Parallel Processing of Sound Dynamics across Mouse Auditory Cortex via Spatially Patterned Thalamic Inputs and Distinct Areal Intracortical Circuits

Liu, Ji; Whiteway, Matthew R; Sheikhattar, Alireza; Butts, Daniel A.; Babadi, Behtash; Kanold, Patrick O.

doi:10.1016/j.celrep.2019.03.069

Cited by 93 publications

(173 citation statements)

References 82 publications

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“…To investigate the functional responses of A1 neurons and their functional organization, we performed in vivo 2-photon imaging in awake animals chronically implanted with cranial windows (Meng et al, 2017;Liu et al, 2019) using GCaMP6s expression. As done previously we performed widefield imaging to localize the imaging fields to A1 (Meng et al, 2017;Liu et al, 2019). We acquired L2/3 and L4 data sets sequentially in the same mouse ensuring that we imaged in the same tonotopic position in the mid-frequency region (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…While many A1 neurons have a maximal response during the stimulus, A1 neurons can also have offset responses to tones which can be separated from each other with long (>1s) stimuli (Liu et al, 2019). We measured how many neurons had significant onset (tone-on) responses versus offset (tone-off) responses (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…While on large scales A1 in rodents shows a tonotopic organization, nearby neurons can show different frequency preference (Bandyopadhyay et al, 2010;Rothschild et al, 2010;Winkowski and Kanold, 2013;Kanold et al, 2014;Li et al, 2017;Meng et al, 2017;Panniello et al, 2018;Liu et al, 2019;Tischbirek et al, 2019;Zeng et al, 2019). We thus investigated if this local heterogeneity varied between mouse strains.…”

Section: Cba Mice Have a Higher Local Heterogeneity Of Frequency Prefmentioning

confidence: 99%

“…The primary auditory cortex (A1) plays a key role for sound perception since it represents one of the first cortical processing stations for sounds. Recent studies have investigated the functional organization and circuitry of mouse auditory cortex (Bandyopadhyay et al, 2010;Rothschild et al, 2010;Li et al, 2017;Meng et al, 2017;Liu et al, 2019;Tischbirek et al, 2019). A classic hallmark of A1 organization in all species has been the discovery of tonotopic maps which describe a smooth distribution of tone preference across the surface of the primary and secondary auditory fields when probed with low spatial resolution techniques (Merzenich et al, 1975;Reale and Imig, 1980;Stiebler et al, 1997;Wessinger et al, 1997;Nelken et al, 2004;Bizley et al, 2005;Woods et al, 2010;Striem-Amit et al, 2011;van Dijk and Langers, 2013;Issa et al, 2014;Moerel et al, 2014;Baba et al, 2016;Liu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Functional Organization of Mouse Primary Auditory Cortex in adult C57BL/6 and F1 (CBAxC57) mice

Bowen

Winkowski

2019

Preprint

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The primary auditory cortex (A1) plays a key role for sound perception since it represents one of the first cortical processing stations for sounds. Recent studies have shown that on the cellular level the frequency organization of A1 is more heterogeneous than previously appreciated. However, many of these studies were performed in mice on the C57BL/6 background which develop high frequency hearing loss with age making them a less optimal choice for auditory research. In contrast, mice on the CBA background retain better hearing sensitivity in old age.Since potential strain differences could exist in A1 organization between strains, we performed comparative analysis of neuronal populations in A1 of adult (~10 weeks) C57BL/6 mice and CBAxC57 F1 mice. We used in vivo 2-photon imaging of pyramidal neurons in cortical layers L4 and L2/3 of awake mouse primary auditory cortex (A1) to characterize the populations of neurons that were active to tonal stimuli. Pure tones recruited neurons of widely ranging frequency preference in both layers and strains with neurons in CBA mice exhibiting a wider range of frequency preference particularly to higher frequencies. Frequency selectivity was slightly higher in C57BL/6 mice while neurons in CBA mice showed a greater sound-level sensitivity. The spatial heterogeneity of frequency preference was present in both strains with CBA mice exhibiting higher tuning diversity across all measured length scales. Our results demonstrate that the tone evoked responses and frequency representation in A1 of adult C57BL/6 and CBAxC57 F1 mice is largely similar.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Cba Mice Have a Higher Local Heterogeneity Of Frequency Prefmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Functional Organization of Mouse Primary Auditory Cortex in adult C57BL/6 and F1 (CBAxC57) mice

