Parallel pathways and convergence onto HVc and adjacent neostriatum of adult zebra finches (<i>Taeniopygia guttata</i>)

Fortune, Eric S.; Margoliash, Daniel

doi:10.1002/cne.903600305

Cited by 220 publications

(199 citation statements)

References 54 publications

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“…This is exactly what was found with the discovery of the connectivity of CMM and NCM to other auditory regions and the IEG response of these regions to song playback [13,53,54]. As noted in §2b, above, there is growing evidence that these regions are critical for song perception in many species, and may also function as the neural basis of song memories.…”

Section: Review Levels Of Analysis S a Macdougall-shackleton 2079supporting

confidence: 68%

The levels of analysis revisited

MacDougall‐Shackleton

2011

Phil. Trans. R. Soc. B

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The term levels of analysis has been used in several ways: to distinguish between ultimate and proximate levels, to categorize different kinds of research questions and to differentiate levels of reductionism. Because questions regarding ultimate function and proximate mechanisms are logically distinct, I suggest that distinguishing between these two levels is the best use of the term. Integrating across levels in research has potential risks, but many benefits. Consideration at one level can help generate novel hypotheses at the other, define categories of behaviour and set criteria that must be addressed. Taking an adaptationist stance thus strengthens research on proximate mechanisms. Similarly, it is critical for researchers studying adaptation and function to have detailed knowledge of proximate mechanisms that may constrain or modulate evolutionary processes. Despite the benefits of integrating across ultimate and proximate levels, failure to clearly identify levels of analysis, and whether or not hypotheses are exclusive alternatives, can create false debates. Such non-alternative hypotheses may occur between or within levels, and are not limited to integrative approaches. In this review, I survey different uses of the term levels of analysis and the benefits of integration, and highlight examples of false debate within and between levels. The best integrative biology reciprocally uses ultimate and proximate hypotheses to generate a more complete understanding of behaviour.

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Section: Review Levels Of Analysis S a Macdougall-shackleton 2079supporting

confidence: 68%

The levels of analysis revisited

MacDougall‐Shackleton

2011

Phil. Trans. R. Soc. B

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“…Units in NCM may project to HVC (Fortune and Margoliash, 1995;Vates et al, 1996), and our latency data here allow the possibility that NCM provides a major excitatory input to HVC. Some neurons in HVC show highly specific electrophysiological responses to song, but how this specificity emerges is not known.…”

Section: Function Of Ncm In Song Perception and Memorymentioning

confidence: 75%

Response Modulation in the Zebra Finch Neostriatum: Relationship to Nuclear Gene Regulation

1997

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The sound of birdsong activates robust gene expression in the caudomedial neostriatum (NCM) of songbirds. To assess the function of this genomic response, we analyzed the temporal and quantitative relationships between electrophysiological activity and gene induction. Single units in zebra finch NCM showed large increases in firing in response to birdsong, whereas simple auditory tones tended to inhibit firing. Most cells showed little selectivity for individual songs based on total number of spikes produced. When a novel song stimulus was repeated, the cells rapidly modulated their firing rates so that the first response to a stimulus was markedly higher than consecutive responses. Even after many repetitions of a particular song, cells continued to fire in response to that stimulus, unlike the complete "habituation" observed previously for genomic activity. The initial modulation of the response to a particular song disappeared, however, once that song was repeated for 200 trials (ϳ34 min). These results indicate a dissociation between gross physiological activity and "immediate early" gene expression: genomic activity occurs only during a subset of electrophysiological responses. We propose a model in which nuclear responses in NCM are modulated by pathways distinct from the primary auditory inputs to NCM. This would account for the changing selectivity of the genomic response and implies an active role for the cell nucleus as an integrating agent in the physiological operation of neural circuits.

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“…HVC receives projections from auditory areas and is implicated both in syllable sequencing and in the control of tempo (Nottebohm et al, 1976;McCasland and Konishi, 1981;Margoliash, 1983;McCasland, 1987;Vu et al, 1994;Fortune and Margoliash, 1995;Yu and Margoliash, 1996;Schmidt and Konishi, 1998; Dave and Margoliash, 2000; Figure 7. Models for feedback contributions to vocal control.…”

Section: Discussionmentioning

confidence: 99%

Real-Time Contributions of Auditory Feedback to Avian Vocal Motor Control

Sakata¹,

Brainard²

2006

J. Neurosci.

112

167

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Songbirds and humans both rely critically on hearing for learning and maintaining accurate vocalizations. Evidence strongly indicates that auditory feedback contributes in real time to human speech, but similar contributions of feedback to birdsong remain unclear. Here, we assessed real-time influences of auditory feedback on Bengalese finch song using a computerized system to detect targeted syllables as they were being sung and to disrupt feedback transiently at short and precisely controlled latencies. Altered feedback elicited changes within tens of milliseconds to both syllable sequencing and timing in ongoing song. These vocal disruptions were larger when feedback was altered at segments of song with variable sequence transitions than at stereotyped sequences. As in humans, these effects depended on the feedback delay relative to ongoing song, with the most disruptive delays approximating the average syllable duration. These results extend the parallels between speech and birdsong with respect to a moment-by-moment reliance on auditory feedback. Moreover, they demonstrate that song premotor circuitry is sensitive to auditory feedback during singing and suggest that feedback may contribute in real time to the control and calibration of song.

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Parallel pathways and convergence onto HVc and adjacent neostriatum of adult zebra finches (Taeniopygia guttata)

Cited by 220 publications

References 54 publications

The levels of analysis revisited

The levels of analysis revisited

Response Modulation in the Zebra Finch Neostriatum: Relationship to Nuclear Gene Regulation

Real-Time Contributions of Auditory Feedback to Avian Vocal Motor Control

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