Parallel Synthesis of Piperazine Tethered Thiazole Compounds with Antiplasmodial Activity
Ramanjaneyulu Rayala,
Prakash Chaudhari,
Ashley Bunnell
et al.
Abstract:Thiazole and piperazine are two important heterocyclic rings that play a prominent role in nature and have a broad range of applications in agricultural and medicinal chemistry. Herein, we report the parallel synthesis of a library of diverse piperazine-tethered thiazole compounds. The reaction of piperazine with newly generated 4-chloromethyl-2-amino thiazoles led to the desired piperazine thiazole compounds with high purities and good overall yields. Using a variety of commercially available carboxylic acids… Show more
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