1986
DOI: 10.1073/pnas.83.24.9284
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Parallel packing of alpha-helices in crystals of the zervamicin IIA analog Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Pro-OMe.2H2O.

Abstract: An apolar synthetic analog of the first 10 residues at the NH2-terminal end of zervamicin HA crystallizes in the triclinic space group P1 with cell dimensions a = 10. Ac-Trp-Ile-Gln-Aib-Ile-Thr-Aib-Leu-Aib-Hyp- 15-Gln-Aib-Hyp-Aib-Pro-Phe-ol.(Hyp is 4-hydroxyproline; Phe-ol is phenylalaninol.) The decapeptide whose structure is reported in this paper is the apolar analog of the first 10 residues in which Gln-3, Thr-6, and Hyp-10 have been replaced with Ala, Val, and Pro, respectively; the NH2 terminus has been … Show more

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Cited by 70 publications
(23 citation statements)
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“…The largest difference between the backbones in B and C occurs with a greater helix distortion in B than C helix at the penultimate residue where 4 = -150" and -96", respectively. In helices ending with an Aib residue, there often are helix distortions or reversals at the penultimate residue (see, for example, Karle et al, 1986Karle et al, , 1990a, and these appear to be independent of helix length. If residues 9 and 10 are omitted, the average values for 4 and $ in B, -60.2' and -26.7", respectively, are quite similar to those in C.…”
Section: Resultsmentioning
confidence: 99%
“…The largest difference between the backbones in B and C occurs with a greater helix distortion in B than C helix at the penultimate residue where 4 = -150" and -96", respectively. In helices ending with an Aib residue, there often are helix distortions or reversals at the penultimate residue (see, for example, Karle et al, 1986Karle et al, , 1990a, and these appear to be independent of helix length. If residues 9 and 10 are omitted, the average values for 4 and $ in B, -60.2' and -26.7", respectively, are quite similar to those in C.…”
Section: Resultsmentioning
confidence: 99%
“…The expectation was that Boc-(Aib-Ala-Leu)3-Aib-OMe would form an a-helix, or perhaps a mixed 310-helix/a-helix, like other apolar deca-and undecapeptides that contain several Aib residues (5,12). The fortuitous insertion of a water molecule into the helix of the present peptide gives rise to a stable, static model of solvation of a helix backbone.…”
Section: Discussionmentioning
confidence: 96%
“…The bulky side groups of Leu3 and Leu6, as well as the tert-butyl moiety of the Boc blocking group, are directed toward one side of the helix. On the other side, where the water molecule W(1) resides, there are only the Aib and Ala residues and, due to the bend in the helix axis, the CH3 groups of these residues are directed away from the area of W (1) There is a reversal in the sign of the value for Aib'0, which is not unusual for a terminal Aib residue (4,5).…”
Section: Tca(10)-c'(10)-o(ome) § O(obulhc(oy0(0) ¶N(1)-c(o)-o(o)mentioning
confidence: 99%
See 1 more Smart Citation
“…The crystal structure of the decapeptide fragment composed of residues 1-10 has been published (3). A helical conformation (for residues 9-16) containing three p-bend reversals (for Prol'-Ala", Aib12-Prol3, and Aib14- ribbon was proposed for the conformation of Z-(Aib-Pro)4-OMe (Z, benzyloxycarbonyl) in solution (4,5).…”
mentioning
confidence: 99%