Parallel Assessment of Chemotherapy Adherence and Supportive Therapy Adherence on Occurrence and Minimization of Adverse Drug Reactions Among Cancer Patients: A Clinical-Based Observational Study

Kumar, Jitendra; Gudhoor, Manjula; Ganachari, M. S.

doi:10.1177/8755122520901739

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…As a result, men were found to be less adherent than women. This finding is consistent with a study conducted in India 33 in which men had a nearly threefold increase in the risk of non-adherence when compared to women. This is due to the fact that men are burdened by outdoor activities that keep them busy and cause them to forget their medications.…”

Section: Discussionsupporting

confidence: 92%

Adherence to Chemotherapy and Associated Factors Among Patients With Cancer in Amhara Region, Northeastern Ethiopia, 2022. A Cross-Sectional Study

Bekalu,

Wudu,

Gashu

2023

Cancer Control

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Background Cancer is the leading cause of death worldwide, and poor adherence to chemotherapy has become a public health issue in developing countries, including Ethiopia. Objective To assess chemotherapy adherence and associated factors among patients with cancer in the Amhara Region, Northeast Ethiopia. Methods A hospital-based prospective cross-sectional study design was employed, and a total of 460 cancer patients were enrolled using a systematic random sampling method at Felege Hiwot and Dessie comprehensive specialized hospitals from May 15, 2022, to July 15, 2022, in the Amhara region. The data was gathered through a review of medical records and a face-to-face interview and entered into Epi-Data version 4.6 before being exported to SPSS version 26 for analysis. Furthermore, at 95% confident interval (CI), multivariable binary logistic regression was used, and variables with P-values of <.05 were found to be significant. Result The overall response rate in this study was 94.1% (433), with 42.3% of patients adhering to chemotherapy. Moreover, having a family history of cancer [AOR = 3.58, 95% CI (2.22, 5.76)], being female [Adjusted Odds ratio (AOR) = 2.17, 95% CI: (1.31, 3.60)], having no history of comorbidity [AOR = 2.74, 95% CI (1.56, 4.81)], having side effects from chemotherapy [AOR = 3.50, 95% CI (1.55, 7.90)], and having social support [AOR = 1.52, 95% CI (1.21, 1.95)] were important predictors of chemotherapy adherence. Conclusion and recommendations: Patients' understanding of illness characteristics and treatment should be improved through health education. Involving family members in the treatment plan will also improve adherence to chemotherapy in this context.

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Section: Discussionsupporting

confidence: 92%

Adherence to Chemotherapy and Associated Factors Among Patients With Cancer in Amhara Region, Northeastern Ethiopia, 2022. A Cross-Sectional Study

Bekalu,

Wudu,

Gashu

2023

Cancer Control

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“…Compared with women, men had lower adherence. This nding is in line with a study performed in India (30). This might be because most of the time, females are more strict and may obey the direction of a health care worker's advice for medication adherence.…”

Section: Discussionsupporting

confidence: 90%

“…This study showed that the proportion of cancer patients in the Amhara region of Northeast Ethiopia who were receiving chemotherapy was 42.3% (95% CI, 37.6-46.7). The proportion of patients receiving chemotherapy in this study was greater than that in studies conducted in Nigeria (19.1%) (29) and India (21.1%) (30).…”

Section: Discussioncontrasting

confidence: 79%

Adherence to Chemotherapy and Associated Factors among Patients with Cancer in the Amhara Region, Northeast Ethiopia, 2022.

