Parallel Early Development of Zebrafish Interrenal Glands and Pronephros: Differential Control by wt1 and ff1b

Hsu, Hwei-Jan; Lin, Guang; Chung, Bon-Chu

doi:10.1081/erc-200044044

Cited by 30 publications

(59 citation statements)

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“…In zebrafish, steroids are synthesized mainly from interrenal glands, which are a counterpart of the mammalian adrenal gland. At 24 hpf, P450ssc expression is detected when embryonic interrenal primordia start to develop, and the expression in the interrenal glands is detected all the way to adulthood (51). In this study, we observed that tspo has another expression profile.…”

Section: Tspo and Synthesis Of Steroidsmentioning

confidence: 64%

Translocator protein (18 kDa) is involved in primitive erythropoiesis in zebrafish

et al. 2009

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The translocator protein (18 kDa) (TSPO), also known as peripheral-type benzodiazepine receptor, is directly or indirectly associated with many biological processes. Although extensively characterized, the specific function of TSPO during development remains unclear. It has been reported that TSPO is involved in a variety of mechanisms, including cell proliferation, apoptosis, regulation of mitochondrial functions, cholesterol transport and steroidogenesis, and porphyrin transport and heme synthesis. Although the literature has reported a murine knockout model, the experiment did not generate information because of early lethality. We then used the zebrafish model to address the function of tspo during development. Information about spatiotemporal expression showed that tspo has a maternal and a zygotic contribution which, during somatogenesis, seems to be erythroid restricted to the intermediate cell mass. Genetic and pharmacological approaches used to invalidate Tspo function resulted in embryos with specific erythropoietic cell depletion. Although unexpected, this lack of blood cells is independent of the Tspo cholesterol binding site and reveals a new in vivo key role for Tspo during erythropoiesis.

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Section: Tspo and Synthesis Of Steroidsmentioning

confidence: 64%

Translocator protein (18 kDa) is involved in primitive erythropoiesis in zebrafish

et al. 2009

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“…First studies have demonstrated that early development of zebrafish interrenal glands resembles adrenal development in higher vertebrates (17)(18)(19). It has been demonstrated that ff1b, the zebrafish homolog of SF1, is required for interrenal differentiation and activation of side chain cleavage enzyme cyp11a1 (17,18,20). Accordingly, knockdown of ff1b activity by antisense morpholino technique led to down-regulation of interrenal steroidogenic enzymes and loss of interrenal tissue (17,18), similar to the phenotype in Sf-1 knockout mice (21).…”

mentioning

confidence: 75%

“…In teleosts the steroidogenic cells, together with closely intermingled chromaffin cells, are embedded in the head kidney forming the interrenal organ, the homolog to the mammalian adrenal gland (15,16). First studies have demonstrated that early development of zebrafish interrenal glands resembles adrenal development in higher vertebrates (17)(18)(19). It has been demonstrated that ff1b, the zebrafish homolog of SF1, is required for interrenal differentiation and activation of side chain cleavage enzyme cyp11a1 (17,18,20).…”

