Parallel pathways from whisker and visual sensory cortices to distinct frontal regions of mouse neocortex

Kyriakatos, Alexandros; Matéo, Céline; Jaeger, Dieter; Petersen, Carl C. H.

doi:10.1117/1.nph.4.3.031203

Cited by 23 publications

(22 citation statements)

References 55 publications

(86 reference statements)

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“…The database supports that the MO s and the V RL/A/AL are strongly linked with each other. In addition, the database confirms the parallel reciprocal pathways reported in the frontal-parieto-occipital cortex 44 , 45 ; the secondary motor area ~0.5 mm rostrolateral to our injection site is reciprocally linked with the primary somatosensory cortex (Supplementary Fig. 12e, l ), and the dorsal part of the anterior cingulate area is linked with the V1 (Supplementary Fig.…”

Section: Resultssupporting

confidence: 84%

Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task

et al. 2018

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Cortical computation is distributed across multiple areas of the cortex by networks of reciprocal connectivity. However, how such connectivity contributes to the communication between the connected areas is not clear. In this study, we examine the communication between sensory and motor cortices. We develop an eye movement task in mice and combine it with optogenetic suppression and two-photon calcium imaging techniques. We identify a small region in the secondary motor cortex (MOs) that controls eye movements and reciprocally connects with a rostrolateral part of the higher visual areas (VRL/A/AL). These two regions encode both motor signals and visual information; however, the information flow between the regions depends on the direction of the connectivity: motor information is conveyed preferentially from the MOs to the VRL/A/AL, and sensory information is transferred primarily in the opposite direction. We propose that reciprocal connectivity streamlines information flow, enhancing the computational capacity of a distributed network.

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Section: Resultssupporting

confidence: 84%

Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task

et al. 2018

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“…We did see a fast increase in local field potential amplitude (latency of approximately 50 ms, data not shown) after the first touch for each trial, but we cannot exclude the possibility that this local field potential carries multimodal information. When the mPFC does not encode sensory information directly, the alternative explanation could be that sensory information from primary sensory cortices is summarized by feature extraction and/or categorization (Hanks et al, 2015 ) in an upstream brain region, e.g., the more dorsal parts of frontal cortex (Sreenivasan et al, 2017 ) or the orbitofrontal cortex as has been suggested by Euston et al ( 2012 ), since there is strong innervation from both these regions to mPFC (Hoover and Vertes, 2007 ). During our task we do not identify specific sensory spiking patterns.…”

Section: Discussionmentioning

confidence: 99%

Neural Representation of Motor Output, Context and Behavioral Adaptation in Rat Medial Prefrontal Cortex During Learned Behavior

Haan

Lim

Burg

et al. 2018

Front. Neural Circuits

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Selecting behavioral outputs in a dynamic environment is the outcome of integrating multiple information streams and weighing possible action outcomes with their value. Integration depends on the medial prefrontal cortex (mPFC), but how mPFC neurons encode information necessary for appropriate behavioral adaptation is poorly understood. To identify spiking patterns of mPFC during learned behavior, we extracellularly recorded neuronal action potential firing in the mPFC of rats performing a whisker-based “Go”/“No-go” object localization task. First, we identify three functional groups of neurons, which show different degrees of spiking modulation during task performance. One group increased spiking activity during correct “Go” behavior (positively modulated), the second group decreased spiking (negatively modulated) and one group did not change spiking. Second, the relative change in spiking was context-dependent and largest when motor output had contextual value. Third, the negatively modulated population spiked more when rats updated behavior following an error compared to trials without integration of error information. Finally, insufficient spiking in the positively modulated population predicted erroneous behavior under dynamic “No-go” conditions. Thus, mPFC neuronal populations with opposite spike modulation characteristics differentially encode context and behavioral updating and enable flexible integration of error corrections in future actions.

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“…Grasps varied in terms of different patterns of digit contact with the pasta (Fig. 9 ) but had two functions, to support the pasta and direct it into the mouth and to guide or hold the pasta in the mouth 22 . Guide grasps .…”

Section: Methodsmentioning

confidence: 99%

The syntactic organization of pasta-eating and the structure of reach movements in the head-fixed mouse

Whishaw

Faraji

Kuntz

et al. 2017

Sci Rep

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Mice are adept in the use of their hands for activities such as feeding, which has led to their use in investigations of the neural basis of skilled-movements. We describe the syntactic organization of pasta-eating and the structure of hand movements used for pasta manipulation by the head-fixed mouse. An ethogram of mice consuming pieces of spaghetti reveals that they eat in bite/chew bouts. A bout begins with pasta lifted to the mouth and then manipulated with hand movements into a preferred orientation for biting. Manipulation involves many hand release-reach movements, each with a similar structure. A hand is advanced from a digit closed and flexed (collect) position to a digit extended and open position (overgrasp) and then to a digit closed and flexed (grasp) position. Reach distance, hand shaping, and grasp patterns featuring precision grasps or whole hand grasps are related. To bite, mice display hand preference and asymmetric grasps; one hand (guide grasp) directs food into the mouth and the other stabilizes the pasta for biting. When chewing after biting, the hands hold the pasta in a symmetric resting position. Pasta-eating is organized and features structured hand movements and so lends itself to the neural investigation of skilled-movements.

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Parallel pathways from whisker and visual sensory cortices to distinct frontal regions of mouse neocortex

Cited by 23 publications

References 55 publications

Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task

Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task

Neural Representation of Motor Output, Context and Behavioral Adaptation in Rat Medial Prefrontal Cortex During Learned Behavior

The syntactic organization of pasta-eating and the structure of reach movements in the head-fixed mouse

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