Parallels between astronauts and terrestrial patients – Taking physiotherapy rehabilitation “To infinity and beyond”

Hides, Julie; Lambrecht, Gunda; Ramdharry, Gita; Cusack, Rebecca; Bloomberg, Jacob J.; Stokes, María

doi:10.1016/j.msksp.2016.12.008

Cited by 14 publications

(13 citation statements)

References 58 publications

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“…A recent study reported that lessons learned from development of exercise strategies on Earth could inform programs for long duration missions. In particular, programs developed for people with low back pain (LBP) may have application as inflight exercise countermeasures (Hides et al, 2017). Since the last review was written in 2017, there have been considerable advancements in knowledge in the field of LBP research.…”

Section: Introductionmentioning

confidence: 99%

State-of-the-Art Exercise Concepts for Lumbopelvic and Spinal Muscles – Transferability to Microgravity

2019

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Low back pain (LBP) is the leading cause of disability worldwide. Over the last three decades, changes to key recommendations in clinical practice guidelines for management of LBP have placed greater emphasis on self-management and utilization of exercise programs targeting improvements in function. Recommendations have also suggested that physical treatments for persistent LBP should be tailored to the individual. This mini review will draw parallels between changes, which occur to the neuromuscular system in microgravity and conditions such as LBP which occur on Earth. Prolonged exposure to microgravity is associated with both LBP and muscle atrophy of the intrinsic muscles of the spine, including the lumbar multifidus. The finding of atrophy of spinal muscles has also commonly been reported in terrestrial LBP sufferers. Studying astronauts provides a unique perspective and valuable model for testing the effectiveness of exercise interventions, which have been developed on Earth. One such approach is motor control training, which is a broad term that can include all the sensory and motor aspects of spinal motor function. There is evidence to support the use of this exercise approach, but unlike changes seen in muscles of LBP sufferers on Earth, the changes induced by exposure to microgravity are rapid, and are relatively consistent in nature. Drawing parallels between changes which occur to the neuromuscular system in the absence of gravity and which exercises best restore size and function could help health professionals tailor improved interventions for terrestrial populations.

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Section: Introductionmentioning

confidence: 99%

State-of-the-Art Exercise Concepts for Lumbopelvic and Spinal Muscles – Transferability to Microgravity

2019

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“…Spaceflight and exposure to microgravity cause specific changes in human skeleton (Smith et al, 2012) and skeletal muscles (Belavý et al, 2011; Narici and de Boer, 2011). It is known that the disorders seen in astronauts after a space mission are similar to terrestrial neuromuscular diseases in patients (Hides et al, 2017). Studies of the neuromuscular system plasticity in astronauts are beneficial to patients with similar disorders, and, vice versa, researches with patients may provide new options for the reconditioning of astronauts (Stokes et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Mechanisms of HMS development are still poorly explored. Interestingly, pathognomonic signs are observed in skeletal muscles following spinal or peripheral nerve disorders (Hides et al, 2017). Earlier, it has been shown that the important trigger of HMS is violation of sensory impulses from the skin (Kozlovskaya et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

Bioinformatic Study of Transcriptome Changes in the Mice Lumbar Spinal Cord After the 30-Day Spaceflight and Subsequent 7-Day Readaptation on Earth: New Insights Into Molecular Mechanisms of the Hypogravity Motor Syndrome

et al. 2019

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The hypogravity motor syndrome (HMS) is one of the deleterious impacts of weightlessness on the human body in orbital space missions. There is a hypothesis that disorders of musculoskeletal system as part of HMS arise in consequence of changes in spinal motor neurons. The study was aimed at bioinformatic analysis of transcriptome changes in lumbar spinal cords of mice after a 30-day spaceflight aboard biosatellite Bion-M1 (space group, S) and subsequent 7-day readaptation to the Earth’s gravity (recovery group, R) when compared with control mice (C group) housed in simulated biosatellite conditions on the Earth. Gene ontology and human phenotype ontology databases were used to detect biological processes, molecular functions, cellular components, and human phenotypes associated with HMS. Our results suggest resemblance of molecular changes developing in space orbit and during the postflight recovery to terrestrial neuromuscular disorders. Remarkably, more prominent transcriptome changes were revealed in R vs. S and R vs. C comparisons that are possibly related to the 7-day recovery period in the Earth’s gravity condition. These data may assist with establishment of HMS pathogenesis and proposing effective preventive and therapeutic options.

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“…Parallels with deconditioning in areas of terrestrial rehabilitation, such as sports injuries, neurological disorders and intensive care may be helpful to draw on in the absence of studies on astronauts [31]. Simple, non-invasive ways of monitoring neuromusculoskeletal function are also needed.…”

Section: Future Directionmentioning

confidence: 99%

Postflight reconditioning for European Astronauts – A case report of recovery after six months in space

Petersen

Lambrecht

Scott

et al. 2017

Musculoskeletal Science and Practice

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Parallels between astronauts and terrestrial patients – Taking physiotherapy rehabilitation “To infinity and beyond”

Cited by 14 publications

References 58 publications

State-of-the-Art Exercise Concepts for Lumbopelvic and Spinal Muscles – Transferability to Microgravity

State-of-the-Art Exercise Concepts for Lumbopelvic and Spinal Muscles – Transferability to Microgravity

Bioinformatic Study of Transcriptome Changes in the Mice Lumbar Spinal Cord After the 30-Day Spaceflight and Subsequent 7-Day Readaptation on Earth: New Insights Into Molecular Mechanisms of the Hypogravity Motor Syndrome

Postflight reconditioning for European Astronauts – A case report of recovery after six months in space

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