Parallel NMR spectroscopy with simultaneous detection of ¹H and ¹⁹F nuclei

Abstract

Recording NMR signals of several nuclear species simultaneously by using parallel receivers provides more information from a single measurement and at the same time increases the measurement sensitivity per unit time. Here we present a comprehensive series of the most frequently used NMR experiments modified for simultaneous direct detection of two of the most sensitive NMR nuclei - (1) H and (19) F. We hope that the presented material will stimulate interest in and further development of this technique.

Aromatic 19F-13C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics

“…The unique chemical shift of the fluorinated 13 C resonances at ~150 ppm, separated from the aromatic 13 C H resonances (at ~120 ppm), will further aid the assignment of 19 F resonances. With the appropriate NMR probe design, experiments that encode both 1 H- 13 C and 19 F- 13 C correlations can be recorded using parallel receivers 40 .…”

Nuclear-spin-pattern control of electron-spin dynamics in a series of V(iv) complexes

“…A system patterned with 19 F nuclei is in contrast particularly advantageous since 19 F NMR is readily performed. [78][79][80] It is in these directions that we are now working.…”

Triplet NOAH supersequences optimised for small molecule structure characterisation

“…The NOAH approach represents one category of techniques that employ multi‐FID acquisitions in a single concatenated experiment that are gaining recognition as time‐efficient data collection strategies . These are attractive as they can be executed using conventional spectrometer hardware without the need for multiple receivers, as used in parallel acquisition NMR spectroscopy, nor do they suffer the technical complexities associated with single‐scan ultrafast correlation methods …”

“…The NOAH approach represents one category of techniques that employ multi-FID acquisitions in a single concatenated experiment that are gaining recognition as time-efficient data collection strategies. [3][4][5][6] These are attractive as they can be executed using conventional spectrometer hardware without the need for multiple receivers, as used in parallel acquisition NMR spectroscopy, [7][8][9] nor do they suffer the technical complexities associated with single-scan ultrafast correlation methods. [10][11][12] Recently, we have demonstrated the NOAH BS-element as being the optimum ordering to sample HMBC (B) and HSQC (S) correlation data in a single experiment and exemplified its use in the BSC and BSCN combinations (where C signifies COSY and N NOESY).…”