2019
DOI: 10.1101/795716
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Parallel and Population-specific Gene Regulatory Evolution in Cold-Adapted Fly Populations

Abstract: 17Changes in gene regulation at multiple levels may comprise an important share of the molecular 18 changes underlying adaptive evolution in nature. However, few studies have assayed within-and 19 between-population variation in gene regulatory traits at a transcriptomic scale, and therefore 20 inferences about the characteristics of adaptive regulatory changes have been elusive. Here, we assess 21 quantitative trait differentiation in gene expression levels and alternative splicing (intron usage) 22 betwee… Show more

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Cited by 4 publications
(3 citation statements)
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References 140 publications
(169 reference statements)
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“…The genes containing these lineage‐specific isoforms were enriched in biological functions associated with phenotypic traits specific to the lotus. Herein our results show how lineage‐specific isoforms can drive phenotypic differences between closely related lineages during evolution, in line with previous findings in other closely related species (Huang et al., 2021; Thatcher et al., 2014; Zhang, Wang, et al., 2017).…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…The genes containing these lineage‐specific isoforms were enriched in biological functions associated with phenotypic traits specific to the lotus. Herein our results show how lineage‐specific isoforms can drive phenotypic differences between closely related lineages during evolution, in line with previous findings in other closely related species (Huang et al., 2021; Thatcher et al., 2014; Zhang, Wang, et al., 2017).…”
Section: Discussionsupporting
confidence: 92%
“…Previous studies showed how isoforms with species‐specific expression resulted in functional divergence between proteins of the same family and hence drove divergence of phenotypic traits between species (Huang et al., 2021; Smith et al., 2018; Smith et al., 2021; Thatcher et al., 2014; Zhang, Wang, et al., 2017). Also, when comparing isoforms between the two Nelumbo species, we identified 4854 N. nucifera genes and 4424 N. lutea genes that gave rise to lineage‐specific isoforms in each of their respective lineages.…”
Section: Discussionmentioning
confidence: 99%
“…Because the expression of genes is expected to affect phenotypic traits, and thus to condition the fitness of organisms, the gene expression pattern is believed to respond to selection, at least for a subset of genes. For instance, specific sets of genes have been shown to change consistently in the wild (Philippe et al ., 2007; Verta and Jones, 2019; Huang et al ., 2021) or during experimental evolution (Philippe et al ., 2007; Ghalambor et al ., 2015; Jallet et al ., 2020). In contrast, the structure of the network itself is less directly submitted to natural selection.…”
Section: Introductionmentioning
confidence: 99%