Parallel solid-phase synthesis of a small library of linear and hydrocarbon-bridged analogues of VEGF81–91: Potential biological tools for studying the VEGF/VEGFR-1 interaction

Design and Synthesis of C-Terminal Modified Cyclic Peptides as VEGFR1 Antagonists

“…Many efforts have been pursued in the search of antagonists of VEGF/VEGFR interactions based on the available structural data. From both the α1 helix sequence VEGF 16–25 (KFMDVYQRSY) and the β5-β6 loop hairpin sequence VEGF 79–96 (QIMRIKPHQGQHIGEMSF), linear or cyclic peptides and peptidomimetics have been developed [14,15,16,17,18,19,20,21]. Some of them have shown anti-angiogenic effects on in vivo assays and tumor growth inhibition on animal model [16,20,21,22,23], however, surprisingly, some designed peptides showed pro-angiogenic effects [21,24].…”

Peptide-loaded Nanoparticles and Radionuclide Imaging for Individualized Treatment of Myocardial Ischemia

“…Preparation of Chitosan Hydrogels, Loading of Angiogenic Factors, and Technetium 99m Labeling Recombinant rat VEGF 165 proteins and VEGF 81-91 peptides (sequence: MRIK-PHQGQHI) (17)(18)(19) were purchased (PeproTech, Rocky Hill, NJ), along with the chitosan used in this study (Youngchipharm, Paju, South Korea).…”

“…For technetium 99m ( 99m Tc) imaging, chitosan-diethyltriaminepentaacetic resides within the 81-91 (sequence: MRIKPHQGQHI) fragment of VEGF that has proven interaction with VEGF receptors (17)(18)(19). Given that a drug delivery system is an effective tool to treat myocardial ischemia with proven capability of selective tissue targeting and retention, we hypothesized that the combined use of VEGF peptides (81-91 fragments) with the angiogenic potency could promote therapeutic angiogenesis.…”

Liposomal angiogenic peptides for ischemic limb perfusion: comparative study between different administration methods

“…With this approach, the loading efficiency of the angiogenic peptides obtained after extrusion and purification was 65% (Hwang et al, 2015). Angiogenic peptides (MRIKPHQGQHI) were derived from vascular endothelial growth factor (VEGF, sequence 81-91; Peptron, Daejeon, Korea), which have been demonstrated to have the angiogenic capability of the protein (Muller et al, 1998;Garcia-Aranda et al, 2011a;Garcia-Aranda et al, 2011b).…”