Paramagnetic colloidal ferrihydrite nanoparticles for MRI contrasting

Sokolov, I. L.; Cherkasov, V. R.; Vasilyeva, Alexandra V.; Bragina, V.A.; Nikitin, Maxim P.

doi:10.1016/j.colsurfa.2017.11.062

Cited by 16 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These peaks corresponded to (110) and (115) planes of 2-line ferrihydrite 30 , a low-crystalline iron oxyhydroxide species. This observation led us to speculate that the downstream degradation pathway of MIL-101 NPs through the full hydrolysis yielded ferrihydritean endogenous material, which was known to be deposited in the living organisms as the core of native ferritin 31 .…”

Section: Phosphate Binding Triggers Mil-101 Degradationmentioning

confidence: 99%

Flash drug release from nanoparticles accumulated in the targeted blood vessels facilitates the tumour treatment

et al. 2022

View full text Add to dashboard Cite

Tumour microenvironment hinders nanoparticle transport deep into the tissue precluding thorough treatment of solid tumours and metastatic nodes. We introduce an anticancer drug delivery concept termed FlaRE (Flash Release in Endothelium), which represents alternative to the existing approaches based on enhanced permeability and retention effect. This approach relies on enhanced drug-loaded nanocarrier accumulation in vessels of the target tumour or metastasised organ, followed by a rapid release of encapsulated drug within tens of minutes. It leads to a gradient-driven permeation of the drug to the target tissue. This pharmaceutical delivery approach is predicted by theoretical modelling and validated experimentally using rationally designed MIL-101(Fe) metal-organic frameworks. Doxorubicin-loaded MIL-101 nanoparticles get swiftly trapped in the vasculature of the metastasised lungs, disassemble in the blood vessels within 15 minutes and release drug, which rapidly impregnates the organ. A significant improvement of the therapeutic outcome is demonstrated in animal models of early and late-stage B16-F1 melanoma metastases with 11-fold and 4.3-fold decrease of pulmonary melanoma nodes, respectively.

show abstract

Section: Phosphate Binding Triggers Mil-101 Degradationmentioning

confidence: 99%

Flash drug release from nanoparticles accumulated in the targeted blood vessels facilitates the tumour treatment

et al. 2022

View full text Add to dashboard Cite

show abstract

“…One of the directions of research in biophysics is the interaction with biological structures such as proteins [12,13], liposomes and natural membranes [14], and cells [15]. In the medical field, the magnetic properties of the iron nanoparticles, including ferrihydrite nanoparticles (Fh-NPs), have been exploited in the field of the immunoassay [16], magnetic resonance imaging (MRI) [17], and magnetic particle imaging (MPI) for noninvasive imaging of inflammation processes [18], drug delivery [19], and hyperthermia [20]. The doping of nanoparticles can lead to an extension of their field of application by improving the physicochemical characteristics [21] such as the modification of their magnetic properties.…”

Section: Introductionmentioning

confidence: 99%

Interactions of Chemically Synthesized Ferrihydrite Nanoparticles with Human Serum Transferrin: Insights from Fluorescence Spectroscopic Studies

Chilom

Sandu

Iftimie

et al. 2021

IJMS

View full text Add to dashboard Cite

Human serum transferrin (HST) is a glycoprotein involved in iron transport that may be a candidate for functionalized nanoparticles to bind and target cancer cells. In this study, the effects of the simple and doped with cobalt (Co) and copper (Cu) ferrihydrite nanoparticles (Fh-NPs, Cu-Fh-NPs, and Co-Fh-NPs) were studied by spectroscopic and molecular approaches. Fluorescence spectroscopy revealed a static quenching mechanism for all three types of Fh-NPs. All Fh-NPs interacted with HST with low affinity, and the binding was driven by hydrogen bonding and van der Waals forces for simple Fh-NPs and by hydrophobic interactions for Cu-Fh-NPs and Co-Fh-NPs binding, respectively. Of all samples, simple Fh-NPs bound the most to the HST binding site. Fluorescence resonance energy transfer (FRET) allowed the efficient determination of the energy transfer between HST and NPs and the distance at which the transfer takes place and confirmed the mechanism of quenching. The denaturation of the HST is an endothermic process, both in the case of apo HST and HST in the presence of the three types of Fh-NPs. Molecular docking studies revealed that Fh binds with a low affinity to HST (Ka = 9.17 × 103 M−1) in accord with the fluorescence results, where the interaction between simple Fh-NPs and HST was described by a binding constant of 9.54 × 103 M−1.

show abstract

Efficiency of granulocyte colony-stimulating factor immobilized on magnetic microparticles on proliferation of NFS-60 cells

Popov

Stirkė

Bakute

et al. 2019

Colloids and Surfaces A: Physicochemical and Engineering Aspect

View full text Add to dashboard Cite

Paramagnetic colloidal ferrihydrite nanoparticles for MRI contrasting

Cited by 16 publications

References 42 publications

Flash drug release from nanoparticles accumulated in the targeted blood vessels facilitates the tumour treatment

Flash drug release from nanoparticles accumulated in the targeted blood vessels facilitates the tumour treatment

Interactions of Chemically Synthesized Ferrihydrite Nanoparticles with Human Serum Transferrin: Insights from Fluorescence Spectroscopic Studies

Efficiency of granulocyte colony-stimulating factor immobilized on magnetic microparticles on proliferation of NFS-60 cells

Contact Info

Product

Resources

About