Parallel transcriptomic changes in the origins of divergent monogamous vertebrates?

Jiang, Daohan; Zhang, Jianzhi

doi:10.1073/pnas.1910749116

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…In fact, only one other combination of species exhibited more differentially expressed genes (Supplementary Table S2). Comparing the two most closely related non-cleaner species to the remaining three species yield 981 differentially expressed genes, highlighting the role of evolutionary history in shaping gene expression patterns (13,101,102).…”

Section: Parallel Gene Expression and Co-expression Patterns Underlie...mentioning

confidence: 99%

Shared neural transcriptomic patterns underlie the repeated evolution of mutualistic cleaning behavior in Labridae wrasses

Young¹,

Weitekamp²,

Triki³

et al. 2022

Preprint

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Despite the remarkable diversity of life forms on earth, evolutionary biologists have discovered numerous instances where even distantly related species share astonishing similarities in how they behave, look, and function. Given the importance of happenstance in evolution (e.g., random mutations, genetic drift, environmental stochasticity), it is often assumed that the mechanisms underlying such convergent phenotypes are distinct. Nevertheless, recent discoveries that the same pathways can underlie convergently evolved phenotypes have reinvigorated questions about the predictability of evolution and whether broadly conserved genomic mechanisms facilitate phenotypic convergence. Here, we generated transcriptomes of the putative teleost homologs of the mammalian hippocampus and basolateral amygdala, broadly associated with spatial and social cognition, in six sympatric species of Labridae wrasses that vary in mutualistic cleaning behavior (including three non-cleaning, two facultative cleaning, and one obligate cleaning species) and combined differential gene expression, gene co-expression, and phylogenetic comparative analyses to test two hypotheses about convergent evolution and specialization of mutualistic cleaning behavior. We first identify genes and gene modules exhibiting parallel neurotranscriptomic patterns in the repeated evolution of facultative cleaning. We then examined whether expression and co-expression patterns associated with facultative cleaning are also shared in the obligate cleaner species in our dataset and found evidence for transcriptomic concordance, though no evidence for additional specialization. Taken together, our results provide insights into the convergent evolution and the neuromolecular basis of cooperative behavior and, more generally, illustrate the potential of phylogenetic comparative transcriptomics to unravel the mechanistic underpinnings of the repeated evolution of complex organismal phenotypes.

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Section: Parallel Gene Expression and Co-expression Patterns Underlie...mentioning

confidence: 99%

Shared neural transcriptomic patterns underlie the repeated evolution of mutualistic cleaning behavior in Labridae wrasses

Young¹,

Weitekamp²,

Triki³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Reply to Jiang and Zhang: Parallel transcriptomic signature of monogamy: What is the null hypothesis anyway?

Young

Hofmann

2019

Proc. Natl. Acad. Sci. U.S.A.

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Evolution of gene expression across brain regions in behaviourally divergent deer mice

Kautt,

Chen,

Lewarch

et al. 2024

Molecular Ecology

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The evolution of innate behaviours is ultimately due to genetic variation likely acting in the nervous system. Gene regulation may be particularly important because it can evolve in a modular brain‐region specific fashion through the concerted action of cis‐ and trans‐regulatory changes. Here, to investigate transcriptional variation and its regulatory basis across the brain, we perform RNA sequencing (RNA‐Seq) on ten brain subregions in two sister species of deer mice (Peromyscus maniculatus and P. polionotus)—which differ in a range of innate behaviours, including their social system—and their F1 hybrids. We find that most of the variation in gene expression distinguishes subregions, followed by species. Interspecific differential expression (DE) is pervasive (52–59% of expressed genes), whereas the number of DE genes between sexes is modest overall (~3%). Interestingly, the identity of DE genes varies considerably across brain regions. Much of this modularity is due to cis‐regulatory divergence, and while 43% of genes were consistently assigned to the same gene regulatory class across subregions (e.g. conserved, cis‐ or trans‐regulatory divergence), a similar number were assigned to two or more different gene regulatory classes. Together, these results highlight the modularity of gene expression differences and divergence in the brain, which may be key to explain how the evolution of brain gene expression can contribute to the astonishing diversity of animal behaviours.

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Parallel transcriptomic changes in the origins of divergent monogamous vertebrates?

Cited by 3 publications

References 5 publications

Shared neural transcriptomic patterns underlie the repeated evolution of mutualistic cleaning behavior in Labridae wrasses

Shared neural transcriptomic patterns underlie the repeated evolution of mutualistic cleaning behavior in Labridae wrasses

Reply to Jiang and Zhang: Parallel transcriptomic signature of monogamy: What is the null hypothesis anyway?

Evolution of gene expression across brain regions in behaviourally divergent deer mice

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