BP neural network obtained by the genetic neural network model was smaller than that obtained by the BP neural network model. Therefore, the accuracy of genetic neural network in real estate data evaluation was much higher than that of BP neural network. Moreover the convergence speed of the training of the genetic neural network model was much faster than that of the BP neural network model. The reason was that the genetic neural network model had screened out the most appropriate weights and thresholds, and the optimal BP neural network was obtained, which greatly improved the training convergence speed.It was found from Figure 5 that there was a large difference between the real price and the price evaluated by BP neural network model, the trend of them was different, and the overall fitting degree was low. The difference between the real estate price and the price evaluated by the genetic neural network was small, the trend of them was basically similar, and the overall fitting degree was high. Therefore, it was concluded that the genetic neural network model was more accurate for real estate evaluation data and had a higher overall fitting degree.