Bowen

Winkowski

2019

Preprint

Self Cite

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“…In parallel, due to less evidence of offset-responsive neurons in anaesthetized animals, OFF cortical responses have received comparably less attention. Yet, OFF responses have been observed in awake animals throughout the auditory pathway, and in the mouse auditory cortex they constitute from 30% to 70% of the responsive neurons (Scholl et al, 2010;Keller et al, 2018;Joachimsthaler et al, 2014;Liu et al, 2019a;Sollini et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Network dynamics underlying OFF responses in the auditory cortex

Bondanelli

Deneux

Bathellier

et al. 2019

Preprint

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Across sensory systems, complex spatio-temporal patterns of neural activity arise following the onset (ON) and offset (OFF) of simple stimuli. While ON responses have been widely studied, the mechanisms generating OFF responses in cortical areas have so far not been fully elucidated. Recent studies have argued that OFF responses reflect strongly transient sensory coding at the population level, suggesting they may be generated by a collective, network mechanism. We examine here the hypothesis that OFF responses are single-cell signatures of network dynamics and propose a simple model that generates transient OFF responses through recurrent interactions. To test this hypothesis, we analyse the responses of large populations of neurons in auditory cortex recorded using two-photon calcium imaging in awake mice passively listening to auditory stimuli. Adopting a population approach, we find that the OFF responses evoked by individual stimuli define trajectories of activity that evolve in low-dimensional neural subspaces. A geometric analysis of the population OFF responses reveals that, across different stimuli, these neural subspaces lie on largely orthogonal dimensions that define low-dimensional transient coding channels. We show that a linear network model with recurrent interactions provides a simple mechanism for the generation of the strong OFF responses observed in auditory cortex, and accounts for the low-dimensionality of the transient channels and their global structure across stimuli. We finally compare the network model with a single-cell mechanism and show that the single-cell model, while explaining some prominent features of the data, does not account for the structure across stimuli captured by the network model.

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Mechanically Tissue‐Like and Highly Conductive Au Nanoparticles Embedded Elastomeric Fiber Electrodes of Brain–Machine Interfaces for Chronic In Vivo Brain Neural Recording

Won

Jeong

Lee

et al. 2022

Adv Funct Materials

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Implantable neural probes are a crucial part of brain-machine interfaces that serve as direct interacting routes between neural tissues and machines. The neural probes require both mechanical and electrical properties to acquire high-quality signals from individual neurons with minimal tissue damage. However, overcoming the trade-off between flexibility and electrical property is still challenging. Herein, a fiber neural probe, composed of core polymer and Au nanoparticles (AuNPs) on the outer shell, is fabricated by absorbing Au precursor following in situ chemical reduction with a variation of percolating and leaching time. The proposed fiber exhibits excellent electrical properties, with an electrical conductivity of 7.68 × 10 4 S m −1 and an impedance of 2.88 × 10 3 Ω at 1 kHz, as well as a Young's modulus of 170 kPa, which is comparable to that of brain tissue (≈100 kPa). Additionally, the AuNPs fiber neural probe demonstrates extremely stable in vivo electrophysiological signal recordings for four months with reduced foreign body responses at the tissue-probe interface. Furthermore, this innovative approach encourages a new paradigm of long-term recording in the fields of neuroscience and engineering to better understand brain circuits, develop bioelectronic devices, and treat chronic disorders.

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Parallel Processing of Sound Dynamics across Mouse Auditory Cortex via Spatially Patterned Thalamic Inputs and Distinct Areal Intracortical Circuits

Cited by 93 publications

References 82 publications

Functional Organization of Mouse Primary Auditory Cortex in adult C57BL/6 and F1 (CBAxC57) mice

Functional Organization of Mouse Primary Auditory Cortex in adult C57BL/6 and F1 (CBAxC57) mice

Network dynamics underlying OFF responses in the auditory cortex

Mechanically Tissue‐Like and Highly Conductive Au Nanoparticles Embedded Elastomeric Fiber Electrodes of Brain–Machine Interfaces for Chronic In Vivo Brain Neural Recording

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