Parallelism between Avoidance-Suppressing and Prolactin-Increasing Effects of Antipsychotic Drugs in Rats

Hayashi, Tetsu; Tadokoro, Sakutaro

doi:10.1254/jjp.35.451

Cited by 9 publications

(5 citation statements)

References 23 publications

(6 reference statements)

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“…The hospital record provided neuroleptic dose and benzodiazepine doses given. Neuroleptic dose was converted to chlorpromazine equivalents 38,39 and benzodiazepine dose to diazepam equivalents 40 …”

Section: Methodsmentioning

confidence: 99%

Quantitative Drug Levels in Stimulant Psychosis: Relationship to Symptom Severity, Catecholamines and Hyperkinesia

Batki

Harris

2004

American J Addict

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To examine the relationship between quantitative stimulant drug levels, catecholamines, and psychotic symptoms, nineteen patients in a psychiatric emergency service with a diagnosis of amphetamine- or cocaine-induced psychosis were interviewed, and plasma and urine were collected for quantitative assays of stimulant drug and catecholamine metabolite levels. Methamphetamine or amphetamine levels were related to several psychopathology scores and the global hyperkinesia rating. HVA levels were related to global hyperkinesia but not to psychopathology ratings. Although many other factors such as sensitization may play a role, intensity of stimulant-induced psychotic symptoms and stereotypies appears to be at least in part dose-related.

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Section: Methodsmentioning

confidence: 99%

Quantitative Drug Levels in Stimulant Psychosis: Relationship to Symptom Severity, Catecholamines and Hyperkinesia

Batki

Harris

2004

American J Addict

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“…The hospital record provided information for measures of two emergency treatment interventions: number of hours in seclusion and neuroleptic dose given. Neuroleptic dose was converted to chlorpromazine equivalents 28,29 . Hospital records provided length of stay in PES (which serves as an acute inpatient unit usually for stays of less than 24 hours) and length of total hospital stay.…”

Section: Methodsmentioning

confidence: 99%

Stimulant Psychosis: Symptom Profile and Acute Clinical Course

Harris

2000

American J Addict

127

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Nineteen patients seen at a psychiatric emergency service with amphetamine- or cocaine-induced psychotic disorder were assessed with structured interviews, chart review, and blood and urine testing. All had a predominance of positive symptoms from the Positive and Negative Syndrome Scale (PANSS). However, some subjects had substantial Negative Scale scores (26%), bizarre delusions (95%), and Schneiderian hallucinations (63%), mimicking a broad range of schizophrenic symptoms. Several PANSS scores were correlated with treatment intensity: Positive score with seclusion hours, General Psychopathology and Negative scores with hospitalization length, and General Psychopathology score with neuroleptic dose. Presenting symptoms may help in treatment planning.

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“…A report by Kondo et al (2000) showed that prolactin levels increase about 3-fold (on average) with age in male chimpanzees. However, this report does not specify how long the blood sample was taken after administering ketamine and the dopamine D 2 -like antagonist droperidol, and both of these agents increase prolactin (Puri, Puri & Anand Kumar, 1981; Hayashi & Tadokoro, 1984; Schettini et al, 1989; Rizvi et al, 2001; Hergovich et al, 2001). For comparison, human males have no significant differences in prolactin levels from prepubescence to adulthood (Guyda & Friesen, 1973; Aubert, Grumbach & Kaplan, 1974; Lee, Jaffe & Midgley, 1974; Ehara, Yen & Siler, 1975; Finkelstein et al, 1978).…”

Section: Discussionmentioning

confidence: 99%

Prolactin and fMRI response to SKF38393 in the baboon

Miller

Marks

Koller

et al. 2013

PeerJ

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Background. This study’s goal was to provide dose–response data for a dopamine agonist in the baboon using standard methods (replicate measurements at each dose, across a range of doses), as a standard against which to subsequently validate a novel pharmacological MRI (phMRI) method. Dependent variables were functional MRI (fMRI) data from brain regions selected a priori, and systemic prolactin release. Necessary first steps included estimating the magnitude and time course of prolactin response to anesthesia alone and to various doses of agonist. These first steps (“time course studies”) were performed with three agonists, and the results were used to select promising agonists and to guide design details for the single-dose studies needed to generate dose–response curves.Methods. We studied 6 male baboons (Papio anubis) under low-dose isoflurane anesthesia after i.m. ketamine. Time course studies charted the changes in plasma prolactin levels over time after anesthesia alone or after an intravenous (i.v.) dose of the dopamine D1-like agonists SKF82958 and SKF38393 or the D2-like agonist pramipexole. In the single-dose dopamine agonist studies, one dose of SKF38393 (ranging from 0.0928–9.28 mg/kg, N = 5 animals) or pramipexole (0.00928–0.2 mg/kg, N = 1) was given i.v. during a 40-min blood oxygen level dependent (BOLD) fMRI session, to determine BOLD and plasma prolactin responses to different drug concentrations. BOLD response was quantified as the area under the time-signal curve for the first 15 min after the start of the drug infusion, compared to the linearly predicted signal from the baseline data before drug. The ED50 (estimated dose that produces 50% of the maximal possible response to drug) for SKF38393 was calculated for the serum prolactin response and for phMRI responses in hypothalamus, pituitary, striatum and midbrain.Results. Prolactin rose 2.4- to 12-fold with anesthesia alone, peaking around 50–90 min after ketamine administration and gradually tapering off but still remaining higher than baseline on isoflurane 3–5 h after ketamine. Baseline prolactin level increased with age. SKF82958 0.1 mg/kg i.v. produced no noticeable change in plasma prolactin concentration. SKF38393 produced a substantial increase in prolactin release that peaked at around 20–30 min and declined to pre-drug levels in about an hour. Pramipexole quickly reduced prolactin levels below baseline, reaching a nadir 2–3 h after infusion. SKF38393 produced clear, dose-responsive BOLD signal changes, and across the four regions, ED50 was estimated at 2.6–8.1 mg/kg.Conclusions. In the baboon, the dopamine D1 receptor agonist SKF38393 produces clear plasma prolactin and phMRI dose–response curves. Variability in age and a modest sample size limit the precision of the conclusions.

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Parallelism between Avoidance-Suppressing and Prolactin-Increasing Effects of Antipsychotic Drugs in Rats

Cited by 9 publications

References 23 publications

Quantitative Drug Levels in Stimulant Psychosis: Relationship to Symptom Severity, Catecholamines and Hyperkinesia

Quantitative Drug Levels in Stimulant Psychosis: Relationship to Symptom Severity, Catecholamines and Hyperkinesia

Stimulant Psychosis: Symptom Profile and Acute Clinical Course

Prolactin and fMRI response to SKF38393 in the baboon

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