Paramagnetic CuS hollow nanoflowers for <i>T</i><sub>2</sub>-FLAIR magnetic resonance imaging-guided thermochemotherapy of cancer

Zhang, Hao; Chen, Yaodong; Cai, Yunyu; Liu, Jun; Liu, Pengfei; Li, Zizhuo; An, Tingting; Yang, Xiuhua; Liang, Changhao

doi:10.1039/c8bm01412d

Cited by 24 publications

(23 citation statements)

References 44 publications

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“…Increasing the temperature led to a CO 2 -enhanced ultrasound for attaining NIR thermal/PA/ultrasonic trimodal imaging. 67,68 Liang et al have utilized a modied glutathione (GSH) for developing GSH-Cu 2Àx S NPs. The contrast intensity of the photoacoustic signal depends on the concentration of the NPs.…”

Section: Copper Sulde Applications In Cancermentioning

confidence: 99%

Copper sulfide nanostructures: synthesis and biological applications

et al. 2022

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Section: Copper Sulde Applications In Cancermentioning

confidence: 99%

Copper sulfide nanostructures: synthesis and biological applications

et al. 2022

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“…Zhang et al fabricated hollow CuS nanoflower for MRI-guided DOX-loaded chemo/photothermal liver cancer therapy. 61 In their study, both T 1 -weighed MRI and T 2 -weighted fluid-attenuated inversion recovery (T 2 -FLAIR) MRI were effective for imaging in in vitro experiments. However, the latter technique was more robust than the former; therefore, T2-FLAIR MRI was utilised for subsequent in vivo experiments.…”

Section: Photothermal-based Therapy For Cancer Treatmentmentioning

confidence: 99%

Advances in Hollow Inorganic Nanomedicines for Photothermal-Based Therapies

Chen¹,

Wang²,

Shen³

2021

IJN

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Nanotechnology has prompted the development of hollow inorganic nanomedicine. These medicines are now widely investigated as photothermal-based therapies for various diseases due to their high loading capacity, tuneable wavelength, relatively small size and low density. We begin this review with a brief introduction, followed by a summary of the development of imaging-guided photothermal therapy (PTT) for cancer treatment during the last three years (from 2017 to 2020). We then introduce the antibacterial effects of these medicines on some bacterial infections, in which the pathogenic bacteria can be killed by mild photothermal effects, ions and antibiotic release. Other diseases can also be treated using hollow inorganic photothermal agents. Specifically, we discuss the use of PTT for treating Alzheimer's disease, obesity and endometriosis. Finally, we share our perspectives on the current challenges and future prospects of using hollow inorganic materials in clinical PTT for various diseases.

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“…5G). Noninvasive appraisal with clinical imaging technologies often provides detailed and accurate information to evaluate the therapeutic effect without increasing side effects and mortality (Fetzer et al, 2017;Zhang et al, 2018). USI, which is one of the most common imaging techniques in the clinical diagnosis of HCC, as well as for monitoring of the progression and therapeutic effect, was performed to assess the anti-HCC effects of CVB-D in HepG2 tumor-bearing mice.…”

Section: Cvb-d Inhibits Hcc Progression In Vivomentioning

confidence: 99%

Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma

Zhang

Chen

Lin

et al. 2020

DNA and Cell Biology

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Hepatocellular carcinoma (HCC), the sixth most common malignancy worldwide, is characterized by a dismal prognosis due to high recurrence and metastasis rates. Thus, the need for the development of novel chemotherapeutic drugs is urgent. Cyclovirobuxine D (CVB-D), a steroidal alkaloid extracted from Buxus microphylla that has been extensively used to relieve the symptoms of cardiovascular diseases, has shown promising antineoplastic effects in recent studies. However, the therapeutic effects and underlying mechanisms of CVB-D on HCC remain largely unelucidated. This study experimentally indicated that CVB-D can repress HCC cell proliferation by arresting the cell cycle in G2 phase and can facilitate apoptosis. In addition, the migratory and invasive capabilities of HCC cells were noticeably attenuated by a nonlethal dose of CVB-D, and this attenuation was correlated with the inhibition of epithelial-mesenchymal transition (EMT). Moreover, in vivo, CVB-D displayed excellent anticancer effects in HCC tumor-bearing nude mice. Regarding the molecular mechanisms of CVB-D activity, decreased Slug expression was determined to be associated with the aforementioned anti-HCC functions of this extract, which might be regulated by epidermal growth factor receptor (EGFR) through the focal adhesion kinase (FAK)-associated PI3K/AKT and MEK/ERK1/2 signaling pathways. Collectively, our results revealed the suppressive effects of CVB-D on progressive behaviors of HCC, including proliferation, migration, invasion, and EMT, in addition to its outstanding proapoptotic effects, which were correlated with the inhibition of the EGFR-FAK-AKT/ERK1/2-Slug signaling pathway. These discoveries provide an experimental and theoretical foundation for the use of CVB-D as a promising candidate for HCC therapy.

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Paramagnetic CuS hollow nanoflowers for T₂-FLAIR magnetic resonance imaging-guided thermochemotherapy of cancer

Abstract: Green synthesized 3D CuS hollow nanoflowers are for the first time proved to be a T1 positive MRI contrast agent for imaging-guided thermochemotherapy.

Cited by 24 publications

References 44 publications

Copper sulfide nanostructures: synthesis and biological applications

Copper sulfide nanostructures: synthesis and biological applications

Advances in Hollow Inorganic Nanomedicines for Photothermal-Based Therapies

Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma

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Paramagnetic CuS hollow nanoflowers for T2-FLAIR magnetic resonance imaging-guided thermochemotherapy of cancer

Abstract: Green synthesized 3D CuS hollow nanoflowers are for the first time proved to be a T1 positive MRI contrast agent for imaging-guided thermochemotherapy.

Cited by 24 publications

References 44 publications

Copper sulfide nanostructures: synthesis and biological applications

Copper sulfide nanostructures: synthesis and biological applications

Advances in Hollow Inorganic Nanomedicines for Photothermal-Based Therapies

Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma

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Paramagnetic CuS hollow nanoflowers for T₂-FLAIR magnetic resonance imaging-guided thermochemotherapy of cancer