Parallel tubular arrays in severe combined immunodeficiency disease: an ultrastructural study of peripheral blood lymphocytes

Payne, CM; Sieber, OF; Va, Fulginiti

doi:10.1182/blood.v50.1.55.bloodjournal50155

Cited by 11 publications

(1 citation statement)

References 14 publications

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“…MTRS were first described by Chandra in lymphoblasts of a leukocyte culture, 39,40 and have most frequently been described in endothelial cells and peripheral blood lymphocytes of active systemic lupus erythematosus and miscellaneous viral infections and neoplastic conditions: systemic endothelia and circulating lymphocytes in HIV infection, 35,36,41,42 Herpes simplex, and human eastern equine encephalitis, and children with severe combined immunodeficiency diseases. 43,44 These structures were also noticed in two B-cell lines of infectious mononucleosis and tumor cells of Burkitt-type lymphoma, 45,46 germinoma, and interdigitating cell sarcoma.…”

Section: Discussionmentioning

confidence: 99%

Follicular dendritic cell sarcoma with microtubuloreticular structure and virus‐like particle production in vitro

Ono

Terashima²,

Liu³

et al. 2009

Pathology International

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Neoplasm of follicular dendritic cells (FDC), follicular dendritic cell sarcoma (FDCS), is a rare tumor of intermediate to high-grade malignancy in lymph nodes and visceral organs. Reported herein is a case of FDCS arising from cervical lymph nodes in a 16-year-old Japanese boy, who died of the disease 3 years after diagnosis. The tumor cells were pale eosinophilic and elongated with euchromatic nuclei and were positive for CD21, clusterin, and CNA-42 on immunohistochemistry, as well as desmosome-like junctions on electron microscopy. The presence of microtubuloreticular structures (MTRS) in the tumor cells and associated lymphocytes characterized this case, suggesting some viral infection, although qualitative polymerase chain reaction of genomic and complementary DNA obtained from the tumor failed to demonstrate any viral infection at the laboratory level. The stimulation of dispersed tumor cells and peripheral blood mononuclear cells with mAb to CD3 and interleukin-2 was attempted; and the cell line established by the authors (FDCS-Sa) was stimulated with iododeoxyuridine. Virus-like particles (VLP) were successfully induced from each cellular source. The VLP, 100 nm in diameter, showed an electron-dense thorny envelope and granular core. This is the first case of FDCS with MTRS accompanying VLP production in vitro.

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Section: Discussionmentioning

confidence: 99%

Follicular dendritic cell sarcoma with microtubuloreticular structure and virus‐like particle production in vitro

Ono

Terashima²,

Liu³

et al. 2009

Pathology International

View full text Add to dashboard Cite

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Effect of sera from patients with Hodgkin's disease on normal donor lymphocytes containing parallel tubular structures

Smit

Blom

Luyn

et al. 1984

Blut

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Normal donor peripheral blood mononuclear cells incubated for 24 h with sera from patients with Hodgkin's disease were investigated by electron microscopy for the presence of parallel tubular structures (PTS) and/or amorphous electrondense granules (large granular lymphocytes = LGL). In comparison with normal human serum, 14 out of 29 sera of the patients induced a marked increase in the percentage of LGL. From a limited number of experiments it was likely that this increase is paralleled by an increase in Fcgamma receptor-bearing cells after the incubation. This serum effect did not show a correlation with the number of Fcgamma receptor-positive lymphocytes in the peripheral blood of the patients. A difference in the induction effect could be demonstrated between the sera from patients with a favourable and those with an unfavourable clinical course, but this distinction was not absolute. The presence or absence of splenic involvement by Hodgkin's disease does not apparently influence the effect of the sera. From experiments using sera positive for immune complexes or anti-Epstein-Barr virus antibodies, it seems unlikely that these factors are responsible for the observed increase in LGL.

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Lymphocytes with parallel tubular structures: Morphologically a distinctive subpopulation

Smit

Blom

Luyn

et al. 1983

Blut

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Peripheral blood lymphocytes were fractionated in T, B and Null cell enriched subsets by means of sheep red blood cell rosette (ESRBC) sedimentation and nylon wool adherence. The ultrastructural features of these subpopulation were investigated. The T cell fraction in which the sheep erythrocytes were removed from the ESRBC rosette-forming cells (ESRBC-RFC) by lysis with ammonium chloride, consisted mainly of two morphologically distinctive subsets. The majority of the cells (80%) displayed a smooth surface membrane and had a high nuclear to cytoplasmic ratio with few cytoplasmic organelles. The other cell type (18%) had a relatively rough surface membrane, a low nuclear to cytoplasmic ratio, often an indented nucleus and numerous cytoplasmic organelles such as characteristic amorphous granules and sometimes parallel tubular structures (p.t.s.). If the T cells were obtained after mechanical vibration of the ESRBC-RFC, the majority of these cells appeared morphologically identical to this latter cell type. Cells with p.t.s. and amorphous granules were also demonstrated within the Null and B cell enriched fractions (50% and 25% respectively), though in the B cell enriched fraction this cell type is probably due to a contamination of Null cells. Previous observations had already demonstrated that these cells in the three fractions represent the Fc gamma receptor-bearing lymphocytes. The similarities suggest that the Fc gamma receptor-bearing and p.t.s. containing lymphocytes form a morphologically distinct subpopulation.

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Parallel tubular arrays in severe combined immunodeficiency disease: an ultrastructural study of peripheral blood lymphocytes

Cited by 11 publications

References 14 publications

Follicular dendritic cell sarcoma with microtubuloreticular structure and virus‐like particle production in vitro

Follicular dendritic cell sarcoma with microtubuloreticular structure and virus‐like particle production in vitro

Effect of sera from patients with Hodgkin's disease on normal donor lymphocytes containing parallel tubular structures

Lymphocytes with parallel tubular structures: Morphologically a distinctive subpopulation

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