Parallelizable microfluidic dropmakers with multilayer geometry for the generation of double emulsions

Nawar, Saraf; Stolaroff, Joshuah K.; Ye, Congwang; Wu, Huayin; Nguyen, Du T.; Feng, Xin; Weitz, David A.

doi:10.1039/c9lc00966c

Cited by 51 publications

(38 citation statements)

References 24 publications

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“…Therefore, some improvement measures are needed to solve this problem. Saraf Nawar et al (Nawar et al, 2020 ) proposed to parallelize the microfluidic device to realize a chip containing multiple droplet generators at the same time, as shown in Figure 4 . Such a droplet generator with a multi-layer geometry structure can greatly simplify the droplet production process and improve production efficiency (Peng et al, 2020 ).…”

Section: Preparation Methods Of Plga Microspherementioning

confidence: 99%

Section: Preparation Methods Of Plga Microspherementioning

confidence: 99%

“…As the solvent rapidly evaporates, the atomized droplets are transformed into solid particles (Shi et al, 2020;. The spray drying process usually includes four stages: atomization, droplet mixing with dry gas, solvent volatilization, and product separation, in which the technological conditions and parameters of the atomization process play a decisive role in the droplet size distribution (R e, 2006; Liu et Adapted with permission from Reference (Nawar et al, 2020). Copyright 2020, Royal Society of Chemistry.…”

Section: Spray Dryingmentioning

confidence: 99%

“…Inset shows the simultaneous operation of two adjacent drop makers of the parallel chip. (b) Photograph of the parallelized microfluidic device.Adapted with permission from Reference(Nawar et al, 2020). Copyright 2020, Royal Society of Chemistry.…”

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confidence: 99%

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PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

264

106

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Biodegradable microspheres have been widely used in the field of medicine due to their ability to deliver drug molecules of various properties through multiple pathways and their advantages of low dose and low side effects. Poly (lactic-co-glycolic acid) copolymer (PLGA) is one of the most widely used biodegradable material currently and has good biocompatibility. In application, PLGA with a specific monomer ratio (lactic acid and glycolic acid) can be selected according to the properties of drug molecules and the requirements of the drug release rate. PLGA-based biodegradable microspheres have been studied in the field of drug delivery, including the delivery of various anticancer drugs, protein or peptide drugs, bacterial or viral DNA, etc. This review describes the basic knowledge and current situation of PLGA biodegradable microspheres and discusses the selection of PLGA polymer materials. Then, the preparation methods of PLGA microspheres are introduced, including emulsification, microfluidic technology, electrospray, and spray drying. Finally, this review summarizes the application of PLGA microspheres in drug delivery and the treatment of pulmonary and ocularrelated diseases.

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Section: Preparation Methods Of Plga Microspherementioning

confidence: 99%

Section: Preparation Methods Of Plga Microspherementioning

confidence: 99%

Section: Spray Dryingmentioning

confidence: 99%

mentioning

confidence: 99%

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PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

264

106

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“…34,35 Recent advances on microfluidic systems have been used for larger-scale production of water-in-oil-in-water emulsions, producing up to ~50 g.h -1 . 36,37 Furthermore, a combination of large-scale production and machine learning can be used to minimise the need for a human operator checking the continuous production. 38,39 Here, the high throughput production of microcapsules using microfluidics for mechanically triggered self-healing in the cementitious matrix was investigated.…”

Section: Introductionmentioning

confidence: 99%

High throughput production of microcapsules using microfluidics for self-healing of cementitious materials

Souza

Al‐Tabbaa

2021

Lab Chip

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Micro‐Patterning Wettability in Very Large Scale Microfluidic Integrated Chips for Double Emulsion Generation

Wu,

Hwang,

Yadavali

et al. 2023

Adv Funct Materials

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The fabrication of microfluidic chips is becoming a mature field and channels can be reliably defined with micrometer‐scale precision in a variety of substrates. In addition to channel geometry, micrometer‐scale patterning of wettability in microfluidic channels is essential for many applications including multi‐phase flow stabilization and multiple emulsion generation. Unfortunately, current methods to pattern wettability in microfluidics suffer from low spatial resolution, inability for patterns to be arbitrarily defined, cumbersome procedures, and incompatibility with parallelized architectures for scaled‐up production of microfluidic generated materials. To address these issues, a method is developed to lithographically define micrometer‐scale resolution patterns of wettability on all channel surfaces (ceiling, floor, and walls) in silicon and glass microfluidic devices with complex 3D geometry. A process is reported to pattern silanes on microfluidic chips that uses photolithography and an optimized process that keeps silanized surfaces stable through the microfabrication process, including anodic bonding. The versatility of this approach is highlighted by patterning wettability of a silicon/glass device to generate both highly uniform water–in‐oil–in‐water and oil–in‐water–in‐oil double emulsions. The applicability of this process is demonstrated to the parallel generation of materials in a microfluidic chip with complex geometry, by fabricating and successfully validating parallelized double emulsion generators.

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Parallelizable microfluidic dropmakers with multilayer geometry for the generation of double emulsions

Abstract: We present a multilayer dropmaker geometry that enables the modular fabrication of microfluidic devices containing precisely patterned channel surface wettability. The platform is used for the scalable production of uniform double emulsion drops.

Cited by 51 publications

References 24 publications

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

High throughput production of microcapsules using microfluidics for self-healing of cementitious materials

Micro‐Patterning Wettability in Very Large Scale Microfluidic Integrated Chips for Double Emulsion Generation

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