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confidence: 99%

Pituitary-Interrenal Interaction in Zebrafish Interrenal Organ Development

Hahner

Nica

et al. 2007

Molecular Endocrinology

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To further elucidate pituitary adrenal interactions during development, we studied the organogenesis of the interrenal organ, the teleost homolog of the mammalian adrenal gland, in zebrafish. To this end we compared wild-type zebrafish interrenal development with that of mutants lacking pituitary cell types including corticotrophs. In addition, we studied the effects of ACTH receptor (Mc2r) knockdown and dexamethasone (dex) on interrenal development and pituitary feedback. Until 2 d post fertilization (2 dpf) interrenal development assessed by transcripts of key steroidogenic genes (cyp11a1, mc2r, star) is independent of proopiomelanocortin (Pomc) as demonstrated in aal/eya1and lia/fgf3 mutants. However, at 5 dpf lack of pituitary cells leads to reduced expression of steroidogenic genes at both the transcriptional and the protein level. Pituitary control of interrenal development resides in corticotrophs, because pit1 mutants lacking pituitary cells except corticotrophs have a phenotype similar to that of wild-type controls. Furthermore, development in mc2r knockdown morphants does not differ from aal/eya1 and lia/fgf3 mutants. Inhibition of steroidogenesis by mc2r knockdown induces up-regulation of pomc expression in the anterior domain of pituitary corticotrophs. Accordingly, dex suppresses pomc in the anterior domain only, leading to impaired expression of steroidogenic genes commencing at 3 dpf and interrenal hypoplasia via reduced interrenal proliferation. In contrast, negative feedback on pituitary corticotrophs by dex is evident at 2 dpf and precedes effects of Pomc on the interrenal primordium. These data demonstrate a gradual transition from early pituitary-independent interrenal organogenesis to developmental control by the anterior domain of pituitary corticotrophs acting via Mc2 receptors.

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“…No detailed ultrastructural studies were performed on the aminergic or steroidogenic components, but Fishelson, in a work on the ontogenesis and functional metamorphosis of the head kidney of some Teleostei Cichlidae, gave some outlines on interrenal and chromaffin cells (Fishelson 1996). More recently, some studies were performed in zebra fish on the differentiation and maturation of dorsal root and sympathetic ganglion neurons and chromaffin cells and on the regulation of development of the interrenal organ (Chai et al 2003, Hsu et al 2003.…”

Section: Introductionmentioning

confidence: 98%

The development of adrenal homolog of rainbow trout Oncorhynchus mykiss: an immunohistochemical and ultrastructural study

Gallo

Civinini

2004

Anat Embryol

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In this work we describe the adrenal homolog of the rainbow trout Oncorhynchus mykiss during development. At the histological level, the interrenal primordium is clearly evident in larvae 25 days after fertilization (dpf), and the immunohistochemical reactions for tyrosine hydroxylase (TH) and phenylethanolamine-N-methyltransferase (PNMT), which mark the chromaffin cells, appear as early as 27 dpf. Both reactions are evident in cells localized in the head kidney and in some, probably migrating, cells close to the notochord. In 27-dpf larvae, the ultrastructural analysis shows the presence of the interrenal cells with mitochondria with tubulovesicular cristae, typical of steroidogenic cells, sometimes surrounded by smooth endoplasmic reticulum (SER) cisternae, indicating that in this stage the cells have the capacity for steroid synthesis and secretion. In the same stage the chromaffin cells are characterized by few and small membrane-bound granules containing cores of heterogeneous electron density. Both types of cells show large nuclei, numerous free or clumped ribosomes, developed rough endoplasmic reticulum (RER), and scarce SER. Rare nerve endings contacting chromaffin cells are present. In the subsequent developmental stages, a further differentiation of both types of cells is evidenced by modifications of cell organelles as mitochondria, chromaffin granules, RER, SER, and so on. A clear discrimination of the two types of catecholamine-containing cells, adrenaline and noradrenaline cells, is evident only 5 days after hatching. The presence of different interrenal cell types in larvae at 5 and 10 days after hatching probably indicates the activation of a physiological cellular cycle. The immunohistochemical and ultrastructural results are compared with those obtained by other authors in the same and other vertebrate species.

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Parallel Early Development of Zebrafish Interrenal Glands and Pronephros: Differential Control by wt1 and ff1b

Cited by 30 publications

References 0 publications

Translocator protein (18 kDa) is involved in primitive erythropoiesis in zebrafish

Translocator protein (18 kDa) is involved in primitive erythropoiesis in zebrafish

Pituitary-Interrenal Interaction in Zebrafish Interrenal Organ Development

The development of adrenal homolog of rainbow trout Oncorhynchus mykiss: an immunohistochemical and ultrastructural study

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