Paralysie périodique thyréotoxique hypokaliémique : quatre observations et revue de la littérature

Boissier, Émilie; Georgin-Lavialle, S.; Cochereau, D.; Ducloux, R.; Ranque, Brigitte; Aslangul, E.; Pouchot, J.

doi:10.1016/j.revmed.2013.03.004

Cited by 5 publications

(6 citation statements)

References 36 publications

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“…The age at diagnosis is usually between the second and the fourth decade of life, 9 and our patient was 17 when he presented symptoms. In fact, less cases with adolescent onset have been reported compared to older age groups worldwide 4,9,10 . The triad that characterizes patients with TPP is hypokalemia, acute onset muscle weakness and hyperthyroidism 4,5,9 .…”

Section: Discussionmentioning

confidence: 99%

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A rare case of thyrotoxic periodic paralysis revealing Graves' disease in a young Malian

Dembélé,

Yalcouyé,

Cissoko

et al. 2024

Clinical Case Reports

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Sporadic thyrotoxic periodic paralysis (TPP) is a rare muscle disorder that manifests with abrupt muscle weakness and hypokalemia associated with hyperthyroidism. It is mostly reported in the Asian population, and rare in Caucasians. Only few cases have been reported in people with black ancestry. Here, we report a rare case of thyrotoxic periodic paralysis revealing Graves' disease in a young Malian. A 17‐year‐old man was admitted in the Neurology clinic with rapid proximal tetraplegia that started after strenuous physical activities at the school. Clinical examination confirmed the proximal weakness. In addition, he had bilateral ptosis, exophthalmia, and horizontal ophthalmoplegia. Laboratory testing showed normal serum potassium and creatinine, low calcium and TSH levels. However, CK, FT4, thyroid stimulating hormone antibody, and acetylcholine receptor antibody levels were high. In addition, electrocardiogram was normal while thyroid Doppler‐ultrasound showed heterogeneous, hypoechogenic, hypertrophic, and hyper vascularized gland. Patient had completely recovered his limb weakness within the following hours with symptomatic treatment. The clinical findings were consistent with Graves' disease, and he was put on Neomercazole. He did not present another episode of paralysis after 4‐years of follow up. This is a first case of thyrotoxic periodic paralysis reported in Mali and one of the rare cases in sub‐Saharan Africa. Despite its scarcity, all patients with acute weakness consecutive to effort, whether recurring or not, should be screened for TPP.

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Section: Discussionmentioning

confidence: 99%

“…In fact, less cases with adolescent onset have been reported compared to older age groups worldwide. 4,9,10 The triad that characterizes patients with TPP is hypokalemia, acute onset muscle weakness and hyperthyroidism. 4,5,9 The abrupt muscle weakness presented by this patient is the commonly reported clinical presentation.…”

Section: Discussionmentioning

confidence: 99%

A rare case of thyrotoxic periodic paralysis revealing Graves' disease in a young Malian

Dembélé,

Yalcouyé,

Cissoko

et al. 2024

Clinical Case Reports

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“…A study from Mayo Clinic reported 10 cases over 20 years, with a prevalence of 0.1-0.2% in thyrotoxic patients in North America [ 7 ]. While the condition predominantly presents in Chinese men [ 1 ], it has been reported in diverse ethnic groups, including Hispanic, Native American, Caucasian, Afro-Caribbean, Afro-Trinidadian, and African populations [ 5 , 8 - 12 ].…”

Section: Discussionmentioning

confidence: 99%

Recurrent Thyrotoxic Periodic Paralysis As the Sole Clinical Manifestation of Untreated Hyperthyroidism

Zavgorodneva,

Khan

2024

Cureus

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Thyrotoxic periodic paralysis (TPP) is a complication of hyperthyroidism that predominantly affects the Asian population. Episodes of muscle paralysis typically coincide with symptoms of hyperthyroidism. However, we present a unique case of TPP in a 32-year-old African American patient where TPP served as the primary manifestation of thyrotoxicosis. The patient was discharged with a resolution of symptoms after correcting electrolyte abnormalities.

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“…The disease is rare in blacks, with most cases having been reported in North America. A literature review revealed few cases reported in blacks of African ethnicity from Europe 2 , 4 – 6 . Although thyrotoxicosis is most often seen in females, TPP disproportionally affects men at a ratio of 20:1 7 .…”

Section: Discussionmentioning

confidence: 99%

“…TPP is more common in young Asian males than in Caucasians or Africans 2 , and the condition may be overlooked, creating the potential for misdiagnosis in the latter populations. Failure to recognize and treat this condition appropriately may lead to potentially lethal cardiopulmonary complications.…”

Section: Introductionmentioning

confidence: 99%

Thyrotoxic hypokalemic periodic paralysis in an African male: a case report

Belayneh¹,

Kellerth

2014

Clinical Case Reports

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Paralysie périodique thyréotoxique hypokaliémique : quatre observations et revue de la littérature

Cited by 5 publications

References 36 publications

A rare case of thyrotoxic periodic paralysis revealing Graves' disease in a young Malian

A rare case of thyrotoxic periodic paralysis revealing Graves' disease in a young Malian

Recurrent Thyrotoxic Periodic Paralysis As the Sole Clinical Manifestation of Untreated Hyperthyroidism

Thyrotoxic hypokalemic periodic paralysis in an African male: a case report

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