Ademe,

Mohammed,

Edmealem

et al. 2024

Preprint

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Background: Chemotherapy compliance is a joint effort and silent understanding between health workers and clients. Inadequate drug compliance is concerning due to the decreased treatment outcome of the drug. This will lead to poor survival, increased relapse, treatment failure, and elevated healthcare costs. A measure of patient treatment adherence is important for attracting the attention of healthcare providers to achieve optimal outcomes such as curative treatment or quality of life improvement. Objective: To assess the adherence to chemical treatment and associated factors among cancer patients in the Amhara Region, Northeast Ethiopia, in 2022. Methods and Materials: A retrospective cohort study was conducted with 460 cancer patients in the Amhara region using systematic randomized sampling from May 28, 2022, to June 22, 2022. An interview-based, previously tested questionnaire was used for data collection. The data have been entered into Epi-Data version 4.6 and subsequently exported to Statistical Package for Social Science version 26 for analysis. A bivariable logistic regression was carried out, and variables with a p value of 0.25 were analyzed to select the candidate variable for multivariable logistic regression. A multivariable logistic regression was carried out, and variables with a p value less than 0.05 were considered important factors and are presented as the AOR and 95% CI. The suitability of the model was verified with the Hosmer Lemeshow test, and multicollinearity was verified with a standard error. Results: Of the total respondents, 94.1% (433) of the cancer patients were involved, and the proportion of patients who adhered to chemotherapy was 42.3%. Having a family history of cancer [AOR = 3.58, 95% CI (2.22, 5.76)], being a woman [AOR = 2.17, 95% CI: (1.31, 3.60)], not having a history of comorbidity [AOR = 2.74, 95% CI (1.56, 4.81)], having no serious side effects from chemotherapy[AOR = 3.50, 95% CI (1.55, 7.90)], or social support [AOR = 1.52, 95% CI (1.21, 1.95)] were associated factors with chemotherapy adherence. Conclusion and recommendations: Health workers should contribute to the development of social support and mechanisms to reduce the occurrence of side effects of chemotherapy medication among cancer patients who have comorbidities.

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“…Cancer is a global disease which is certainly managed and treated using cytotoxic drugs (CDs). 1 The CDs are toxic in nature. International Agency for Research on Cancer (IARC) have classified some of the anti-cancer agents as human carcinogens.…”

Section: Introductionmentioning

confidence: 99%

Onco-pharmacist led evaluation of knowledge, attitude & practice (KAP) of safe handling cytotoxic drugs among health care professional's (HCP's) in tertiary care hospital: A hospital based interventional Study

Gudhoor

Ganachari

Kumar

et al. 2021

J Oncol Pharm Pract

Self Cite

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Background Cytotoxic drugs (CDs) are hazardous in nature. But it is necessary for the treatment in cancer patients. The healthcare professionals (HCPs) act as a facilitator through which the manufactured CDs reach the patient. However, safe handling of CDs becomes a primary concern not only for the recipients but also for the HCPs. Methods On Ethics committee approval, a prospective- interventional study was conducted among HCPs who are involved in handling of CDs in Oncology department of tertiary care hospital. The participants were screened for their eligibility criteria & 73 HCPs were recruited. The initial data was collected from the HCPs through interview & questionnaires. Later the participants were trained by oncology-pharmacist (7–8 months) for safe handling of CDs. After the training the participants were tested again through interview & questionnaires. Results 73 participants, (75%) nurses & (25%) physicians were included in the study. Among these participants, only 32.87% underwent training on reconstitution whereas 67.12% of the participants didn't undergo any training. The increase in mean score of KAP after the training was observed to be 3.44 ± 4.32, 1.23 ± 1.51 and 1.3 ± 1.01 respectively. Conclusion The study concludes that mandatory requirement of training for HCPs using SOP's by qualified oncology-pharmacist to minimize the hazardous effects of CDs. It also highlights the improvisation techniques for handling of CDs will enhance the safety profile of HCPs & the patients, which helps in refining the quality of pharmaceutical and health care services provided in the cancer care settings.

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Parallel Assessment of Chemotherapy Adherence and Supportive Therapy Adherence on Occurrence and Minimization of Adverse Drug Reactions Among Cancer Patients: A Clinical-Based Observational Study

Cited by 6 publications

References 10 publications

Adherence to Chemotherapy and Associated Factors Among Patients With Cancer in Amhara Region, Northeastern Ethiopia, 2022. A Cross-Sectional Study

Adherence to Chemotherapy and Associated Factors Among Patients With Cancer in Amhara Region, Northeastern Ethiopia, 2022. A Cross-Sectional Study

Adherence to Chemotherapy and Associated Factors among Patients with Cancer in the Amhara Region, Northeast Ethiopia, 2022.

Onco-pharmacist led evaluation of knowledge, attitude & practice (KAP) of safe handling cytotoxic drugs among health care professional's (HCP's) in tertiary care hospital: A hospital based interventional Study

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